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Literature summary for 1.8.4.14 extracted from

  • Etienne, F.; Spector, D.; Brot, N.; Weissbach, H.
    A methionine sulfoxide reductase in Escherichia coli that reduces the R enantiomer of methionine sulfoxide (2003), Biochem. Biophys. Res. Commun., 300, 378-382.
    View publication on PubMed
Search for more literature for 1.8.4.14

Organism

Organism UniProt Comment Textmining
Escherichia coli
-
-
-
Escherichia coli MC1061
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-
-

Purification (Commentary)

Purification (Comment) Organism
partial Escherichia coli
partially purified by (NH4)2SO4 precipitation (30-60% saturation) from MsrA/MsrB double mutants Escherichia coli

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
L-methionine (R)-sulfoxide + thioredoxin
-
 Escherichia coli L-methionine + thioredoxin disulfide + H2O
-
 ?
L-methionine (R)-sulfoxide + thioredoxin
-
 Escherichia coli MC1061 L-methionine + thioredoxin disulfide + H2O
-
 ?
L-methionine + thioredoxin disulfide + H2O enzyme specific for free L-methionine-(R)-sulfoxide and not met-R-(o) in peptide linkage Escherichia coli L-methionine (R)-S-oxide + thioredoxin
-
 ?
L-methionine + thioredoxin disulfide + H2O enzyme specific for free L-methionine-(R)-sulfoxide and not met-R-(o) in peptide linkage Escherichia coli MC1061 L-methionine (R)-S-oxide + thioredoxin
-
 ?

Synonyms

Synonyms Comment Organism
fRMsr
-
 Escherichia coli
methionine sulfoxide reductase
-
 Escherichia coli

Cofactor

Cofactor Comment Organism Structure
dithiothreitol DTT can replace NADPH, but is much less effective Escherichia coli
NADPH absolute requirement Escherichia coli
thioredoxin omission results in a 70% drop in activity Escherichia coli