Any feedback?
Literature summary for 1.8.1.9 extracted from
- Thioredoxin reductase 1 upregulates MCP-1 release in human endothelial cells (2009), Biochem. Biophys. Res. Commun., 386, 703-708.
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| thioredoxin disulfide + NADPH + H+ | Homo sapiens | - |
thioredoxin + NADP+ | - |
? |  |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Homo sapiens | - |
- |
- |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| EAhy926 cell | - |
Homo sapiens | - |
| endothelial cell | - |
Homo sapiens | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| thioredoxin disulfide + NADPH + H+ | - |
Homo sapiens | thioredoxin + NADP+ | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| thioredoxin reductase 1 | - |
Homo sapiens |
| TrxR1 | - |
Homo sapiens |
Cofactor
| Cofactor | Comment | Organism | Structure |
|---|---|---|---|
| NADPH | - |
Homo sapiens | |
General Information
| General Information | Comment | Organism |
|---|---|---|
| physiological function | thioredoxin reductase 1 overexpression upregulates monocyte chemoattractant protein-1 release in human endothelial cells by 34%. TrxR1 enhances reactive oxygen species generation, NF-kappaB activity and subsequent monocyte chemoattractant protein-1 expression in endothelial cells, and may promote rather than prevent vascular endothelium from forming atherosclerotic plaque | Homo sapiens |
Use of this online version of BRENDA is free under the CC BY 4.0 license. See terms of use for full details.
Release 2023.1 (January 2023)
Legal
Curated at
Member of
