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Literature summary for 1.8.4.11 extracted from

  • Ogawa, F.; Sander, C.S.; Hansel, A.; Oehrl, W.; Kasperczyk, H.; Elsner, P.; Shimizu, K.; Heinemann, S.H.; Thiele, J.J.
    The repair enzyme peptide methionine-S-sulfoxide reductase is expressed in human epidermis and upregulated by UVA radiation (2006), J. Invest. Dermatol., 126, 1128-1134.
    View publication on PubMed

Activating Compound

Activating Compound Comment Organism Structure
additional information MsrA is upregulated by UVA radiation in keratinocytes Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
peptide-L-methionine-(S)-S-oxide + thioredoxin Homo sapiens the enzyme protects the epidermis cells against irradiation and oxidative damages, overview peptide-L-methionine + thioredoxin disulfide + H2O
-
?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
female caucasian individuals
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Source Tissue

Source Tissue Comment Organism Textmining
epidermis
-
Homo sapiens
-
HaCaT cell primary keratinocytes, expression level at normal light and UV-light conditions Homo sapiens
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skin accumulation in the upper dermis Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
His6-Ala-Ala-Gln-MetO-Ile + DTT
-
Homo sapiens His6-Ala-Ala-Gln-Met-Ile + DTT disulfide + H2O
-
?
peptide-L-methionine-(S)-S-oxide + thioredoxin stereospecific reduction Homo sapiens peptide-L-methionine + thioredoxin disulfide + H2O
-
?
peptide-L-methionine-(S)-S-oxide + thioredoxin the enzyme protects the epidermis cells against irradiation and oxidative damages, overview Homo sapiens peptide-L-methionine + thioredoxin disulfide + H2O
-
?

Synonyms

Synonyms Comment Organism
MsrA
-
Homo sapiens
peptide methionine S-sulfoxide reductase
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Homo sapiens

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
37
-
assay at Homo sapiens

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
7.5
-
assay at Homo sapiens

Cofactor

Cofactor Comment Organism Structure
dithiothreitol
-
Homo sapiens
thioredoxin
-
Homo sapiens