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Literature summary for 1.8.4.11 extracted from
- Methionine sulfoxide reductase A is a stereospecific methionine oxidase (2011), Proc. Natl. Acad. Sci. USA, 108, 10472-10477.
Molecular Weight [Da]
| Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
|---|---|---|---|
| 23649 | - |
x * 23649, calculated from amino acid sequence | Homo sapiens |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| L-methionine (S)-sulfoxide + thioredoxin | Homo sapiens | the enzyme is specific for the S epimer of methionine sulfoxide | L-methionine + thioredoxin disulfide + H2O | - |
r |  |
| additional information | Homo sapiens | the enzyme catalyzes its own autooxidation as well as oxidation of free methionine and methionine residues in peptides and proteins | ? | - |
? | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Homo sapiens | - |
- |
- |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| alpha-synuclein + dithiothreitol | alpha-synuclein is oxidized at both Met1 and Met5 but not at Met116 or Met127 | Homo sapiens | ? | - |
? | |
| Gly-L-Met-Gly + dithiothreitol | - |
Homo sapiens | ? | - |
? | |
| L-methionine (S)-sulfoxide + thioredoxin | the enzyme is specific for the S epimer of methionine sulfoxide | Homo sapiens | L-methionine + thioredoxin disulfide + H2O | - |
r | |
| L-Pro-L-Met-L-Ala-L-Ile-L-Lys-L-Lys + dithiothreitol | - |
Homo sapiens | ? | - |
? | |
| additional information | the enzyme catalyzes its own autooxidation as well as oxidation of free methionine and methionine residues in peptides and proteins | Homo sapiens | ? | - |
? | |
Subunits
| Subunits | Comment | Organism |
|---|---|---|
| ? | x * 23649, calculated from amino acid sequence | Homo sapiens |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| methionine sulfoxide reductase A | - |
Homo sapiens |
| MsrA | - |
Homo sapiens |
Cofactor
| Cofactor | Comment | Organism | Structure |
|---|---|---|---|
| thioredoxin | - |
Homo sapiens | |
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Release 2023.1 (January 2023)
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