Activating Compound | Comment | Organism | Structure |
---|---|---|---|
additional information | heat shock, dehydration, and reactive oxygen species like H2O2 induce the expression of MsrB | Arabidopsis thaliana | |
additional information | starvation induces MsrB expression, also heat treatment and methylmethanesulfonate induce the enzyme | Saccharomyces cerevisiae |
Protein Variants | Comment | Organism |
---|---|---|
additional information | cells lacking MsrB show increased sensitivity to oxidative damage, and methionine-(R)-S-oxide accumulation | Arabidopsis thaliana |
additional information | construction of MsrB null mutant and of overexpressing strains, phenotypes, overview | Mus musculus |
additional information | yeast cells lacking MsrB show increased sensitivity to oxidative damage, and methionine-(R)-S-oxide accumulation | Saccharomyces cerevisiae |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
cytosol | isozyme MsrB1 | Mus musculus | 5829 | - |
cytosol | isozyme MsrB1 | Homo sapiens | 5829 | - |
endoplasmic reticulum | isozyme MsrB3 | Mus musculus | 5783 | - |
endoplasmic reticulum | isozyme MsrB3 | Homo sapiens | 5783 | - |
intracellular | - |
Saccharomyces cerevisiae | 5622 | - |
intracellular | - |
Arabidopsis thaliana | 5622 | - |
mitochondrion | isozymes MsrB2 and MsrB3 | Mus musculus | 5739 | - |
mitochondrion | isozymes MsrB2 and MsrB3 | Homo sapiens | 5739 | - |
additional information | subcellular targeting is determined by alternative splicing | Mus musculus | - |
- |
additional information | subcellular targeting is determined by alternative splicing | Homo sapiens | - |
- |
nucleus | isozyme MsrB1 | Mus musculus | 5634 | - |
nucleus | isozyme MsrB1 | Homo sapiens | 5634 | - |
Metals/Ions | Comment | Organism | Structure |
---|---|---|---|
additional information | the major isozyme of MsrB, MsrB1, is a selenoprotein, selenium affects the expression of MsrB | Mus musculus | |
additional information | the major isozyme of MsrB, MsrB1, is a selenoprotein, selenium affects the expression of MsrB | Homo sapiens | |
additional information | the major isozyme of MsrB, MsrB1, is a selenoprotein, selenium affects the expression of MsrB | Saccharomyces cerevisiae | |
additional information | the major isozyme of MsrB, MsrB1, is a selenoprotein, selenium affects the expression of MsrB | Arabidopsis thaliana |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
L-methionine-(R)-S-oxide + thioredoxin | Mus musculus | - |
L-methionine + thioredoxin disulfide + H2O | - |
? | |
L-methionine-(R)-S-oxide + thioredoxin | Saccharomyces cerevisiae | - |
L-methionine + thioredoxin disulfide + H2O | - |
? | |
L-methionine-(R)-S-oxide + thioredoxin | Arabidopsis thaliana | substrate in vivo is e.g. the small heat shock protein Hsp-21 which loses its chaperone-like activity upon methionine oxidation | L-methionine + thioredoxin disulfide + H2O | - |
? | |
L-methionine-(R)-S-oxide + thioredoxin | Homo sapiens | substrates are HIV-2, which is inactivated by oxidation of its methionine residues M76 and M95, the potassium channel of the brain, the inhibitor IkappaB-alpha, or calmodulin, overview | L-methionine + thioredoxin disulfide + H2O | - |
? | |
additional information | Arabidopsis thaliana | roles of methionine sulfoxide reductases in antioxidant defense, protein regulation via alternating it between active and inactive form, and survival, MsrB protects cells from the cytotoxic effects of reactive oxygen species, ROS, overview | ? | - |
? | |
additional information | Mus musculus | roles of methionine sulfoxide reductases in antioxidant defense, protein regulation via alternating it between active and inactive form, and survival, MsrB protects cells from the cytotoxic effects of reactive oxygen species, ROS, overview, enzyme involvement in protein repair and associated factors, protein regulation pathway, overview | ? | - |
? | |
additional information | Saccharomyces cerevisiae | roles of methionine sulfoxide reductases in antioxidant defense, protein regulation via alternating it between active and inactive form, and survival, MsrB protects cells from the cytotoxic effects of reactive oxygen species, ROS, overview, regulation of MsrB expression, overview | ? | - |
? | |
additional information | Homo sapiens | roles of methionine sulfoxide reductases in antioxidant defense, protein regulation via alternating it between active and inactive form, and survival, MsrB protects cells from the cytotoxic effects of reactive oxygen species, ROS, overview, the enzyme is involved in age-related diseases such as Alzheimer's or Parkinson's diseases as well as in diseases caused by prions, mechanism, overview, enzyme involvement in protein repair and associated factors, protein regulation pathway, overview | ? | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Arabidopsis thaliana | - |
isozymes MsrB1-3 | - |
Homo sapiens | - |
isozymes MsrB1-3 | - |
Mus musculus | - |
isozymes MsrB1-3 | - |
Saccharomyces cerevisiae | - |
isozymes MsrB1-3 | - |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
brain | - |
Mus musculus | - |
brain | - |
Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
L-methionine-(R)-S-oxide + thioredoxin | - |
Mus musculus | L-methionine + thioredoxin disulfide + H2O | - |
? | |
L-methionine-(R)-S-oxide + thioredoxin | - |
Saccharomyces cerevisiae | L-methionine + thioredoxin disulfide + H2O | - |
? | |
L-methionine-(R)-S-oxide + thioredoxin | stereospecific reduction | Mus musculus | L-methionine + thioredoxin disulfide + H2O | - |
? | |
L-methionine-(R)-S-oxide + thioredoxin | stereospecific reduction | Homo sapiens | L-methionine + thioredoxin disulfide + H2O | - |
? | |
L-methionine-(R)-S-oxide + thioredoxin | stereospecific reduction | Saccharomyces cerevisiae | L-methionine + thioredoxin disulfide + H2O | - |
? | |
L-methionine-(R)-S-oxide + thioredoxin | stereospecific reduction | Arabidopsis thaliana | L-methionine + thioredoxin disulfide + H2O | - |
? | |
L-methionine-(R)-S-oxide + thioredoxin | substrate in vivo is e.g. the small heat shock protein Hsp-21 which loses its chaperone-like activity upon methionine oxidation | Arabidopsis thaliana | L-methionine + thioredoxin disulfide + H2O | - |
? | |
L-methionine-(R)-S-oxide + thioredoxin | substrates are HIV-2, which is inactivated by oxidation of its methionine residues M76 and M95, the potassium channel of the brain, the inhibitor IkappaB-alpha, or calmodulin, overview | Homo sapiens | L-methionine + thioredoxin disulfide + H2O | - |
? | |
additional information | roles of methionine sulfoxide reductases in antioxidant defense, protein regulation via alternating it between active and inactive form, and survival, MsrB protects cells from the cytotoxic effects of reactive oxygen species, ROS, overview | Arabidopsis thaliana | ? | - |
? | |
additional information | roles of methionine sulfoxide reductases in antioxidant defense, protein regulation via alternating it between active and inactive form, and survival, MsrB protects cells from the cytotoxic effects of reactive oxygen species, ROS, overview, enzyme involvement in protein repair and associated factors, protein regulation pathway, overview | Mus musculus | ? | - |
? | |
additional information | roles of methionine sulfoxide reductases in antioxidant defense, protein regulation via alternating it between active and inactive form, and survival, MsrB protects cells from the cytotoxic effects of reactive oxygen species, ROS, overview, regulation of MsrB expression, overview | Saccharomyces cerevisiae | ? | - |
? | |
additional information | roles of methionine sulfoxide reductases in antioxidant defense, protein regulation via alternating it between active and inactive form, and survival, MsrB protects cells from the cytotoxic effects of reactive oxygen species, ROS, overview, the enzyme is involved in age-related diseases such as Alzheimer's or Parkinson's diseases as well as in diseases caused by prions, mechanism, overview, enzyme involvement in protein repair and associated factors, protein regulation pathway, overview | Homo sapiens | ? | - |
? | |
additional information | the enzyme utilizes free and protein-bound methionine-(R)-S-oxide as substrate, but prefers the latter, methionine oxidation inactivates the proteins showing equal distribution of S-MetO and R-MetO | Mus musculus | ? | - |
? | |
additional information | the enzyme utilizes free and protein-bound methionine-(R)-S-oxide as substrate, but prefers the latter, methionine oxidation inactivates the proteins showing equal distribution of S-MetO and R-MetO | Homo sapiens | ? | - |
? | |
additional information | the enzyme utilizes free and protein-bound methionine-(R)-S-oxide as substrate, but prefers the latter, methionine oxidation inactivates the proteins showing equal distribution of S-MetO and R-MetO | Saccharomyces cerevisiae | ? | - |
? | |
additional information | the enzyme utilizes free and protein-bound methionine-(R)-S-oxide as substrate, but prefers the latter, methionine oxidation inactivates the proteins showing equal distribution of S-MetO and R-MetO | Arabidopsis thaliana | ? | - |
? |
Synonyms | Comment | Organism |
---|---|---|
methionine sulfoxide reductase B | - |
Mus musculus |
methionine sulfoxide reductase B | - |
Homo sapiens |
methionine sulfoxide reductase B | - |
Saccharomyces cerevisiae |
methionine sulfoxide reductase B | - |
Arabidopsis thaliana |
More | the enzyme belongs to the Msr family of enzymes | Mus musculus |
More | the enzyme belongs to the Msr family of enzymes | Homo sapiens |
More | the enzyme belongs to the Msr family of enzymes | Saccharomyces cerevisiae |
More | the enzyme belongs to the Msr family of enzymes | Arabidopsis thaliana |
MsrB | - |
Mus musculus |
MsrB | - |
Homo sapiens |
MsrB | - |
Saccharomyces cerevisiae |
MsrB | - |
Arabidopsis thaliana |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
thioredoxin | - |
Mus musculus | |
thioredoxin | - |
Homo sapiens | |
thioredoxin | - |
Saccharomyces cerevisiae | |
thioredoxin | - |
Arabidopsis thaliana |