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Literature summary for 1.8.1.9 extracted from

  • Rigobello, M.P.; Bindoli, A.
    Mitochondrial thioredoxin reductase purification, inhibitor studies, and role in cell signaling (2010), Methods Enzymol., 474, 109-122.
    View publication on PubMed

Localization

Localization Comment Organism GeneOntology No. Textmining
mitochondrion
-
Rattus norvegicus 5739
-

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
54000
-
about 54000 Da, SDS-PAGE Rattus norvegicus

Organism

Organism UniProt Comment Textmining
Rattus norvegicus
-
-
-

Purification (Commentary)

Purification (Comment) Organism
ammonium sulfate precipitation, DEAE-Sephacel gel filtration, 2',5'-ADP-Sepharose 4B affinity chromatography, and omega-aminohexyl-Sepharose 4B column chromatography Rattus norvegicus

Source Tissue

Source Tissue Comment Organism Textmining
brain
-
Rattus norvegicus
-
heart
-
Rattus norvegicus
-
kidney
-
Rattus norvegicus
-
liver
-
Rattus norvegicus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
5,5'-dithiobis(2-nitrobenzoic acid) + NADPH + H+
-
Rattus norvegicus 2-nitro-5-thiobenzoate + NADP+
-
?
alloxan + NADPH + H+
-
Rattus norvegicus ? + NADP+
-
?
selenite + NADPH + H+
-
Rattus norvegicus ? + NADP+
-
?
thioredoxin disulfide + NADPH + H+
-
Rattus norvegicus thioredoxin + NADP+
-
?

Synonyms

Synonyms Comment Organism
thioredoxin reductase
-
Rattus norvegicus
TrxR2 also called TR3 or TRbeta Rattus norvegicus

Cofactor

Cofactor Comment Organism Structure
FAD
-
Rattus norvegicus
NADPH
-
Rattus norvegicus

General Information

General Information Comment Organism
malfunction inhibition of mitochondrial thioredoxin reductase leads to oxidation of downstream enzymes such as thioredoxin and peroxiredoxin Rattus norvegicus