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Literature summary for 1.8.4.11 extracted from
- Impairment of methionine sulfoxide reductase during UV irradiation and photoaging (2007), Exp. Gerontol., 42, 859-863.
Localization
| Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|
| cytosol | - |
Mus musculus | 5829 | - |
| cytosol | - |
Rattus norvegicus | 5829 | - |
| cytosol | - |
Homo sapiens | 5829 | - |
| mitochondrion | - |
Mus musculus | 5739 | - |
| mitochondrion | - |
Rattus norvegicus | 5739 | - |
| mitochondrion | - |
Homo sapiens | 5739 | - |
| nucleus | - |
Mus musculus | 5634 | - |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| additional information | Mus musculus | MsrA null mutant mice exhibit a shortened lifespan and present higher levels of protein carbonyls when exposed to hyperoxia, which indicates an increased sensitivity towards oxidative stress | ? | - |
? |  |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Homo sapiens | Q9UJ68 | - |
- |
| Mus musculus | - |
- |
- |
| Rattus norvegicus | - |
- |
- |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| alveolar macrophage | - |
Rattus norvegicus | - |
| blood | - |
Rattus norvegicus | - |
| cerebellum | - |
Homo sapiens | - |
| epidermis | chronic sun exposure of human epidermis and high dose UVA irradiation of cultured human keratinocytes results in a decline of MsrA expression and/or Msr activity | Homo sapiens | - |
| fibroblast | overexpression of MsrA protects immortalized WI-38 SV40 human fibroblasts against H2O2mediated oxidative stress by reducing the amount of intracellular reactive oxygen species and the extent of irreversible protein oxidative damage | Homo sapiens | - |
| keratinocyte | chronic sun exposure of human epidermis and high dose UVA irradiation of cultured human keratinocytes results in a decline of MsrA expression and/or Msr activity | Homo sapiens | - |
| kidney | - |
Rattus norvegicus | - |
| kidney | MsrA mRNA is highly expressed | Homo sapiens | - |
| lens | - |
Homo sapiens | - |
| liver | - |
Homo sapiens | - |
| melanocyte | - |
Homo sapiens | - |
| nervous system | - |
Rattus norvegicus | - |
| neuron | - |
Rattus norvegicus | - |
| renal medulla | - |
Rattus norvegicus | - |
| retinal pigment epithelium | - |
Rattus norvegicus | - |
| skin | MsrA exhibits a strong expression in keratinocytes and melanocytes and a lower expression in dermal fibroblasts. Repetitive exposure of human skin to solar-stimulated light results in an enhanced expression of MsrA in the epidermis. Exposure to relatively high doses of UVA results in a downregulation of MsrA. Chronic sun-exposure, would result in a decreased expression of two main components of the methionine sulfoxide reductase system, MsrA and MsrB2 | Homo sapiens | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| additional information | MsrA null mutant mice exhibit a shortened lifespan and present higher levels of protein carbonyls when exposed to hyperoxia, which indicates an increased sensitivity towards oxidative stress | Mus musculus | ? | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| MsrA | - |
Mus musculus |
| MsrA | - |
Rattus norvegicus |
| MsrA | - |
Homo sapiens |
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Release 2023.1 (January 2023)
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