Cloned (Comment) | Organism |
---|---|
gene msrA, DNA and amino acid sequence determination and analysis | Aggregatibacter actinomycetemcomitans |
Protein Variants | Comment | Organism |
---|---|---|
additional information | msrA gene inactivation by chromosomal insertion via allele replacement mutagenesis does not lead to increased sensitivity against oxidative stress but to complete loss of enzymatic activity with synthetic substrates | Aggregatibacter actinomycetemcomitans |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
cytosol | subcellular localization analysis, overview | Aggregatibacter actinomycetemcomitans | 5829 | - |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
additional information | Aggregatibacter actinomycetemcomitans | the enzyme is not a major virulence determinant in the oral pathogen, MsrA is required for protein repair and protection against oxidative damage as well as for the proper expression or maintenance of functional adhesins | ? | - |
? | |
peptide-L-methionine-(S)-S-oxide + thioredoxin | Aggregatibacter actinomycetemcomitans | stereospecific reduction | peptide-L-methionine + thioredoxin disulfide + H2O | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Aggregatibacter actinomycetemcomitans | Q9AL99 | strains VT1169 and VT1530 derived from the clinical strain SUNY 465 | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
dabsyl-L-methionine-(S)-S-oxide + DTT | stereospecific reduction | Aggregatibacter actinomycetemcomitans | dabsyl-L-methionine + DTT disulfide + H2O | - |
? | |
additional information | the enzyme is not a major virulence determinant in the oral pathogen, MsrA is required for protein repair and protection against oxidative damage as well as for the proper expression or maintenance of functional adhesins | Aggregatibacter actinomycetemcomitans | ? | - |
? | |
peptide-L-methionine-(S)-S-oxide + thioredoxin | stereospecific reduction | Aggregatibacter actinomycetemcomitans | peptide-L-methionine + thioredoxin disulfide + H2O | - |
? |
Synonyms | Comment | Organism |
---|---|---|
MsrA | - |
Aggregatibacter actinomycetemcomitans |
peptide methionine sulfoxide reductase | - |
Aggregatibacter actinomycetemcomitans |
Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
---|---|---|---|
37 | - |
assay at | Aggregatibacter actinomycetemcomitans |
pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
---|---|---|---|
7.4 | - |
assay at | Aggregatibacter actinomycetemcomitans |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
dithiothreitol | - |
Aggregatibacter actinomycetemcomitans |