Inhibitors | Comment | Organism | Structure |
---|---|---|---|
(1R(S),2R(S),3S(R),4S(R))-2,3-dihydroxycyclo-hexane-1,4-diyl dinitrate | non-competitive inhibition | Homo sapiens | |
(1R(S),2R(S),4R(S),5R(S))-2,5-dihydroxycyclo-hexane-1,4-diyl dinitrate | non-competitive inhibition | Homo sapiens | |
(1S(R),2S(R),5R(S),6R(S))-5-bromo-9-oxabicyclo[4.2.1] nonan-2-yl nitrate | non-competitive inhibition | Homo sapiens | |
(1S(R),3S(R),4S(R),6S(R))-4,6-dihydroxycyclo-hexane-1,3-diyl dinitrate | non-competitive inhibition | Homo sapiens | |
(2R(S),7R(S))-7-hydroxybicyclo[2.2.1]heptan-2-yl nitrate | non-competitive inhibition | Homo sapiens | |
(2S(R),7R(S))-7-hydroxybicyclo[2.2.1] heptan-2-yl nitrate | non-competitive inhibition | Homo sapiens | |
(9R(S))-hydroxy-1,2,3,4-tetrahydro-1,4-methano-naphthalen-2R(S)-yl nitrate | non-competitive inhibition | Homo sapiens | |
trans-(1S(R),2S(R))-2-hydroxycyclohexyl nitrate | non-competitive inhibition | Homo sapiens | |
trans-(1S(R),2S(R))-2-hydroxycyclooctyl nitrate | non-competitive inhibition | Homo sapiens | |
trans-(1S(R),6S(R))-6-hydroxycyclohex-3-enyl nitrate | non-competitive inhibition | Homo sapiens | |
trans-(1S(R),8S(R),Z)-8-hydroxycyclooct-4-enyl nitrate | non-competitive inhibition | Homo sapiens | |
trans-(R(S))-2-hydroxy-1-phenylethyl nitrate | non-competitive inhibition | Homo sapiens |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
erythrocyte | - |
Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
glutathione disulfide + NADPH + H+ | - |
Homo sapiens | glutathione + NADP+ | - |
? |
Synonyms | Comment | Organism |
---|---|---|
EC 1.6.4.2 | formerly | Homo sapiens |
glutathione reductase | - |
Homo sapiens |
NADPH: oxidized glutathione oxidoreductase | - |
Homo sapiens |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
FAD | - |
Homo sapiens | |
NADPH | - |
Homo sapiens |
Ki Value [mM] | Ki Value maximum [mM] | Inhibitor | Comment | Organism | Structure |
---|---|---|---|---|---|
0.0117 | - |
(2R(S),7R(S))-7-hydroxybicyclo[2.2.1]heptan-2-yl nitrate | - |
Homo sapiens | |
0.0131 | - |
(2S(R),7R(S))-7-hydroxybicyclo[2.2.1] heptan-2-yl nitrate | - |
Homo sapiens | |
0.0174 | - |
(1R(S),2R(S),3S(R),4S(R))-2,3-dihydroxycyclo-hexane-1,4-diyl dinitrate | - |
Homo sapiens | |
0.0179 | - |
(1S(R),3S(R),4S(R),6S(R))-4,6-dihydroxycyclo-hexane-1,3-diyl dinitrate | - |
Homo sapiens | |
0.0184 | - |
(1R(S),2R(S),4R(S),5R(S))-2,5-dihydroxycyclo-hexane-1,4-diyl dinitrate | - |
Homo sapiens | |
0.0188 | - |
(9R(S))-hydroxy-1,2,3,4-tetrahydro-1,4-methano-naphthalen-2R(S)-yl nitrate | - |
Homo sapiens | |
0.0215 | - |
(1S(R),2S(R),5R(S),6R(S))-5-bromo-9-oxabicyclo[4.2.1] nonan-2-yl nitrate | - |
Homo sapiens | |
0.0219 | - |
trans-(1S(R),2S(R))-2-hydroxycyclooctyl nitrate | - |
Homo sapiens | |
0.0256 | - |
trans-(R(S))-2-hydroxy-1-phenylethyl nitrate | - |
Homo sapiens | |
0.0351 | - |
trans-(1S(R),6S(R))-6-hydroxycyclohex-3-enyl nitrate | - |
Homo sapiens | |
0.0437 | - |
trans-(1S(R),2S(R))-2-hydroxycyclohexyl nitrate | - |
Homo sapiens | |
0.0443 | - |
trans-(1S(R),8S(R),Z)-8-hydroxycyclooct-4-enyl nitrate | - |
Homo sapiens |
IC50 Value | IC50 Value Maximum | Comment | Organism | Inhibitor | Structure |
---|---|---|---|---|---|
0.00681 | - |
- |
Homo sapiens | (2R(S),7R(S))-7-hydroxybicyclo[2.2.1]heptan-2-yl nitrate | |
0.00713 | - |
- |
Homo sapiens | (2S(R),7R(S))-7-hydroxybicyclo[2.2.1] heptan-2-yl nitrate | |
0.00717 | - |
- |
Homo sapiens | (1R(S),2R(S),3S(R),4S(R))-2,3-dihydroxycyclo-hexane-1,4-diyl dinitrate | |
0.0081 | - |
- |
Homo sapiens | (1S(R),3S(R),4S(R),6S(R))-4,6-dihydroxycyclo-hexane-1,3-diyl dinitrate | |
0.00871 | - |
- |
Homo sapiens | (1R(S),2R(S),4R(S),5R(S))-2,5-dihydroxycyclo-hexane-1,4-diyl dinitrate | |
0.0103 | - |
- |
Homo sapiens | (9R(S))-hydroxy-1,2,3,4-tetrahydro-1,4-methano-naphthalen-2R(S)-yl nitrate | |
0.011 | - |
- |
Homo sapiens | (1S(R),2S(R),5R(S),6R(S))-5-bromo-9-oxabicyclo[4.2.1] nonan-2-yl nitrate | |
0.0142 | - |
- |
Homo sapiens | trans-(1S(R),2S(R))-2-hydroxycyclooctyl nitrate | |
0.016 | - |
- |
Homo sapiens | trans-(R(S))-2-hydroxy-1-phenylethyl nitrate | |
0.021 | - |
- |
Homo sapiens | trans-(1S(R),2S(R))-2-hydroxycyclohexyl nitrate | |
0.023 | - |
- |
Homo sapiens | trans-(1S(R),6S(R))-6-hydroxycyclohex-3-enyl nitrate | |
0.029 | - |
- |
Homo sapiens | trans-(1S(R),8S(R),Z)-8-hydroxycyclooct-4-enyl nitrate |