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Literature summary for 1.8.4.11 extracted from

  • Pascual, I.; Larrayoz, I.M.; Rodriguez, I.R.
    Retinoic acid regulates the human methionine sulfoxide reductase A (MSRA) gene via two distinct promoters (2009), Genomics, 93, 62-71.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 1.8.4.11

Localization

Localization Comment Organism GeneOntology No. Textmining
cytosol
-
 Homo sapiens 5829
-
mitochondrion
-
 Homo sapiens 5739
-
nucleus
-
 Homo sapiens 5634
-

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
L-methionine (S)-sulfoxide + thioredoxin Homo sapiens
-
 L-methionine + thioredoxin disulfide + H2O
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens Q9UJ68
-
-

Source Tissue

Source Tissue Comment Organism Textmining
brain
-
 Homo sapiens
-
D-407 cell
-
 Homo sapiens
-
HEK-293 cell
-
 Homo sapiens
-
kidney
-
 Homo sapiens
-
SH-SY5Y cell
-
 Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
L-methionine (S)-sulfoxide + thioredoxin
-
 Homo sapiens L-methionine + thioredoxin disulfide + H2O
-
 ?

Synonyms

Synonyms Comment Organism
methionine sulfoxide reductase A
-
 Homo sapiens
MsrA
-
 Homo sapiens

Cofactor

Cofactor Comment Organism Structure
thioredoxin
-
 Homo sapiens

Expression

Organism Comment Expression
Homo sapiens the upstream (promoter 1) regulates the msrA1 transcript that codes for the mitochondrial form of MSRA, the downstream promoter (promoter 2) regulates the msrA2/3 transcripts that code for the cytosolic/nuclear forms of MSRA and is generally less active, both promoters are partially regulated by all-trans retinoic acid up