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Literature summary for 1.8.3.2 extracted from

  • Araujo, D.G.; Nakao, L.; Gozzo, P.; Souza, C.D.; Balderrama, V.; Gugelmin, E.S.; Kuczynski, A.P.; Olandoski, M.; de Noronha, L.
    Expression level of quiescin sulfhydryl oxidase 1 (QSOX1) in neuroblastomas (2014), Eur. J. Histochem., 58, 2228 .
    View publication on PubMedView publication on EuropePMC
Search for more literature for 1.8.3.2

Application

Application Comment Organism
diagnostics the expression of QSOX1 in neuroblastoma tumors may influence its clinical course because this protein is involved in processes such as the maturation of the extracellular matrix and the induction of apoptosis in these tumors. The enzyme can be used as a prognostic biomarker to help better discriminate among risk groups Homo sapiens

Localization

Localization Comment Organism GeneOntology No. Textmining
endoplasmic reticulum
-
 Homo sapiens 5783
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extracellular
-
 Homo sapiens
-
-
Golgi apparatus
-
 Homo sapiens 5794
-
mitochondrion
-
 Homo sapiens 5739
-
secretory granule
-
 Homo sapiens 30141
-

Organism

Organism UniProt Comment Textmining
Homo sapiens O00391
-
-

Source Tissue

Source Tissue Comment Organism Textmining
brain
-
 Homo sapiens
-
neuroblastoma cell immunohistochemical expression of the protein quiescin sulfhydryl oxidase 1 (QSOX1) in samples obtained from untreated neuroblastomas with the patients' clinical and pathological prognostic factors and clinical course. The immunoexpression of QSOX1 correlates with the type of tumor stroma and is higher in Schwannian stroma-rich tumors. Statistically significant correlation between QSOX1 expression and well-differentiated neuroblastomas Homo sapiens
-

Synonyms

Synonyms Comment Organism
QSOx1
-
 Homo sapiens
quiescin sulfhydryl oxidase 1
-
 Homo sapiens

General Information

General Information Comment Organism
physiological function the extracellular location of QSOX proteins suggests that they may be involved in the remodelling of the extracellular matrix, particularly because QSOX can catalyse the formation of disulfide bridges, which are needed for the appropriate folding and stability of various matrix proteins. The expression of QSOX1 in neuroblastoma tumors may influence its clinical course because this protein is involved in processes such as the maturation of the extracellular matrix and the induction of apoptosis in these tumors Homo sapiens