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Literature summary for 2.1.1.1 extracted from

  • Hong, S.; Moreno-Navarrete, J.M.; Wei, X.; Kikukawa, Y.; Tzameli, I.; Prasad, D.; Lee, Y.; Asara, J.M.; Fernandez-Real, J.M.; Maratos-Flier, E.; Pissios, P.
    Nicotinamide N-methyltransferase regulates hepatic nutrient metabolism through Sirt1 protein stabilization (2015), Nat. Med., 21, 887-894.
    View publication on PubMedView publication on EuropePMC

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
S-adenosyl-L-methionine + nicotinamide Mus musculus
-
S-adenosyl-L-homocysteine + 1-methylnicotinamide
-
?
S-adenosyl-L-methionine + nicotinamide Mus musculus C57Bl6/J
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S-adenosyl-L-homocysteine + 1-methylnicotinamide
-
?

Organism

Organism UniProt Comment Textmining
Mus musculus
-
-
-
Mus musculus C57Bl6/J
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
hepatocyte primary Mus musculus
-
liver hepatic expression of Nnmt is highly variable and correlates with multiple metabolic parameters in humans Mus musculus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
S-adenosyl-L-methionine + nicotinamide
-
Mus musculus S-adenosyl-L-homocysteine + 1-methylnicotinamide
-
?
S-adenosyl-L-methionine + nicotinamide
-
Mus musculus C57Bl6/J S-adenosyl-L-homocysteine + 1-methylnicotinamide
-
?

Synonyms

Synonyms Comment Organism
NNMT
-
Mus musculus

Cofactor

Cofactor Comment Organism Structure
S-adenosyl-L-methionine
-
Mus musculus

Expression

Organism Comment Expression
Mus musculus hepatic expression of Nnmt is highly variable and correlates with multiple metabolic parameters in mice additional information

General Information

General Information Comment Organism
malfunction suppression of hepatic Nnmt expression in vivo alters glucose and cholesterol metabolism. Primary hepatocytes with Nnmt knockdown have signifi­cantly lower hepatocyte glucose output (50%) and significantly lower expression of genes encoding both catalytic glucose-6-phosphatase (20%) and cytosolic phosphoenolpyruvate carboxykinase 1 (40%) compared with control hepatocytes. In contrast, primary hepatocytes in which Nnmt is overexpressed have 1.4fold higher glucose output, threefold higher expression of glucose-6-phosphatase and fourfold higher expression of phosphoenolpyruvate carboxykinase compared with control hepatocytes Mus musculus
metabolism enzyme Nnmt regulates glucose and cholesterol metabolism. Sirt1 is required for the metabolic actions of the enzyme, which regulates Sirt1 stability Mus musculus
physiological function nicotinamide N-methyltransferase is a metabolic regulator in adipocytes and also regulates hepatic nutrient metabolism through Sirt1 protein stabilization, the metabolic effects of the enzyme in the liver are mediated by its product 1-methylnicotinamide. Nnmt is a positive regulator of gluconeogenesis in primary hepatocytes. Methylation of nicotinamide by Nnmt is a major pathway for the clear­ance of excess vitamin B3 from the body Mus musculus