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Literature summary for 1.8.1.9 extracted from
- Investigation of the effects of purification and characterization of turkey (Meleagris gallopavo) liver mitochondrial thioredoxin reductase enzyme and some metal ions on enzyme activity (2017), Turk. J. Chem., 41, 48-60 .
No PubMed abstract available
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| Ag+ | noncompetitive | Meleagris gallopavo |  |
| Cd2+ | noncompetitive | Meleagris gallopavo | |
| Cu2+ | competitive | Meleagris gallopavo | |
| Fe3+ | competitive | Meleagris gallopavo | |
| Zn2+ | noncompetitive | Meleagris gallopavo | |
KM Value [mM]
| KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
|---|---|---|---|---|---|
| 0.0014 | - |
NADPH | pH 7.5, 50°C | Meleagris gallopavo | |
| 0.032 | - |
5,5'-dithio-bis(2-nitrobenzoic acid) | pH 7.5, 50°C | Meleagris gallopavo | |
Metals/Ions
| Metals/Ions | Comment | Organism | Structure |
|---|---|---|---|
| Pb2+ | 10 mM, 220% of initial activity | Meleagris gallopavo | |
Molecular Weight [Da]
| Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
|---|---|---|---|
| 88000 | - |
gel fitlration | Meleagris gallopavo |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Meleagris gallopavo | - |
- |
- |
Purification (Commentary)
| Purification (Comment) | Organism |
|---|---|
| purification from liver | Meleagris gallopavo |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| liver | - |
Meleagris gallopavo | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| 5,5'-dithio-bis(2-nitrobenzoic acid) + NADPH + H+ | - |
Meleagris gallopavo | 5'-thionitrobenzoic acid + NADP+ | - |
? | |
Subunits
| Subunits | Comment | Organism |
|---|---|---|
| dimer | 2 * 45500, SDS-PAGE | Meleagris gallopavo |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| TrxR | - |
Meleagris gallopavo |
Temperature Optimum [°C]
| Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
|---|---|---|---|
| 50 | - |
- |
Meleagris gallopavo |
Turnover Number [1/s]
| Turnover Number Minimum [1/s] | Turnover Number Maximum [1/s] | Substrate | Comment | Organism | Structure |
|---|---|---|---|---|---|
| 87.8 | - |
5,5'-dithio-bis(2-nitrobenzoic acid) | pH 7.5, 50°C | Meleagris gallopavo | |
| 109.8 | - |
NADPH | pH 7.5, 50°C | Meleagris gallopavo | |
pH Optimum
| pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
|---|---|---|---|
| 7.5 | - |
600 mM potassium phosphate buffer | Meleagris gallopavo |
Cofactor
| Cofactor | Comment | Organism | Structure |
|---|---|---|---|
| NADPH | - |
Meleagris gallopavo | |
IC50 Value
| IC50 Value | IC50 Value Maximum | Comment | Organism | Inhibitor | Structure |
|---|---|---|---|---|---|
| 0.019 | - |
pH 7.5, 50°C | Meleagris gallopavo | Ag+ | |
| 0.529 | - |
pH 7.5, 50°C | Meleagris gallopavo | Cd2+ | |
| 0.61 | - |
pH 7.5, 50°C | Meleagris gallopavo | Fe3+ | |
| 1.46 | - |
pH 7.5, 50°C | Meleagris gallopavo | Cu2+ | |
| 3.4 | - |
pH 7.5, 50°C | Meleagris gallopavo | Zn2+ | |
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