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Literature summary for 1.8.1.7 extracted from

  • Plancarte, A.; Nava, G.; Munguia, J.A.
    A new thioredoxin reductase with additional glutathione reductase activity in Haemonchus contortus (2017), Exp. Parasitol., 177, 82-92 .
    View publication on PubMed

Inhibitors

Inhibitors Comment Organism Structure
NADP+ competitive Haemonchus contortus
Zn2+ 2 mM, complete inhibition Haemonchus contortus

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.089
-
glutathione disulfide pH 7.8, 37°C Haemonchus contortus

Metals/Ions

Metals/Ions Comment Organism Structure
additional information Ba2+, Mn2+, and Mg2+ in a range of 0.01-5 mM have no effect on TrxR3 activity Haemonchus contortus

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
134000
-
gel filtration Haemonchus contortus

Organism

Organism UniProt Comment Textmining
Haemonchus contortus CDJ91018 thioredoxin reductase, EC 1.8.1.9, with additional glutathione reductase activity
-

Purification (Commentary)

Purification (Comment) Organism
-
Haemonchus contortus

Specific Activity [micromol/min/mg]

Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
0.118
-
pH 7.8, 37°C Haemonchus contortus

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
glutathione disulfide + NADPH + H+
-
Haemonchus contortus 2 glutathione + NADP+
-
?

Subunits

Subunits Comment Organism
dimer 2 * 67000, SDS-PAGE Haemonchus contortus

Synonyms

Synonyms Comment Organism
HCOI_01258400
-
Haemonchus contortus
TrxR3
-
Haemonchus contortus

Temperature Stability [°C]

Temperature Stability Minimum [°C] Temperature Stability Maximum [°C] Comment Organism
37
-
stable for 20 min Haemonchus contortus

Turnover Number [1/s]

Turnover Number Minimum [1/s] Turnover Number Maximum [1/s] Substrate Comment Organism Structure
2.95
-
glutathione disulfide pH 7.8, 37°C Haemonchus contortus

Cofactor

Cofactor Comment Organism Structure
NADPH
-
Haemonchus contortus

IC50 Value

IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
0.92
-
pH 7.8, 37°C Haemonchus contortus Zn2+

kcat/KM [mM/s]

kcat/KM Value [1/mMs-1] kcat/KM Value Maximum [1/mMs-1] Substrate Comment Organism Structure
2.95
-
glutathione disulfide pH 7.8, 37°C Haemonchus contortus