Cloned (Comment) | Organism |
---|---|
gene SOXN, DNA and amino acid sequence determination, gene maps to chromosome 9q34.3, subcloning in Escherichia coli strain DH10B, in vitro-transcription and -translation | Homo sapiens |
Protein Variants | Comment | Organism |
---|---|---|
additional information | antisense constructs of the SOXN gene in Tet21N neuroblastoma cells confer resistance to IFN-gamma-induced apoptosis, while ectopic overexpression in sense direction sensitizes the cells to induced cell death | Homo sapiens |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
additional information | - |
Homo sapiens | - |
- |
nuclear membrane | asociated | Homo sapiens | 31965 | - |
plasma membrane | outer, associated | Homo sapiens | 5886 | - |
Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
---|---|---|---|
60000 | - |
x * 78000, glycosylated enzyme, x * 60000, non-glycosylated enzyme | Homo sapiens |
78000 | - |
x * 78000, glycosylated enzyme, x * 60000, non-glycosylated enzyme | Homo sapiens |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
additional information | Homo sapiens | enzyme is involved in regulation/deregulation of MYCN gene expression which is a critical determinant in neuroblastoma progression, enzyme renders the cell sensitive to IFN-gamma-induced apoptosis | ? | - |
? | |
R-SH + O2 | Homo sapiens | - |
R-S-S-R + H2O2 | - |
ir |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | Q6ZRP7 | - |
- |
Posttranslational Modification | Comment | Organism |
---|---|---|
glycoprotein | probably | Homo sapiens |
additional information | enzyme contains a signal sequence | Homo sapiens |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
additional information | tissue distribution of enzyme expression | Homo sapiens | - |
neuroblastoma cell line | several cell lines | Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
additional information | enzyme is involved in regulation/deregulation of MYCN gene expression which is a critical determinant in neuroblastoma progression, enzyme renders the cell sensitive to IFN-gamma-induced apoptosis | Homo sapiens | ? | - |
? | |
R-SH + O2 | - |
Homo sapiens | R-S-S-R + H2O2 | - |
ir |
Subunits | Comment | Organism |
---|---|---|
? | x * 78000, glycosylated enzyme, x * 60000, non-glycosylated enzyme | Homo sapiens |
More | enzyme contains a protein-disulfide-isomerase-type thioredoxin domain and a yeast ERV1 domain | Homo sapiens |
Synonyms | Comment | Organism |
---|---|---|
More | enzyme belongs to the sulfhydryl oxidase/Quiescin6 family | Homo sapiens |
neuroblastoma-derived sulfhydryl oxidase | - |
Homo sapiens |
SOXN | - |
Homo sapiens |
sulfhydryl oxidase | - |
Homo sapiens |