Cloned (Comment) | Organism |
---|---|
expressed in Escherichia coli | Homo sapiens |
Crystallization (Comment) | Organism |
---|---|
in complex with FAD, NADPH and/or (N-acetyl-4-aminothiophenolato)(2,2':6',2''-terpyridine)platinum(II) chloride, sitting drop vapor diffusion method, using 5 mM MgSO4, 5% (w/v) PEG 3350, 50 mM MES pH 6.0 and 20% (w/v) 1,6-hexanediol | Homo sapiens |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
(4-ammoniothiophenolato)(2,2':6',2''-terpyridine)platinum(II) chloride | - |
Homo sapiens | |
(4-ammoniothiophenolato)(4'-toyl-2,2':6',2''-terpyridine)platinum(II) nitrate | - |
Homo sapiens | |
(4-hydroxylthiophenolato)(2,2':6',2''-terpyridine)platinum(II) chloride | - |
Homo sapiens | |
(4-hydroxylthiophenolato)(4'-toyl-2,2':6',2''-terpyridine)platinum(II) chloride | - |
Homo sapiens | |
(N-acetyl-4-aminothiophenolato)(2,2':6',2''-terpyridine)platinum(II) chloride | - |
Homo sapiens | |
(N-acetyl-4-aminothiophenolato)(4'-toyl-2,2':6',2''-terpyridine)platinum(II) nitrate | - |
Homo sapiens | |
cisplatin | - |
Homo sapiens |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | Q16881 | - |
- |
Purification (Comment) | Organism |
---|---|
Ni2+ affinity column chromatography | Homo sapiens |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
HeLa cell | - |
Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
5,5'-dithiobis(2-nitrobenzoic acid) + NADPH + H+ | - |
Homo sapiens | 2-nitro-5-thiobenzoate + NADP+ | - |
? |
Synonyms | Comment | Organism |
---|---|---|
thioredoxin reductase 1 | - |
Homo sapiens |
TrxR1 | - |
Homo sapiens |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
FAD | - |
Homo sapiens | |
NADPH | - |
Homo sapiens |
IC50 Value | IC50 Value Maximum | Comment | Organism | Inhibitor | Structure |
---|---|---|---|---|---|
0.00005826 | - |
in 50 mM Tris-HCl, pH 8.0, at 37°C | Homo sapiens | (4-hydroxylthiophenolato)(4'-toyl-2,2':6',2''-terpyridine)platinum(II) chloride | |
0.00006977 | - |
in 50 mM Tris-HCl, pH 8.0, at 37°C | Homo sapiens | (4-hydroxylthiophenolato)(2,2':6',2''-terpyridine)platinum(II) chloride | |
0.00007002 | - |
in 50 mM Tris-HCl, pH 8.0, at 37°C | Homo sapiens | (4-ammoniothiophenolato)(4'-toyl-2,2':6',2''-terpyridine)platinum(II) nitrate | |
0.00007426 | - |
in 50 mM Tris-HCl, pH 8.0, at 37°C | Homo sapiens | (N-acetyl-4-aminothiophenolato)(2,2':6',2''-terpyridine)platinum(II) chloride | |
0.00007442 | - |
in 50 mM Tris-HCl, pH 8.0, at 37°C | Homo sapiens | (4-ammoniothiophenolato)(2,2':6',2''-terpyridine)platinum(II) chloride | |
0.00007786 | - |
in 50 mM Tris-HCl, pH 8.0, at 37°C | Homo sapiens | (N-acetyl-4-aminothiophenolato)(4'-toyl-2,2':6',2''-terpyridine)platinum(II) nitrate |