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Literature summary for 1.8.3.1 extracted from
- Evolutionary persistence of the molybdopyranopterin-containing sulfite oxidase protein fold (2008), Microbiol. Mol. Biol. Rev., 72, 228-48.
Crystallization (Commentary)
| Crystallization (Comment) | Organism |
|---|---|
- |
Escherichia coli |
Protein Variants
| Protein Variants | Comment | Organism |
|---|---|---|
| A208D | SUOX deficiency | Homo sapiens |
| G473D | SUOX deficiency | Homo sapiens |
| additional information | SUOX deficiency is typically inherited as a recessive autosomal trait for which there is no known therapy and typically results in death in infancy | Homo sapiens |
| R138Q | the side chain nitrogen of the Gln appears to be within the coordination sphere of the Mo | Gallus gallus |
| R160Q | mutation increases the Km for sulfite and decreases the kcat, resulting in a 1000fold decrease in catalytic efficiency. Reveals an increase in coordination number for the Mo, from 5 to 6 | Homo sapiens |
| S370Y | SUOX deficiency | Homo sapiens |
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| additional information | is inactivated in the dark via a process in which a Ser residue (Ser543) in the hinge region connecting the Mo-PPT dimerization domain with the heme b5 domain is phosphorylated, followed by binding of the NIA inhibitor protein | Spinacia oleracea |
Localization
| Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|
| cytoplasm | - |
Deinococcus radiodurans | 5737 | - |
| periplasm | - |
Thermus thermophilus | - |
- |
| periplasm | - |
Escherichia coli | - |
- |
Metals/Ions
| Metals/Ions | Comment | Organism | Structure |
|---|---|---|---|
| Mo | - |
Homo sapiens |  |
| Mo | - |
Spinacia oleracea | |
| Mo | - |
Chlorella vulgaris | |
| Mo | - |
Gallus gallus | |
| Mo | the organism is comprised of only the Mo-PPT binding SUOX fold itself | Escherichia coli | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Arabidopsis thaliana | Q9S850 | - |
- |
| Bacillus licheniformis | - |
- |
- |
| Bacillus sp. (in: Bacteria) | - |
- |
- |
| Bacillus sp. (in: Bacteria) NRRL B-14911 | - |
- |
- |
| Chlorella vulgaris | - |
- |
- |
| Deinococcus radiodurans | - |
- |
- |
| Erythrobacter litoralis | - |
- |
- |
| Escherichia coli | - |
- |
- |
| Gallus gallus | P07850 | - |
- |
| Homo sapiens | - |
- |
- |
| Maribacter sp. HTCC2170 | - |
- |
- |
| Ogataea angusta | - |
- |
- |
| Paenarthrobacter aurescens | - |
- |
- |
| Rhizorhabdus wittichii RW1 | A5V4U9 | - |
- |
| Roseovarius nubinhibens | - |
- |
- |
| Rubrobacter xylanophilus | - |
- |
- |
| Saccharopolyspora erythraea | - |
- |
- |
| Spinacia oleracea | - |
- |
- |
| Streptomyces ambofaciens | - |
- |
- |
| Thermus thermophilus | - |
- |
- |
| Zea mays | - |
- |
- |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| liver | - |
Gallus gallus | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| additional information | R138, R190, and R450 contribute to a positively charged binding pocket, which stabilizes substrate/product binding | Gallus gallus | ? | - |
? | |
Subunits
| Subunits | Comment | Organism |
|---|---|---|
| pentamer | crystallography | Escherichia coli |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| NIA | - |
Spinacia oleracea |
| NIA | - |
Zea mays |
| NIA | - |
Ogataea angusta |
| NIA | - |
Chlorella vulgaris |
| sulfite oxidase | - |
Thermus thermophilus |
| sulfite oxidase | - |
Escherichia coli |
| sulfite oxidase | - |
Homo sapiens |
| sulfite oxidase | - |
Spinacia oleracea |
| sulfite oxidase | - |
Zea mays |
| sulfite oxidase | - |
Ogataea angusta |
| sulfite oxidase | - |
Bacillus sp. (in: Bacteria) |
| sulfite oxidase | - |
Bacillus licheniformis |
| sulfite oxidase | - |
Chlorella vulgaris |
| sulfite oxidase | - |
Saccharopolyspora erythraea |
| sulfite oxidase | - |
Paenarthrobacter aurescens |
| sulfite oxidase | - |
Deinococcus radiodurans |
| sulfite oxidase | - |
Arabidopsis thaliana |
| sulfite oxidase | - |
Streptomyces ambofaciens |
| sulfite oxidase | - |
Erythrobacter litoralis |
| sulfite oxidase | - |
Rubrobacter xylanophilus |
| sulfite oxidase | - |
Rhizorhabdus wittichii RW1 |
| sulfite oxidase | - |
Maribacter sp. HTCC2170 |
| sulfite oxidase | - |
Roseovarius nubinhibens |
| sulfite oxidase | - |
Gallus gallus |
| SUOX | - |
Thermus thermophilus |
| SUOX | - |
Escherichia coli |
| SUOX | - |
Homo sapiens |
| SUOX | - |
Spinacia oleracea |
| SUOX | - |
Zea mays |
| SUOX | - |
Ogataea angusta |
| SUOX | - |
Bacillus sp. (in: Bacteria) |
| SUOX | - |
Bacillus licheniformis |
| SUOX | - |
Chlorella vulgaris |
| SUOX | - |
Saccharopolyspora erythraea |
| SUOX | - |
Paenarthrobacter aurescens |
| SUOX | - |
Deinococcus radiodurans |
| SUOX | - |
Arabidopsis thaliana |
| SUOX | - |
Streptomyces ambofaciens |
| SUOX | - |
Erythrobacter litoralis |
| SUOX | - |
Rubrobacter xylanophilus |
| SUOX | - |
Rhizorhabdus wittichii RW1 |
| SUOX | - |
Maribacter sp. HTCC2170 |
| SUOX | - |
Roseovarius nubinhibens |
| SUOX | - |
Gallus gallus |
| YedY | - |
Escherichia coli |
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