Literature summary for 1.8.1.B1 extracted from

Fata, F.; Silvestri, I.; Ardini, M.; Ippoliti, R.; Di Leandro, L.; Demitri, N.; Polentarutti, M.; Di Matteo, A.; Lyu, H.; Thatcher, G.R.J.; Petukhov, P.A.; Williams, D.L.; Angelucci, F.
Probing the surface of a parasite drug target thioredoxin glutathione reductase using small molecule fragments (2021), ACS Infect. Dis., 7, 1932-1944 .

Search for more literature for 1.8.1.B1

Crystallization (Commentary)

Crystallization (Comment)	Organism
sitting drop method	Schistosoma mansoni

Protein Variants

Protein Variants	Comment	Organism
E330A/D334A	mutation of two key residues interacting with the inhibitor 4-aminopiazthiole. Inhibition at 0.5 mM 4-aminopiazthiole is indistinguishable from that of the wild type enzyme	Schistosoma mansoni
E337A	mutation of E337 an interacting residue of the inhibitor indole-3-carbinol, Inhibition at 0.5 mM indole-3-carbinol is indistinguishable from that of the wild type enzyme	Schistosoma mansoni

Inhibitors

Inhibitors	Comment	Organism	Structure
4-aminopiazthiole	inhibit the enzyme in a NADPH-dependent manner, and the inhibition appears to be irreversible even upon extensive dilution of the inhibited protein	Schistosoma mansoni
indole-3-carbinol	inhibit the enzyme in a NADPH-dependent manner, and the inhibition appears to be irreversible even upon extensive dilution of the inhibited protein	Schistosoma mansoni

Organism

Organism	UniProt	Comment	Textmining
Schistosoma mansoni	A0A3Q0KFL1	-	-

Synonyms

Synonyms	Comment	Organism
TGR	-	Schistosoma mansoni
thioredoxin glutathione reductase	-	Schistosoma mansoni

Use of this online version of BRENDA is free under the CC BY 4.0 license. See terms of use for full details.

Release 2023.1 (January 2023)