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Literature summary for 1.8.4.11 extracted from

  • Dun, Y.; Vargas, J.; Brot, N.; Finnemann, S.C.
    Independent roles of methionine sulfoxide reductase A in mitochondrial ATP synthesis and as antioxidant in retinal pigment epithelial cells (2013), Free Radic. Biol. Med., 65, 1340-1351 .
    View publication on PubMedView publication on EuropePMC
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Localization

Localization Comment Organism GeneOntology No. Textmining
cytosol
-
 Rattus norvegicus 5829
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mitochondrion
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 Rattus norvegicus 5739
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Organism

Organism UniProt Comment Textmining
Rattus norvegicus
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
epithelium retinal pigment epithelium Rattus norvegicus
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retina retinal pigment epithelium Rattus norvegicus
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General Information

General Information Comment Organism
physiological function overexpression or silencing of the MsrA gene increases or decreases, respectively, photoreceptor outer segment fragments binding as well as engulfment in retinal pigment epithelium. These effects are independent of the levels of oxidative stress. Altering MsrA expression has no effect on phagocytosis when mitochondrial respiration is inhibited. ATP content directly correlates with MsrA protein levels in retinal pigment epithelium cells when using mitochondrial oxidative phosphorylation for ATP synthesis. Overexpressing MsrA is sufficient to increase specifically the activity of complex-IV of the respiratory chain Rattus norvegicus