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Literature summary for 1.8.1.9 extracted from

  • de Freitas, A.S.; Rocha, J.B.
    Diphenyl diselenide and analogs are substrates of cerebral rat thioredoxin reductase: a pathway for their neuroprotective effects (2011), Neurosci. Lett., 503, 1-5.
    View publication on PubMed

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
thioredoxin disulfide + NADPH + H+ Rattus norvegicus
-
thioredoxin + NADP+
-
?

Organism

Organism UniProt Comment Textmining
Rattus norvegicus
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
brain
-
Rattus norvegicus
-
cerebrum
-
Rattus norvegicus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
4,4'-bischloro-diphenyl diselenide + NADPH + H+
-
Rattus norvegicus ?
-
?
4,4'-bismethoxy-diphenyl diselenide + NADPH + H+
-
Rattus norvegicus ?
-
?
diphenyl diselenide + NADPH + H+
-
Rattus norvegicus ?
-
?
additional information ebselen, 4,4'-bistrifluoromethyl-diphenyl diselenide, 2,4,6,2',4',6‘-hexamethyldiphenyl diselenide, and 4,4'-biscarboxydiphenyl diselenide are no substrates Rattus norvegicus ?
-
?
thioredoxin disulfide + NADPH + H+
-
Rattus norvegicus thioredoxin + NADP+
-
?

Synonyms

Synonyms Comment Organism
TrxR
-
Rattus norvegicus

Cofactor

Cofactor Comment Organism Structure
NADPH
-
Rattus norvegicus