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Literature summary for 1.8.4.11 extracted from

  • Minniti, A.N.; Cataldo, R.; Trigo, C.; Vasquez, L.; Mujica, P.; Leighton, F.; Inestrosa, N.C.; Aldunate, R.
    Methionine sulfoxide reductase A expression is regulated by the DAF-16/FOXO pathway in Caenorhabditis elegans (2009), Aging Cell, 8, 690-705.
    View publication on PubMed
Search for more literature for 1.8.4.11

Organism

Organism UniProt Comment Textmining
Caenorhabditis elegans
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-
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Caenorhabditis elegans N2
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-
-

Source Tissue

Source Tissue Comment Organism Textmining
hypodermis weak expression in the hypodermis Caenorhabditis elegans
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intestine the msra-1 gene is expressed in most tissues, particularly in the intestine Caenorhabditis elegans
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nervous system the msra-1 gene is expressed in most tissues, particularly in the nervous system Caenorhabditis elegans
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neuron occasional expression in neurons Caenorhabditis elegans
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Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
dabsyl-L-methionine (S)-sulfoxide + thioredoxin
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 Caenorhabditis elegans ?
-
 ?
dabsyl-L-methionine (S)-sulfoxide + thioredoxin
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 Caenorhabditis elegans N2 ?
-
 ?

Synonyms

Synonyms Comment Organism
methionine sulfoxide reductase A
-
 Caenorhabditis elegans
MsrA
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 Caenorhabditis elegans
MSRA-1
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 Caenorhabditis elegans

Cofactor

Cofactor Comment Organism Structure
thioredoxin
-
 Caenorhabditis elegans

Expression

Organism Comment Expression
Caenorhabditis elegans msra-1 mRNA is increased by 2fold in daf-2 mutants compared to wild type controls when worms are cultured at 23 and 25°C, there is a notorious increase in MSRA-1 activity in daf-2 mutants as the worms age, at 23°C MSRA-1 expression is dramatically enhanced in the nervous system up

General Information

General Information Comment Organism
physiological function MSRA-1 is involved in the aging process in Caenorhabditis elegans, worms carrying a deletion of the msra-1 gene are more sensitive to oxidative stress, show chemotaxis and locomotory defects, and a 30% decrease in median survival Caenorhabditis elegans