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Literature summary for 1.8.1.9 extracted from

  • Liu, S.Y.; Stadtman, T.
    Heparin-binding properties of selenium-containing thioredoxin reductase from HeLa cells and human lung adenocarcinoma cells (1997), Proc. Natl. Acad. Sci. USA, 94, 6138-6141.
    View publication on PubMedView publication on EuropePMC

Activating Compound

Activating Compound Comment Organism Structure
cysteine part of the active site Homo sapiens

Metals/Ions

Metals/Ions Comment Organism Structure
selenocysteine contains selenocysteine as part of the redox active selenosulfide in the active center Homo sapiens

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
57000
-
2 * 57000, SDS-PAGE Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
HeLa cells
-

Source Tissue

Source Tissue Comment Organism Textmining
HeLa cell high and low affinity form with respect to heparin Homo sapiens
-
lung adenocarcinoma cells, high and low affinity form with respect to heparin Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
5,5'-dithiobis(2-nitrobenzoic acid) + NADPH i.e. DTNB Homo sapiens 2-nitro-5-thiobenzoate + NADP+
-
?
5,5'-dithiobis(2-nitrobenzoic acid) + NADPH coupled assay Homo sapiens 2-nitro-5-thiobenzoate + NADP+
-
?
thioredoxin + NADP+ coupled assay with DTNB Homo sapiens thioredoxin disulfide + NADPH
-
?
thioredoxin + NADP+ coupled assay, measurement of NADPH oxidation in presence of insulin and thioredoxin Homo sapiens thioredoxin disulfide + NADPH
-
?
thioredoxin + NADP+ in presence of NADPH, coupled assay Homo sapiens thioredoxin disulfide + NADPH + H+
-
?

Subunits

Subunits Comment Organism
dimer 2 * 57000, SDS-PAGE Homo sapiens

Cofactor

Cofactor Comment Organism Structure
FAD
-
Homo sapiens
NADPH
-
Homo sapiens