Inhibitors | Comment | Organism | Structure |
---|---|---|---|
trans,trans-curcumin | 0.01-0.05 mM, IC50: 0.0015 mM, irreversible inhibition | Homo sapiens | |
trans,trans-curcumin | IC50: 0.0036 mM, irreversible inhibition after incubation at room temperature for 2 h in vitro | Rattus norvegicus |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
cytosol | TrxR1 | Homo sapiens | 5829 | - |
cytosol | TrxR1 | Rattus norvegicus | 5829 | - |
mitochondrion | TrxR2 | Homo sapiens | 5739 | - |
mitochondrion | TrxR2 | Rattus norvegicus | 5739 | - |
nucleus | TrxR1 | Homo sapiens | 5634 | - |
nucleus | TrxR1 | Rattus norvegicus | 5634 | - |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Rattus norvegicus | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
HeLa cell | - |
Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
thioredoxin + NADP+ | - |
Homo sapiens | thioredoxin disulfide + NADPH | - |
? | |
thioredoxin + NADP+ | - |
Rattus norvegicus | thioredoxin disulfide + NADPH | - |
? |
Synonyms | Comment | Organism |
---|---|---|
thioredoxin reductase | - |
Homo sapiens |
thioredoxin reductase | - |
Rattus norvegicus |
TrxR | - |
Homo sapiens |
TrxR | - |
Rattus norvegicus |
TrxR1 | - |
Homo sapiens |
TrxR1 | - |
Rattus norvegicus |
TrxR2 | - |
Homo sapiens |
TrxR2 | - |
Rattus norvegicus |
IC50 Value | IC50 Value Maximum | Comment | Organism | Inhibitor | Structure |
---|---|---|---|---|---|
0.0015 | - |
0.01-0.05 mM, IC50: 0.0015 mM, irreversible inhibition | Homo sapiens | trans,trans-curcumin | |
0.0036 | - |
IC50: 0.0036 mM, irreversible inhibition after incubation at room temperature for 2 h in vitro | Rattus norvegicus | trans,trans-curcumin |