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Literature summary for 1.8.4.12 extracted from
- Methionine sulfoxide reductases: selenoprotein forms and roles in antioxidant protein repair in mammals (2007), Biochem. J., 407, 321-329.
Localization
| Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|
| endoplasmic reticulum | MsrB3 has consecutive endoplasmic reticulum and mitochondrial targeting signals at the N-terminus. This protein is targeted to the endoplasmic reticulum, and the function of the mitochondrial signal appears to be masked by the endoplasmic reticulum signal peptide | Mus musculus | 5783 | - |
| endoplasmic reticulum | MsrB3A contains an endoplasmic reticulum signal peptide at the N-terminus and an endoplasmic reticulum retention signal at the C-terminus, and is targeted to the endoplasmic reticulum | Homo sapiens | 5783 | - |
| mitochondrion | MsrB3B contains a different signal peptide at the N-terminus and is targeted to mitochondria | Homo sapiens | 5739 | - |
Metals/Ions
| Metals/Ions | Comment | Organism | Structure |
|---|---|---|---|
| selenium | selenocysteine-containing | Drosophila melanogaster |  |
| selenium | selenocysteine-containing | Neisseria meningitidis | |
| selenium | selenocysteine-containing | Homo sapiens | |
| selenium | selenocysteine-containing | Mus musculus | |
| selenium | selenocysteine-containing | Bacillus subtilis | |
| Zinc | zinc-containing enzyme | Drosophila melanogaster | |
| Zinc | zinc-containing enzyme | Homo sapiens | |
| Zinc | zinc-containing enzyme | Mus musculus | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Bacillus subtilis | P54155 | - |
- |
| Drosophila melanogaster | - |
- |
- |
| Homo sapiens | Q8IXL7 | - |
- |
| Mus musculus | Q8BU85 | - |
- |
| Neisseria meningitidis | - |
- |
- |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| MsrA/MsrB | bifunctional enzyme EC 1.8.4.11/EC 1.8.4.12 | Neisseria meningitidis |
| MsrB | - |
Drosophila melanogaster |
| MsrB | - |
Bacillus subtilis |
| MsrB3 | - |
Mus musculus |
| MsrB3 | MsrB3 occurs in two forms, MsrB3A and MsrB3B, owing to alternative first exon splicing | Homo sapiens |
Cofactor
| Cofactor | Comment | Organism | Structure |
|---|---|---|---|
| additional information | thioredoxin independent | Homo sapiens |
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Release 2023.1 (January 2023)
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