Cloned (Comment) | Organism |
---|---|
gene dmsA, DNA and amino acid sequence comparisons and phylogenetic analysis, detailed overview | Escherichia coli |
Metals/Ions | Comment | Organism | Structure |
---|---|---|---|
Molybdenum | required | Escherichia coli |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
dimethylsulfoxide + menaquinol | Escherichia coli | - |
dimethylsulfide + menaquinone + H2O | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Escherichia coli | P18775 | - |
- |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
dimethylsulfoxide + menaquinol | - |
Escherichia coli | dimethylsulfide + menaquinone + H2O | - |
? |
Synonyms | Comment | Organism |
---|---|---|
dimethyl sulfoxide reductase | - |
Escherichia coli |
DmsA | - |
Escherichia coli |
DMSO reductase | - |
Escherichia coli |
DMSOR | - |
Escherichia coli |
respiratory dimethyl sulfoxide reductase | - |
Escherichia coli |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
molybdenum cofactor | - |
Escherichia coli |
General Information | Comment | Organism |
---|---|---|
evolution | ubiquitous in Archaea and Bacteria, mononuclear molybdoenzymes of the dimethyl sulfoxide reductase (DMSOR) family are believed to have been core components of the first anaerobic respiratory chains, and thus present at life's origins. The family, which has been defined by the presence of a mononuclear molybdopterin or tungstopterin bis(pyranopterin guanine dinucleotide) (Mo/W-bisPGD) cofactor, is named after DMSO reductases, the first members of the family to be well-characterized. Phylogenetic analysis of DMSOR family clades and members, detailed overview. The enzyme belongs to a clade of DMSOR members that include the respiratory dimethyl sulfoxide reductase (DmsA), respiratory nitrate reductase (NarG), PsrA/PhsA/SrrA, ArxA/ArrA, and TtrA/SrdA/archaeal arsenate reductase lineages that interact with the membrane quinone pool during anaerobic respiration using the canonical subunits. The association of DMSOR members with characteristic electron transfer and membrane anchor subunits arose once early in the evolution of DSMORs and co-evolved with these representatives through multiple diversification events | Escherichia coli |