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Literature summary for 1.8.1.9 extracted from
- Focus on mammalian thioredoxin reductases--important selenoproteins with versatile functions (2009), Biochim. Biophys. Acta, 1790, 495-526.
Metals/Ions
| Metals/Ions | Comment | Organism | Structure |
|---|---|---|---|
| selenium | thioredoxin reductase is a selenoprotein | Homo sapiens |  |
| selenium | thioredoxin reductase is a selenoprotein | Mus musculus | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Homo sapiens | - |
- |
- |
| Mus musculus | Q9JLT4 | - |
- |
| Mus musculus | Q9JMH6 | - |
- |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| embryo | - |
Mus musculus | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| thioredoxin disulfide + NADPH + H+ | - |
Homo sapiens | thioredoxin + NADP+ | - |
? | |
| thioredoxin disulfide + NADPH + H+ | - |
Mus musculus | thioredoxin + NADP+ | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| thioredoxin reductase | - |
Homo sapiens |
| thioredoxin reductase | - |
Mus musculus |
| Txnrd1 | isozyme | Homo sapiens |
| Txnrd1 | isoform | Mus musculus |
| Txnrd2 | isozyme | Homo sapiens |
| Txnrd2 | isoform | Mus musculus |
| TXNRD3 | isozyme | Homo sapiens |
Cofactor
| Cofactor | Comment | Organism | Structure |
|---|---|---|---|
| NADPH | - |
Homo sapiens | |
| NADPH | - |
Mus musculus | |
General Information
| General Information | Comment | Organism |
|---|---|---|
| physiological function | Txnrd1 gene is essential for normal development during embryogenesis | Mus musculus |
| physiological function | Txnrd2 gene is essential for normal development during embryogenesis | Mus musculus |
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Release 2023.1 (January 2023)
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