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Literature summary for 1.8.1.7 extracted from

  • Dalmizrak, O.; Terali, K.; Abdullah, R.K.; Ozer, N.
    Mechanistic and structural insights into the in vitro inhibitory action of hypericin on glutathione reductase purified from bakers yeast (2018), J. Biochem. Mol. Toxicol., 32, e22051 .
    View publication on PubMed
Search for more literature for 1.8.1.7

Inhibitors

Inhibitors Comment Organism Structure
hypericin when is glutathione disulfide is the variable substrate, hypericin inhibits the enzyme competitively Saccharomyces cerevisiae

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
glutathione disulfide + NADPH + H+ Saccharomyces cerevisiae
-
 2 glutathione + NADP+
-
 ?
glutathione disulfide + NADPH + H+ Saccharomyces cerevisiae ATCC 204508
-
 2 glutathione + NADP+
-
 ?

Organism

Organism UniProt Comment Textmining
Saccharomyces cerevisiae P41921
-
-
Saccharomyces cerevisiae ATCC 204508 P41921
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
glutathione disulfide + NADPH + H+
-
 Saccharomyces cerevisiae 2 glutathione + NADP+
-
 ?
glutathione disulfide + NADPH + H+
-
 Saccharomyces cerevisiae ATCC 204508 2 glutathione + NADP+
-
 ?

Synonyms

Synonyms Comment Organism
glutathione reductase
-
 Saccharomyces cerevisiae

Ki Value [mM]

Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
0.00292
-
 hypericin pH 7.5, 37°C Saccharomyces cerevisiae

IC50 Value

IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
0.0185
-
 pH 7.5, 37°C Saccharomyces cerevisiae hypericin