Activating Compound | Comment | Organism | Structure |
---|---|---|---|
additional information | MsrA is upregulated by UVA radiation in keratinocytes | Homo sapiens |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
peptide-L-methionine-(S)-S-oxide + thioredoxin | Homo sapiens | the enzyme protects the epidermis cells against irradiation and oxidative damages, overview | peptide-L-methionine + thioredoxin disulfide + H2O | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
female caucasian individuals | - |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
epidermis | - |
Homo sapiens | - |
HaCaT cell | primary keratinocytes, expression level at normal light and UV-light conditions | Homo sapiens | - |
skin | accumulation in the upper dermis | Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
His6-Ala-Ala-Gln-MetO-Ile + DTT | - |
Homo sapiens | His6-Ala-Ala-Gln-Met-Ile + DTT disulfide + H2O | - |
? | |
peptide-L-methionine-(S)-S-oxide + thioredoxin | stereospecific reduction | Homo sapiens | peptide-L-methionine + thioredoxin disulfide + H2O | - |
? | |
peptide-L-methionine-(S)-S-oxide + thioredoxin | the enzyme protects the epidermis cells against irradiation and oxidative damages, overview | Homo sapiens | peptide-L-methionine + thioredoxin disulfide + H2O | - |
? |
Synonyms | Comment | Organism |
---|---|---|
MsrA | - |
Homo sapiens |
peptide methionine S-sulfoxide reductase | - |
Homo sapiens |
Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
---|---|---|---|
37 | - |
assay at | Homo sapiens |
pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
---|---|---|---|
7.5 | - |
assay at | Homo sapiens |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
dithiothreitol | - |
Homo sapiens | |
thioredoxin | - |
Homo sapiens |