Literature summary for 1.8.4.11 extracted from

Le, H.T.; Chaffotte, A.F.; Demey-Thomas, E.; Vinh, J.; Friguet, B.; Mary, J.
Impact of hydrogen peroxide on the activity, structure, and conformational stability of the oxidized protein repair enzyme methionine sulfoxide reductase A (2009), J. Mol. Biol., 393, 58-66.

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Cloned(Commentary)

Cloned (Comment)	Organism
expressed in Escherichia coli	Rattus norvegicus

Inhibitors

Inhibitors	Comment	Organism	Structure
H2O2	the enzyme is only inactivated by high doses of H2O2, when treated with 0.5 mM H2O2 MsrA loses 20% of its activity and this inhibition reaches approximately 40% with 1 mM H2O2, MsrA is not significantly inhibited by lower concentrations of H2O2 (0.050 and 0.1 mM)	Rattus norvegicus

Organism

Organism	UniProt	Comment	Textmining
Rattus norvegicus	Q923M1	-	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
N-acetyl-L-methionine (S)-sulfoxide + thioredoxin	-	Rattus norvegicus	N-acetyl-L-methionine + thioredoxin disulfide + H2O	-	?

Synonyms

Synonyms	Comment	Organism
methionine sulfoxide reductase A	-	Rattus norvegicus
MsrA	-	Rattus norvegicus

Cofactor

Cofactor	Comment	Organism	Structure
thioredoxin	-	Rattus norvegicus

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Release 2023.1 (January 2023)