Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
S-adenosyl-L-methionine + nicotinamide | Mus musculus | - |
S-adenosyl-L-homocysteine + 1-methylnicotinamide | - |
? | |
S-adenosyl-L-methionine + nicotinamide | Mus musculus C57Bl6/J | - |
S-adenosyl-L-homocysteine + 1-methylnicotinamide | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Mus musculus | - |
- |
- |
Mus musculus C57Bl6/J | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
hepatocyte | primary | Mus musculus | - |
liver | hepatic expression of Nnmt is highly variable and correlates with multiple metabolic parameters in humans | Mus musculus | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
S-adenosyl-L-methionine + nicotinamide | - |
Mus musculus | S-adenosyl-L-homocysteine + 1-methylnicotinamide | - |
? | |
S-adenosyl-L-methionine + nicotinamide | - |
Mus musculus C57Bl6/J | S-adenosyl-L-homocysteine + 1-methylnicotinamide | - |
? |
Synonyms | Comment | Organism |
---|---|---|
NNMT | - |
Mus musculus |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
S-adenosyl-L-methionine | - |
Mus musculus |
Organism | Comment | Expression |
---|---|---|
Mus musculus | hepatic expression of Nnmt is highly variable and correlates with multiple metabolic parameters in mice | additional information |
General Information | Comment | Organism |
---|---|---|
malfunction | suppression of hepatic Nnmt expression in vivo alters glucose and cholesterol metabolism. Primary hepatocytes with Nnmt knockdown have significantly lower hepatocyte glucose output (50%) and significantly lower expression of genes encoding both catalytic glucose-6-phosphatase (20%) and cytosolic phosphoenolpyruvate carboxykinase 1 (40%) compared with control hepatocytes. In contrast, primary hepatocytes in which Nnmt is overexpressed have 1.4fold higher glucose output, threefold higher expression of glucose-6-phosphatase and fourfold higher expression of phosphoenolpyruvate carboxykinase compared with control hepatocytes | Mus musculus |
metabolism | enzyme Nnmt regulates glucose and cholesterol metabolism. Sirt1 is required for the metabolic actions of the enzyme, which regulates Sirt1 stability | Mus musculus |
physiological function | nicotinamide N-methyltransferase is a metabolic regulator in adipocytes and also regulates hepatic nutrient metabolism through Sirt1 protein stabilization, the metabolic effects of the enzyme in the liver are mediated by its product 1-methylnicotinamide. Nnmt is a positive regulator of gluconeogenesis in primary hepatocytes. Methylation of nicotinamide by Nnmt is a major pathway for the clearance of excess vitamin B3 from the body | Mus musculus |