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Literature summary for 1.8.4.12 extracted from

  • Vougier, S.; Mary, J.; Dautin, N.; Vinh, J.; Friguet, B.; Ladant, D.
    Essential role of methionine residues in calmodulin binding to Bordetelle pertussis adenylate cyclase, as probed by selective oxidation and repair by the peptide methionine sulfoxide reductases (2004), J. Biol. Chem., 279, 30210-30218.
    View publication on PubMed

Cloned(Commentary)

Cloned (Comment) Organism
expression of MsrB in Escherichia coli strain BL21(DE3) Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
calmodulin-L-methionine (R)-sulfoxide + thioredoxin Homo sapiens MsrB is specific for the R-form, enzyme provides protection against oxidative damage by reactive oxygen species and has a repair function for oxidized protein methionine residues, which restores the calmodulin binding to adenylate cyclase of the pathogen Bordetella pertussis, which is an essential step for the bacterium to enter host cells, overview calmodulin-L-methionine + thioredoxin disulfide + H2O
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Organism

Organism UniProt Comment Textmining
Homo sapiens
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Purification (Commentary)

Purification (Comment) Organism
recombinant MsrB from Escherichia coli strain BL21(DE3) Homo sapiens

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
calmodulin-L-methionine (R)-sulfoxide + thioredoxin MsrB is specific for the R-form, enzyme provides protection against oxidative damage by reactive oxygen species and has a repair function for oxidized protein methionine residues, which restores the calmodulin binding to adenylate cyclase of the pathogen Bordetella pertussis, which is an essential step for the bacterium to enter host cells, overview Homo sapiens calmodulin-L-methionine + thioredoxin disulfide + H2O
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calmodulin-L-methionine (R)-sulfoxide + thioredoxin MsrB is specific for the R-form, recombinant human calmodulin, recombinant human enzyme, artificial system, determination of oxidized methionine residues being reduced by the enzyme, overview Homo sapiens calmodulin-L-methionine + thioredoxin disulfide + H2O
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Synonyms

Synonyms Comment Organism
MsrB
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Homo sapiens
peptide methionine sulfoxide reductase
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Homo sapiens

Cofactor

Cofactor Comment Organism Structure
thioredoxin
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Homo sapiens