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Literature summary for 1.8.1.B1 extracted from

  • Kalita, P.; Shukla, H.; Das, K.C.; Tripathi, T.
    Conserved Arg451 residue is critical for maintaining the stability and activity of thioredoxin glutathione reductase (2019), Arch. Biochem. Biophys., 674, 108098 .
    View publication on PubMed
Search for more literature for 1.8.1.B1

Protein Variants

Protein Variants Comment Organism
R451A mutation mutation led to the decreased stability of the protein. Mutation significantly decreases both oxidoreductase activities (glutathione reductase and thioredoxin reductase) of the enzyme Fasciola gigantica

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
glutathione disulfide + NADPH + H+ Fasciola gigantica the enzyme plays an essential role in maintaining the redox homeostasis and antioxidant defenses in the parasite Fasciola gigantica. Parasitic flukes have a limited set of antioxidant proteins in contrast to their mammalian hosts. In platyhelminthic parasites, the two systems (glutathione/glutaredoxin system and thioredoxin system) are replaced by a single system of a multifunctional flavin containing chimeric selenoenzyme known as thioredoxin glutathione reductase, which donates electrons to both thioredoxin disulfide and glutathione disulfide in these parasites 2 glutathione + NADP+
-
 ?
thioredoxin disulfide + NADPH + H+ Fasciola gigantica
-
 thioredoxin + NADP+
-
 ?

Organism

Organism UniProt Comment Textmining
Fasciola gigantica
-
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
glutathione disulfide + NADPH + H+
-
 Fasciola gigantica 2 glutathione + NADP+
-
 ?
glutathione disulfide + NADPH + H+ the enzyme plays an essential role in maintaining the redox homeostasis and antioxidant defenses in the parasite Fasciola gigantica. Parasitic flukes have a limited set of antioxidant proteins in contrast to their mammalian hosts. In platyhelminthic parasites, the two systems (glutathione/glutaredoxin system and thioredoxin system) are replaced by a single system of a multifunctional flavin containing chimeric selenoenzyme known as thioredoxin glutathione reductase, which donates electrons to both thioredoxin disulfide and glutathione disulfide in these parasites Fasciola gigantica 2 glutathione + NADP+
-
 ?
thioredoxin disulfide + NADPH + H+
-
 Fasciola gigantica thioredoxin + NADP+
-
 ?

Synonyms

Synonyms Comment Organism
TGR
-
 Fasciola gigantica
thioredoxin glutathione reductase
-
 Fasciola gigantica

General Information

General Information Comment Organism
physiological function the enzyme plays an essential role in maintaining the redox homeostasis and antioxidant defenses in the parasite Fasciola gigantica. Parasitic flukes have a limited set of antioxidant proteins in contrast to their mammalian hosts. In platyhelminthic parasites, the two systems (glutathione/glutaredoxin system and thioredoxin system) are replaced by a single system of a multifunctional flavin containing chimeric selenoenzyme known as thioredoxin glutathione reductase, which donates electrons to both thioredoxin disulfide and glutathione disulfide in these parasites Fasciola gigantica