Literature summary for 1.8.4.12 extracted from

Schallreuter, K.U.; Rubsam, K.; Chavan, B.; Zothner, C.; Gillbro, J.M.; Spencer, J.D.; Wood, J.M.
Functioning methionine sulfoxide reductases A and B are present in human epidermal melanocytes in the cytosol and in the nucleus (2006), Biochem. Biophys. Res. Commun., 342, 145-152.

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Cloned(Commentary)

Cloned (Comment)	Organism
expression analysis in subcellular fractions of melanocytes, overview	Homo sapiens

Localization

Localization	Comment	Organism	GeneOntology No.	Textmining
cytosol	-	Homo sapiens	5829	-
nucleus	-	Homo sapiens	5634	-

Natural Substrates/ Products (Substrates)

Natural Substrates	Organism	Comment (Nat. Sub.)	Natural Products	Comment (Nat. Pro.)	Rev.	Reac.
L-methionine-(R)-S-oxide + thioredoxin	Homo sapiens	MsrB is involved in regulation of protein function and in elimination of reactive oxygen species via reversible methionine formation besides protein repair in human skin	L-methionine + thioredoxin disulfide + H2O	-	r

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	-	several splicing variants resulting in three isozymes MsrB1-3	-

Purification (Commentary)

Purification (Comment)	Organism
partially by subcellular fractionation	Homo sapiens

Source Tissue

Source Tissue	Comment	Organism	Textmining
epidermis	-	Homo sapiens	-
melanocyte	epidermal	Homo sapiens	-
additional information	expression analysis of MsrB isozymes	Homo sapiens	-
skin	-	Homo sapiens	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
L-methionine-(R)-S-oxide + thioredoxin	MsrB is involved in regulation of protein function and in elimination of reactive oxygen species via reversible methionine formation besides protein repair in human skin	Homo sapiens	L-methionine + thioredoxin disulfide + H2O	-	r
L-methionine-(R)-S-oxide + thioredoxin	stereospecific reduction, MsrB accepts free and protein-bound substrates	Homo sapiens	L-methionine + thioredoxin disulfide + H2O	-	r

Synonyms

Synonyms	Comment	Organism
methionine sulfoxide reductase B	-	Homo sapiens
MsrB	-	Homo sapiens

Cofactor

Cofactor	Comment	Organism	Structure
thioredoxin	-	Homo sapiens

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Release 2023.1 (January 2023)