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Literature summary for 1.8.4.2 extracted from

  • Chandler, M.L.; Varandani, P.T.
    Insulin degradation. II. The widespread distribution of glutathione-insulin transhydrogenase in the tissues of the rat (1972), Biochim. Biophys. Acta, 286, 136-145.
    View publication on PubMed

Activating Compound

Activating Compound Comment Organism Structure
phosphatidylethanolamine activates at low concentration Rattus norvegicus
phosphatidylethanolamine activates at low concentration Bos taurus

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
additional information
-
additional information
-
Bos taurus
additional information
-
additional information Km in different tissues for GSH and insulin Rattus norvegicus
0.003 0.012 Insulin enzymes from different rat tissues Rattus norvegicus
0.8 1.7 GSH enzyme from different rat tissues Rattus norvegicus

Organism

Organism UniProt Comment Textmining
Bos taurus
-
-
-
Rattus norvegicus
-
-
-

Purification (Commentary)

Purification (Comment) Organism
-
Bos taurus

Source Tissue

Source Tissue Comment Organism Textmining
adipose tissue
-
Rattus norvegicus
-
brain
-
Rattus norvegicus
-
diaphragm
-
Rattus norvegicus
-
heart
-
Rattus norvegicus
-
heart
-
Bos taurus
-
intestine
-
Rattus norvegicus
-
kidney
-
Rattus norvegicus
-
kidney
-
Bos taurus
-
liver
-
Rattus norvegicus
-
liver
-
Bos taurus
-
lung
-
Rattus norvegicus
-
additional information relative activities of enzyme in various tissues Rattus norvegicus
-
additional information relative activities of enzyme in various tissues Bos taurus
-
pancreas
-
Rattus norvegicus
-
pancreas
-
Bos taurus
-
skeletal muscle
-
Rattus norvegicus
-
spleen
-
Rattus norvegicus
-
testis
-
Rattus norvegicus
-
thymus
-
Rattus norvegicus
-

Specific Activity [micromol/min/mg]

Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
additional information
-
-
Bos taurus
additional information
-
tissue distribution Rattus norvegicus
758
-
purified enzyme Bos taurus

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
GSH + insulin
-
Bos taurus GSSG + reduced insulin chain A and B
-
?
GSH + protein disulfide
-
Rattus norvegicus GSSG + protein-dithiol
-
?
GSH + protein disulfide
-
Bos taurus GSSG + protein-dithiol
-
?

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
37
-
assay at Rattus norvegicus
37
-
assay at Bos taurus