Organism | UniProt | Comment | Textmining |
---|---|---|---|
Streptococcus gordonii | - |
- |
- |
Streptococcus gordonii SecCR1 | - |
- |
- |
Synonyms | Comment | Organism |
---|---|---|
SdbA | - |
Streptococcus gordonii |
General Information | Comment | Organism |
---|---|---|
physiological function | inactivation of SdbA results in enhanced biofilm formation. Biofilm formation is mediated by the interaction between the CiaRH and ComDE two-component signalling systems. CiaRH is upregulated in the SdbA mutant and is essential for the enhanced biofilm phenotype. The enhanced biofilm phenotype also corresponds to increased oral colonization in mice | Streptococcus gordonii |
physiological function | SdbA mutants lack bacteriocin activity due to strong repression of bacteriocin gene. The Com pathway is functional but not activated in the SdbA mutant. Repression of bacteriocin production is mediated by the CiaRH two-component system, which is strongly upregulated in the sdbA mutant. The CiaRH-induced protease DegP is also upregulated in the SdbA mutant | Streptococcus gordonii |