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Literature summary for 2.1.1.1 extracted from

  • Liu, K.Y.; Mistry, R.J.; Aguirre, C.A.; Fasouli, E.S.; Thomas, M.G.; Klamt, F.; Ramsden, D.B.; Parsons, R.B.
    Nicotinamide N-methyltransferase increases complex I activity in SH-SY5Y cells via sirtuin 3 (2015), Biochem. Biophys. Res. Commun., 467, 491-496.
    View publication on PubMed

Cloned(Commentary)

Cloned (Comment) Organism
recombinant stable expression of NNMT-V5 in SH-SY5Y cells increases complex I activity via sirtuin 3 Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
S-adenosyl-L-methionine + nicotinamide Homo sapiens
-
S-adenosyl-L-homocysteine + 1-methylnicotinamide
-
?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
brain the enzyme is significantly overexpressed in a variety of diseases ranging from cancer to hepatic cirrhosis Homo sapiens
-
additional information SH-SY5Y human neuroblastoma cells have no endogenous expression of enzyme NNMT Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
S-adenosyl-L-methionine + nicotinamide
-
Homo sapiens S-adenosyl-L-homocysteine + 1-methylnicotinamide
-
?

Synonyms

Synonyms Comment Organism
NNMT
-
Homo sapiens

Cofactor

Cofactor Comment Organism Structure
S-adenosyl-L-methionine
-
Homo sapiens

General Information

General Information Comment Organism
additional information in vitro overexpression of the enzyme has revealed many cytoprotective effects of NNMT, in particular increased complex I activity and ATP synthesis. siRNA-mediated silencing of sirtuin 3 expression decreases complex I activity in NNMT-expressing SH-SY5Y cells to that observed in wild-type SH-SY5Y, and significantly reduces cellular ATP content also Homo sapiens
physiological function expression of enzyme NNMT in enzyme-deficient SH-SY5Y human neuroblastoma cells significantly increases the expression of all three sirtuins, class III DNA deacetylase enzymes known to regulate mitochondrial energy production and cell cycle. Sirtuin 3 is a key mediator of NNMT-induced complex I activity and ATP synthesis. Central role for enzyme NNMT in the regulation of energy homeostasis Homo sapiens