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Literature summary for 1.8.98.2 extracted from
- Molecular mechanism of the reduction of cysteine sulfinic acid of peroxiredoxin to cysteine by mammalian sulfiredoxin (2006), J. Biol. Chem., 281, 14400-14407.
Activating Compound
| Activating Compound | Comment | Organism | Structure |
|---|---|---|---|
| ATP | - |
Homo sapiens |  |
Protein Variants
| Protein Variants | Comment | Organism |
|---|---|---|
| C99A | Cys99 replaced by Ala | Homo sapiens |
| C99S | Cys99 replaced by Ser | Homo sapiens |
| D57N | Asp57 replaced by Asn | Homo sapiens |
| D79N | Asp60 replaced by Asn | Homo sapiens |
| H99N | His99 replaced by Asn | Homo sapiens |
| K60R | Lys60 replaced by Arg | Homo sapiens |
| R100M | Arg100 replaced by Met | Homo sapiens |
| R50M | Arg50 replaced by Met | Homo sapiens |
Metals/Ions
| Metals/Ions | Comment | Organism | Structure |
|---|---|---|---|
| Mg2+ | - |
Homo sapiens | |
Molecular Weight [Da]
| Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
|---|---|---|---|
| 12000 | - |
SDS-PAGE | Homo sapiens |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Homo sapiens | - |
- |
- |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| peroxiredoxin-(S-hydroxy-S-oxocysteine) + ATP + 2 R-SH | - |
Homo sapiens | peroxiredoxin-(S-hydroxycysteine) + ADP + phosphate + R-S-S-R | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| Srx | - |
Homo sapiens |
Turnover Number [1/s]
| Turnover Number Minimum [1/s] | Turnover Number Maximum [1/s] | Substrate | Comment | Organism | Structure |
|---|---|---|---|---|---|
| 0.003 | - |
peroxiredoxin-(S-hydroxy-S-oxocysteine) | at 30°C | Homo sapiens | |
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Release 2023.1 (January 2023)
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