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BRENDA support

Literature summary for 1.8.4.11 extracted from

  • Oien, D.B.; Osterhaus, G.L.; Latif, S.A.; Pinkston, J.W.; Fulks, J.; Johnson, M.; Fowler, S.C.; Moskovitz, J.
    MsrA knockout mouse exhibits abnormal behavior and brain dopamine levels (2008), Free Radic. Biol. Med., 45, 193-200.
    View publication on PubMedView publication on EuropePMC

Organism

Organism UniProt Comment Textmining
Mus musculus Q9D6Y7
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Source Tissue

Source Tissue Comment Organism Textmining
brain MsrA-/- mice have compromised complex task learning capabilities relative to wild-type mice. MsrA-/- mice exhibit lower locomotor activity and altered gait that exacerbate with age. MsrA-/- mice are less responsive to amphetamine treatment. Relative to wild-type mice, MsrA-/- brains contain significantly higher levels of dopamine up to 12 months of age, while lower levels of dopamine are observed at 16 months of age. Striatal regions of MsrA-/- mice show an increase of dopamine release parallel to observed dopamine levels. It is suggested that dopamine regulation and signaling pathways are impaired in MsrA-/- mice, which may contribute to their abnormal behavior Mus musculus
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Synonyms

Synonyms Comment Organism
MsrA
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Mus musculus