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Literature summary for 1.8.1.7 extracted from
- The glutathione reductase GSR-1 determines stress tolerance and longevity in Caenorhabditis elegans (2013), PLoS ONE, 8, e60731 .
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Caenorhabditis elegans | Q93379 | - |
- |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| GSR-1 | - |
Caenorhabditis elegans |
General Information
| General Information | Comment | Organism |
|---|---|---|
| physiological function | glutathione reductase GSR-1 is essential for survival under juglone stress conditions. Knockdown of GSR-1 hardly affects total glutathione levels nor reduced glutathione/glutathione disulfide (GSH/GSSG) ratio under normal laboratory conditions. When GSSG recycling is impaired by RNAi, GSH synthesis is induced, but not vice versa. The impact of GSSG recycling is potentiated under oxidative stress conditions. Ovepression of GSR-1 is capable of increasing stress tolerance. Expression levels of GSR-1 also affect life span of Caenorhabditis elegans | Caenorhabditis elegans |
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