Literature summary for 1.8.1.7 extracted from

Deponte, M.; Urig, S.; Arscott, L.D.; Fritz-Wolf, K.; Reau, R.; Herold-Mende, C.; Koncarevic, S.; Meyer, M.; Davioud-Charvet, E.; Ballou, D.P.; Williams, C.H.; Becker, K.
Mechanistic studies on a novel, highly potent gold-phosphole inhibitor of human glutathione reductase (2005), J. Biol. Chem., 280, 20628-20637.

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Inhibitors

Inhibitors	Comment	Organism	Structure
[{1-phenyl-2,5-di(2-pyridyl)phosphole}AuCl]	gold-phosphole inhibitor, 1 nM, 50% inhibition, reversible	Homo sapiens

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	-	-	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
glutathione disulfide + NADPH + H+	-	Homo sapiens	glutathione + NADP+	-	?

Synonyms

Synonyms	Comment	Organism
glutathione reductase	-	Homo sapiens
GR	-	Homo sapiens
NADPH-reduced GR	-	Homo sapiens

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Release 2023.1 (January 2023)