Cloned (Comment) | Organism |
---|---|
the ORF of Ov-TGR is inserted into pABC2 plasmid and transformed into Escherichia coli strain C321.DETLTAA to facilitate selenocysteine incorporation | Opisthorchis viverrini |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
auranofin | inhibition in a dose-dependent manner. The inhibitor expresses a lethal toxic effect on both newly excysted juveniles and adult worms of Opisthorchis viverrini in vitro | Opisthorchis viverrini |
KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
0.00809 | - |
glutathione disulfide | pH 7.4, 25°C | Opisthorchis viverrini | |
0.01374 | - |
thioredoxin disulfide | pH 7.4, 25°C | Opisthorchis viverrini |
Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
---|---|---|---|
66000 | - |
calculated from sequence | Opisthorchis viverrini |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
glutathione disulfide + NADPH + H+ | Opisthorchis viverrini | - |
2 glutathione + NADP+ | - |
? | |
thioredoxin disulfide + NADPH + H+ | Opisthorchis viverrini | - |
thioredoxin + NADP+ | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Opisthorchis viverrini | A0A6C0NKS2 | - |
- |
Purification (Comment) | Organism |
---|---|
- |
Opisthorchis viverrini |
Source Tissue | Comment | Organism | Textmining |
---|
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
glutathione disulfide + NADPH + H+ | - |
Opisthorchis viverrini | 2 glutathione + NADP+ | - |
? | |
thioredoxin disulfide + NADPH + H+ | - |
Opisthorchis viverrini | thioredoxin + NADP+ | - |
? |
Subunits | Comment | Organism |
---|---|---|
dimer | - |
Opisthorchis viverrini |
Synonyms | Comment | Organism |
---|---|---|
TGR | - |
Opisthorchis viverrini |
thioredoxin glutathione reductase | - |
Opisthorchis viverrini |
Turnover Number Minimum [1/s] | Turnover Number Maximum [1/s] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
8.79 | - |
thioredoxin disulfide | pH 7.4, 25°C | Opisthorchis viverrini | |
61.04 | - |
glutathione disulfide | pH 7.4, 25°C | Opisthorchis viverrini |
General Information | Comment | Organism |
---|---|---|
drug target | the enzyme maybe a potential target for the development of novel agents against opisthorschiasis | Opisthorchis viverrini |
physiological function | the enzyme is crucial for Opisthorchis viverrini survival | Opisthorchis viverrini |
kcat/KM Value [1/mMs-1] | kcat/KM Value Maximum [1/mMs-1] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
640 | - |
thioredoxin disulfide | pH 7.4, 25°C | Opisthorchis viverrini | |
7500 | - |
glutathione disulfide | pH 7.4, 25°C | Opisthorchis viverrini |