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Literature summary for 1.8.4.11 extracted from

  • Petropoulos, I.; Friguet, B.
    Protein maintenance in aging and replicative senescence: a role for the peptide methionine sulfoxide reductases (2005), Biochim. Biophys. Acta, 1703, 261-266.
    View publication on PubMed

Cloned(Commentary)

Cloned (Comment) Organism
mitochondrial and cytosolic isozymes are encoded on a single gene with 2 initiations sites, delivering an N-terminal signal peptide to the mitochondrial enzyme form Rattus norvegicus

Protein Variants

Protein Variants Comment Organism
additional information overexpression of MsrA leads to extended life span of the flies up to 70%, the resistance against paraquat-induced oxidative stress is increased Drosophila melanogaster

Localization

Localization Comment Organism GeneOntology No. Textmining
cytosol
-
Rattus norvegicus 5829
-
mitochondrion matrix Rattus norvegicus 5739
-

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
L-methionine (S)-sulfoxide + thioredoxin Drosophila melanogaster MsrA is specific for the S-form L-methionine + thioredoxin disulfide + H2O
-
?
L-methionine (S)-sulfoxide + thioredoxin Escherichia coli MsrA is specific for the S-form L-methionine + thioredoxin disulfide + H2O
-
?
L-methionine (S)-sulfoxide + thioredoxin Homo sapiens MsrA is specific for the S-form L-methionine + thioredoxin disulfide + H2O
-
?
L-methionine (S)-sulfoxide + thioredoxin Rattus norvegicus MsrA is specific for the S-form L-methionine + thioredoxin disulfide + H2O
-
?
L-methionine (S)-sulfoxide + thioredoxin Saccharomyces cerevisiae MsrA is specific for the S-form L-methionine + thioredoxin disulfide + H2O
-
?
additional information Escherichia coli cellular system of balancing native proteins and oxidatively damaged proteins by use of protein biosynthesis, protein oxidative modification, protein elimination, and oxidized protein repair involving the enzyme, overview, enzyme protects against oxidative damage of proteins ?
-
?
additional information Saccharomyces cerevisiae cellular system of balancing native proteins and oxidatively damaged proteins by use of protein biosynthesis, protein oxidative modification, protein elimination, and oxidized protein repair involving the enzyme, overview, enzyme protects against oxidative damage of proteins, enzyme activity is not age-related ?
-
?
additional information Drosophila melanogaster cellular system of balancing native proteins and oxidatively damaged proteins by use of protein biosynthesis, protein oxidative modification, protein elimination, and oxidized protein repair involving the enzyme, overview, enzyme protects against oxidative damage of proteins, loss of enzyme activity is age-related ?
-
?
additional information Homo sapiens cellular system of balancing native proteins and oxidatively damaged proteins by use of protein biosynthesis, protein oxidative modification, protein elimination, and oxidized protein repair involving the enzyme, overview, enzyme protects against oxidative damage of proteins, loss of enzyme activity is age-related ?
-
?
additional information Rattus norvegicus cellular system of balancing native proteins and oxidatively damaged proteins by use of protein biosynthesis, protein oxidative modification, protein elimination, and oxidized protein repair involving the enzyme, overview, enzyme protects against oxidative damage of proteins, loss of enzyme activity is age-related ?
-
?

Organism

Organism UniProt Comment Textmining
Drosophila melanogaster
-
-
-
Escherichia coli
-
-
-
Homo sapiens
-
-
-
Rattus norvegicus
-
-
-
Saccharomyces cerevisiae
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
brain MsrA Rattus norvegicus
-
fibroblast cell line WI-38, young and old cells, enzyme expression pattern during cell development, senescent cells show decreased enzyme expression and activity Homo sapiens
-
kidney MsrA Rattus norvegicus
-
liver MsrA Rattus norvegicus
-
additional information organ-specific expression patterns Rattus norvegicus
-
WI-38 cell fibroblast, young and old cells, enzyme expression pattern during cell development Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
L-methionine (S)-sulfoxide + thioredoxin MsrA is specific for the S-form Drosophila melanogaster L-methionine + thioredoxin disulfide + H2O
-
?
L-methionine (S)-sulfoxide + thioredoxin MsrA is specific for the S-form Escherichia coli L-methionine + thioredoxin disulfide + H2O
-
?
L-methionine (S)-sulfoxide + thioredoxin MsrA is specific for the S-form Homo sapiens L-methionine + thioredoxin disulfide + H2O
-
?
L-methionine (S)-sulfoxide + thioredoxin MsrA is specific for the S-form Rattus norvegicus L-methionine + thioredoxin disulfide + H2O
-
?
L-methionine (S)-sulfoxide + thioredoxin MsrA is specific for the S-form Saccharomyces cerevisiae L-methionine + thioredoxin disulfide + H2O
-
?
additional information cellular system of balancing native proteins and oxidatively damaged proteins by use of protein biosynthesis, protein oxidative modification, protein elimination, and oxidized protein repair involving the enzyme, overview, enzyme protects against oxidative damage of proteins Escherichia coli ?
-
?
additional information cellular system of balancing native proteins and oxidatively damaged proteins by use of protein biosynthesis, protein oxidative modification, protein elimination, and oxidized protein repair involving the enzyme, overview, enzyme protects against oxidative damage of proteins, enzyme activity is not age-related Saccharomyces cerevisiae ?
-
?
additional information cellular system of balancing native proteins and oxidatively damaged proteins by use of protein biosynthesis, protein oxidative modification, protein elimination, and oxidized protein repair involving the enzyme, overview, enzyme protects against oxidative damage of proteins, loss of enzyme activity is age-related Drosophila melanogaster ?
-
?
additional information cellular system of balancing native proteins and oxidatively damaged proteins by use of protein biosynthesis, protein oxidative modification, protein elimination, and oxidized protein repair involving the enzyme, overview, enzyme protects against oxidative damage of proteins, loss of enzyme activity is age-related Homo sapiens ?
-
?
additional information cellular system of balancing native proteins and oxidatively damaged proteins by use of protein biosynthesis, protein oxidative modification, protein elimination, and oxidized protein repair involving the enzyme, overview, enzyme protects against oxidative damage of proteins, loss of enzyme activity is age-related Rattus norvegicus ?
-
?
N-acetyl-L-methionine (S)-sulfoxide + thioredoxin MsrA is specific for the S-form Saccharomyces cerevisiae N-acetyl-L-methionine + thioredoxin disulfide + H2O
-
?

Synonyms

Synonyms Comment Organism
MsrA
-
Drosophila melanogaster
MsrA
-
Escherichia coli
MsrA
-
Homo sapiens
MsrA
-
Rattus norvegicus
MsrA
-
Saccharomyces cerevisiae
peptide methionine sulfoxide reductase
-
Drosophila melanogaster
peptide methionine sulfoxide reductase
-
Escherichia coli
peptide methionine sulfoxide reductase
-
Homo sapiens
peptide methionine sulfoxide reductase
-
Rattus norvegicus
peptide methionine sulfoxide reductase
-
Saccharomyces cerevisiae

Cofactor

Cofactor Comment Organism Structure
thioredoxin
-
Drosophila melanogaster
thioredoxin
-
Escherichia coli
thioredoxin
-
Homo sapiens
thioredoxin
-
Rattus norvegicus
thioredoxin
-
Saccharomyces cerevisiae