Organism | UniProt | Comment | Textmining |
---|---|---|---|
Mus musculus | Q9D6Y7 | - |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
brain | MsrA-/- mice have compromised complex task learning capabilities relative to wild-type mice. MsrA-/- mice exhibit lower locomotor activity and altered gait that exacerbate with age. MsrA-/- mice are less responsive to amphetamine treatment. Relative to wild-type mice, MsrA-/- brains contain significantly higher levels of dopamine up to 12 months of age, while lower levels of dopamine are observed at 16 months of age. Striatal regions of MsrA-/- mice show an increase of dopamine release parallel to observed dopamine levels. It is suggested that dopamine regulation and signaling pathways are impaired in MsrA-/- mice, which may contribute to their abnormal behavior | Mus musculus | - |
Synonyms | Comment | Organism |
---|---|---|
MsrA | - |
Mus musculus |