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Literature summary for 1.8.4.11 extracted from

  • Kim, J.I.; Choi, S.H.; Jung, K.J.; Lee, E.; Kim, H.Y.; Park, K.M.
    Protective role of methionine sulfoxide reductase A against ischemia/reperfusion injury in mouse kidney and its involvement in the regulation of trans-sulfuration pathway (2013), Antioxid. Redox Signal., 18, 2241-2250.
    View publication on PubMedView publication on EuropePMC

Organism

Organism UniProt Comment Textmining
Mus musculus
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-
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Source Tissue

Source Tissue Comment Organism Textmining

Synonyms

Synonyms Comment Organism
methionine sulfoxide reductase A
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Mus musculus
MsrA
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Mus musculus

Cofactor

Cofactor Comment Organism Structure
thioredoxin
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Mus musculus

General Information

General Information Comment Organism
malfunction enzyme-deficient mice are more susceptible to kidney ischemia/reperfusion injury than wild type mice. Deletion of the enzyme enhances renal functional and morphological impairments, congestion, inflammatory responses, and oxidative stress under ischemia/reperfusion conditions Mus musculus
metabolism the enzyme participates in regulating methionine metabolism and the trans-sulfuration pathway under normal and ischemia/reperfusion conditions Mus musculus
physiological function the enzyme protects the kidney against ischemia/reperfusion injury. This protection is associated with reduced oxidative stress and inflammatory responses. The enzyme regulates H2S production during ischemia/reperfusion by modulating the expression and activity of the cystathionine-beta-synthase and cystathionine-gamma-lyase enzymes Mus musculus