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Literature summary for 1.8.1.7 extracted from

  • VuThi, H.; Jang, S.H.; Lee, C.
    Cloning and characterization of a thermostable glutathione reductase from a psychrophilic Arctic bacterium Sphingomonas sp. (2019), FEMS Microbiol. Lett., 366, fnz218 .
    View publication on PubMed
Search for more literature for 1.8.1.7

Cloned(Commentary)

Cloned (Comment) Organism
expression in Escherichia coli BL21 (DE) Sphingomonas sp.

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
glutathione disulfide + NADPH + H+ Sphingomonas sp. the enzyme is an important oxidoreductase that helps maintain redox homeostasis 2 glutathione + NADP+
-
 ?

Organism

Organism UniProt Comment Textmining
Sphingomonas sp. WP_010214957
-
-

Purification (Commentary)

Purification (Comment) Organism
-
 Sphingomonas sp.

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
glutathione disulfide + NADPH + H+
-
 Sphingomonas sp. 2 glutathione + NADP+
-
 ?
glutathione disulfide + NADPH + H+ the enzyme is an important oxidoreductase that helps maintain redox homeostasis Sphingomonas sp. 2 glutathione + NADP+
-
 ?

Subunits

Subunits Comment Organism
dimer
-
 Sphingomonas sp.

Synonyms

Synonyms Comment Organism
glutathione reductase
-
 Sphingomonas sp.
SpGR
-
 Sphingomonas sp.

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
60
-
-
 Sphingomonas sp.

Temperature Range [°C]

Temperature Minimum [°C] Temperature Maximum [°C] Comment Organism
30 70 30°C: about 50% of maximal activity, 70°C: about 85% of maximal activity Sphingomonas sp.

Temperature Stability [°C]

Temperature Stability Minimum [°C] Temperature Stability Maximum [°C] Comment Organism
50
-
 2 h, 50% residual activity Sphingomonas sp.

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
7.5
-
-
 Sphingomonas sp.

pH Range

pH Minimum pH Maximum Comment Organism
6.5 8 pH 6.5: about 50% of maximal activity, pH 8.0: about 55% of maximal activity Sphingomonas sp.

General Information

General Information Comment Organism
physiological function the enzyme is an important oxidoreductase that helps maintain redox homeostasis. It possesses the characteristics of thermophilic enzymes and functions at colder temperatures, thereby maintaining the reducing power of the Arctic bacterium Sphingomonas sp. PAMC 26621 in a broad range of temperatures Sphingomonas sp.