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Literature summary for 1.9.6.1 extracted from

  • Lopez, C.A.; Rivera-Chavez, F.; Byndloss, M.X.; Baeumler, A.J.
    The periplasmic nitrate reductase NapABC supports luminal growth of Salmonella enterica serovar typhimurium during colitis (2015), Infect. Immun., 83, 3470-3478 .
    View publication on PubMedView publication on EuropePMC

Cloned(Commentary)

Cloned (Comment) Organism
cloning of napABC, quantitative PCR-based expression analysis Salmonella enterica

Protein Variants

Protein Variants Comment Organism
additional information constructin of a napA mutant strain CAL277, and of several other nap gene mutants, overview Salmonella enterica

Localization

Localization Comment Organism GeneOntology No. Textmining
periplasm
-
Salmonella enterica
-
-

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2 ferrocytochrome + 2 H+ + nitrate Salmonella enterica
-
2 ferricytochrome + nitrite
-
r
2 ferrocytochrome + 2 H+ + nitrate Salmonella enterica SL1344 AND CAL128
-
2 ferricytochrome + nitrite
-
r

Organism

Organism UniProt Comment Textmining
Salmonella enterica
-
serovar typhimurium
-
Salmonella enterica SL1344 AND CAL128
-
serovar typhimurium
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2 ferrocytochrome + 2 H+ + nitrate
-
Salmonella enterica 2 ferricytochrome + nitrite
-
r
2 ferrocytochrome + 2 H+ + nitrate
-
Salmonella enterica SL1344 AND CAL128 2 ferricytochrome + nitrite
-
r

Synonyms

Synonyms Comment Organism
NapABC
-
Salmonella enterica
periplasmic nitrate reductase
-
Salmonella enterica

Cofactor

Cofactor Comment Organism Structure
cytochrome c
-
Salmonella enterica

General Information

General Information Comment Organism
malfunction Salmonella enterica serovar Typhimurium strains with defects in either nitrate reductase A (narG mutant) or the regulator inducing its transcription in the presence of high concentrations of nitrate (narL mutant) exhibit growth comparable to that of wild-type Salmonella enterica serovar Typhimurium. In contrast, a strain lacking a functional periplasmic nitrate reductase (napA mutant) exhibits a marked growth defect in the lumen of the colon. Inactivation of narP, encoding a response regulator that activates napABC transcription in response to low nitrate concentrations, significantly reduces the growth of Salmonella enterica serovar Typhimurium in the murine host gut lumen Salmonella enterica
additional information the Salmonella enterica serovar Typhimurium genome contains three nitrate reductases, encoded by the narGHI, narZYV, and napABC genes Salmonella enterica
physiological function Salmonella enterica serovar Typhimurium uses the periplasmic nitrate reductase to support its growth on the low nitrate concentrations encountered in the gut, a strategy that may be shared with other enteric pathogens Salmonella enterica