Cloned (Comment) | Organism |
---|---|
gene NNMT, quantitative enzyme expression anaysis in 124 nasopharyngeal carcinoma samples, analysis of associations between NNMT and pAktSer473 expression and other important clinicopathologic variables, overview | Homo sapiens |
Protein Variants | Comment | Organism |
---|---|---|
additional information | forced NNMT overexpression strongly induces the invasive capacity in human embryonic kidney 293 cells | Homo sapiens |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
gene NNMT | - |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
additional information | the enzyme is overexpressed in many human cancers and is associated with poor prognosis | Homo sapiens | - |
nasopharyngeal carcinoma cell | - |
Homo sapiens | - |
Synonyms | Comment | Organism |
---|---|---|
NNMT | - |
Homo sapiens |
Organism | Comment | Expression |
---|---|---|
Homo sapiens | the NNMT gene is differentially upregulated in nasopharyngeal cancer tissues | up |
General Information | Comment | Organism |
---|---|---|
malfunction | nicotinamide N-methyltransferase overexpression is associated with Akt phosphorylation and indicates worse prognosis in patients with nasopharyngeal carcinoma | Homo sapiens |
metabolism | NNMTexpression is significantly positively associated with pAkt/protein kinase B expression | Homo sapiens |
physiological function | the enzyme is overexpressed in many human cancers and is associated with poor prognosis. Enzyme NNMT might play a significant role in tumor progression and shorter survival time in patients with nasopharyngeal carcinoma, and it might promote the activation of MMP-2 via a pathway that sequentially involves pAkt signaling pathway | Homo sapiens |