Application | Comment | Organism |
---|---|---|
medicine | inhibition of thioredoxin reductase represents a potential target in pancreatic cancer and provides a biomarker of effect of lead indolequinones in this type of cancer | Homo sapiens |
medicine | inhibition of thioredoxin reductase represents a potential target in pancreatic cancer and provides a biomarker of effect of lead indolequinones in this type of cancer | Rattus norvegicus |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
2-hydroxymethyl-5-methoxy-1-methyl-3-[(2,4,6-trifluorophenoxy)methyl]indole-4,7-dione | maximum inhibition is achieved 5 min after addition of 0.003 mM | Homo sapiens | |
2-hydroxymethyl-5-methoxy-1-methyl-3-[(2,4,6-trifluorophenoxy)methyl]indole-4,7-dione | maximum inhibition is achieved 5 min after addition of 0.003 mM | Rattus norvegicus | |
2-hydroxymethyl-5-methoxy-1-methyl-3-[(4-nitrophenoxy)methyl]indole-4,7-dione | - |
Homo sapiens | |
2-hydroxymethyl-5-methoxy-1-methyl-3-[(4-nitrophenoxy)methyl]indole-4,7-dione | - |
Rattus norvegicus | |
2-hydroxymethyl-6-methoxy-1-methyl-3-[(4-nitrophenoxy)methyl]indole-4,7-dione | - |
Homo sapiens | |
2-hydroxymethyl-6-methoxy-1-methyl-3-[(4-nitrophenoxy)methyl]indole-4,7-dione | - |
Rattus norvegicus | |
5-methoxy-1,2-dimethyl-3-[1-oxo-2-(2,4,6-trifluorophenyl)ethyl]indole-4,7-dione | - |
Homo sapiens | |
5-methoxy-1,2-dimethyl-3-[1-oxo-2-(2,4,6-trifluorophenyl)ethyl]indole-4,7-dione | - |
Rattus norvegicus | |
5-methoxy-1-methyl-3-[(2,4,6-trifluorophenoxy)methyl]indole-4,7-dione | - |
Homo sapiens | |
5-methoxy-1-methyl-3-[(2,4,6-trifluorophenoxy)methyl]indole-4,7-dione | - |
Rattus norvegicus | |
5-methoxy-1-methyl-3-[(4-nitrophenoxy)methyl]indole-4,7-dione | - |
Homo sapiens | |
5-methoxy-1-methyl-3-[(4-nitrophenoxy)methyl]indole-4,7-dione | - |
Rattus norvegicus | |
6-methoxy-1-methyl-3-[(2,4,6-trifluorophenoxy)methyl]indole-4,7-dione | - |
Homo sapiens | |
6-methoxy-1-methyl-3-[(2,4,6-trifluorophenoxy)methyl]indole-4,7-dione | - |
Rattus norvegicus | |
6-methoxy-1-methyl-3-[(4-nitrophenoxy)methyl]indole-4,7-dione | - |
Homo sapiens | |
6-methoxy-1-methyl-3-[(4-nitrophenoxy)methyl]indole-4,7-dione | - |
Rattus norvegicus | |
ES936 | i.e. 5-methoxy-1,2-dimethyl-3-[(4-nitrophenoxy)methyl]indole-4,7-dione, potent inhibitor | Homo sapiens | |
ES936 | i.e. 5-methoxy-1,2-dimethyl-3-[(4-nitrophenoxy)methyl]indole-4,7-dione, potent inhibitor | Rattus norvegicus |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Rattus norvegicus | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
BxPC-3 cell | - |
Homo sapiens | - |
MiaPaCa-2 cell | - |
Homo sapiens | - |
additional information | NCI-60 cell panel | Homo sapiens | - |
PANC-1 cell | - |
Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
5,5'-dithiobis(2-nitrobenzoic acid) + NADPH + H+ | - |
Homo sapiens | 2-nitro-5-thiobenzoate + NADP+ | - |
? | |
5,5'-dithiobis(2-nitrobenzoic acid) + NADPH + H+ | - |
Rattus norvegicus | 2-nitro-5-thiobenzoate + NADP+ | - |
? |
Synonyms | Comment | Organism |
---|---|---|
thioredoxin reductase | - |
Homo sapiens |
thioredoxin reductase | - |
Rattus norvegicus |
TrxR | - |
Homo sapiens |
TrxR | - |
Rattus norvegicus |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
NADPH | - |
Homo sapiens | |
NADPH | - |
Rattus norvegicus |
IC50 Value | IC50 Value Maximum | Comment | Organism | Inhibitor | Structure |
---|---|---|---|---|---|
0.000082 | - |
in 100 mM potassium phosphate buffer, pH 7.4, at 22°C | Rattus norvegicus | 5-methoxy-1,2-dimethyl-3-[1-oxo-2-(2,4,6-trifluorophenyl)ethyl]indole-4,7-dione | |
0.000146 | - |
in 100 mM potassium phosphate buffer, pH 7.4, at 22°C | Rattus norvegicus | 2-hydroxymethyl-5-methoxy-1-methyl-3-[(2,4,6-trifluorophenoxy)methyl]indole-4,7-dione |