Literature summary for 1.8.3.2 extracted from

Terziyska, N.; Grumbt, B.; Bien, M.; Neupert, W.; Herrmann, J.M.; Hell, K.
The sulfhydryl oxidase Erv1 is a substrate of the Mia40-dependent protein translocation pathway (2007), FEBS Lett., 581, 1098-1102.

Search for more literature for 1.8.3.2

Application

Application	Comment	Organism
additional information	Erv1 represents a substrate of the Mia40-dependent translocation pathway	Saccharomyces cerevisiae

Protein Variants

Protein Variants	Comment	Organism
C133S	imported into mitochondria with similar efficiencies as wild-type Erv1	Saccharomyces cerevisiae
C30S	imported into mitochondria with similar efficiencies as wild-type Erv1	Saccharomyces cerevisiae
C30S/C33S	imported into mitochondria with similar efficiencies as wild-type Erv1	Saccharomyces cerevisiae

Localization

Localization	Comment	Organism	GeneOntology No.	Textmining
mitochondrion	Erv1 requires the redox-regulated receptor Mia40 for its import into mitochondria. Interacts via disulfide bonds with Mia40. It does not need two CX2C motifs for import into mitochondria	Saccharomyces cerevisiae	5739	-

Organism

Organism	UniProt	Comment	Textmining
Saccharomyces cerevisiae	-	-	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
dithiothreitol + O2	low concentrations of dithiothreitol stimulate the import efficiency of Erv1, whereas higher concentrations of dithiothreitol decrease it	Saccharomyces cerevisiae	dithiothreitol disulfide + H2O2	-	?

Synonyms

Synonyms	Comment	Organism
Erv1	-	Saccharomyces cerevisiae
sulfhydryl oxidase	-	Saccharomyces cerevisiae

Use of this online version of BRENDA is free under the CC BY 4.0 license. See terms of use for full details.

Release 2023.1 (January 2023)