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show all sequences of 1.8.1.7

Glutathione reductase

Schirmer, R.H.; Krauth-Siegel, R.L.; Schulz, G.E.; Coenzymes and cofactors, Glutathione, Chem. Biochem. Med. Aspects Pt. A (Dolphin D, Poulson R, Avromonic O, eds. ) John Wiley & Sons, New York 3, 553-596 (1989)
No PubMed abstract available

Data extracted from this reference:

Crystallization (Commentary)
Crystallization
Organism
molecular asymmetry of crystals from deionized water and from 2 M ammonium sulfate, exact 2fold molecular axis in the dimer, form A-D, three-dimensional structure
Homo sapiens
trigonal crystals, high internal symmetry
Escherichia coli
General Stability
General Stability
Organism
concentrated solution, stable for years
Mus musculus
concentrated solution, stable for years
Escherichia coli
concentrated solution, stable for years
Homo sapiens
concentrated solution, stable for years
Rattus norvegicus
concentrated solution, stable for years
Sus scrofa
concentrated solution, stable for years
Saccharomyces cerevisiae
concentrated solution, stable for years
Bos taurus
concentrated solution, stable for years
Oryctolagus cuniculus
concentrated solution, stable for years
Penicillium chrysogenum
concentrated solution, stable for years
Spinacia oleracea
concentrated solution, stable for years
Meriones unguiculatus
concentrated solution, stable for years
Allochromatium vinosum
concentrated solution, stable for years
Scombridae
concentrated solution, stable for years
Plasmodium vinckei
crystals and amorphous protein obtained by precipitation with ammonium sulfate are stable
Mus musculus
crystals and amorphous protein obtained by precipitation with ammonium sulfate are stable
Escherichia coli
crystals and amorphous protein obtained by precipitation with ammonium sulfate are stable
Homo sapiens
crystals and amorphous protein obtained by precipitation with ammonium sulfate are stable
Rattus norvegicus
crystals and amorphous protein obtained by precipitation with ammonium sulfate are stable
Sus scrofa
crystals and amorphous protein obtained by precipitation with ammonium sulfate are stable
Saccharomyces cerevisiae
crystals and amorphous protein obtained by precipitation with ammonium sulfate are stable
Bos taurus
crystals and amorphous protein obtained by precipitation with ammonium sulfate are stable
Oryctolagus cuniculus
crystals and amorphous protein obtained by precipitation with ammonium sulfate are stable
Penicillium chrysogenum
crystals and amorphous protein obtained by precipitation with ammonium sulfate are stable
Spinacia oleracea
crystals and amorphous protein obtained by precipitation with ammonium sulfate are stable
Meriones unguiculatus
crystals and amorphous protein obtained by precipitation with ammonium sulfate are stable
Allochromatium vinosum
crystals and amorphous protein obtained by precipitation with ammonium sulfate are stable
Scombridae
crystals and amorphous protein obtained by precipitation with ammonium sulfate are stable
Plasmodium vinckei
repeated freezing and thawing, inactivation
Mus musculus
repeated freezing and thawing, inactivation
Escherichia coli
repeated freezing and thawing, inactivation
Homo sapiens
repeated freezing and thawing, inactivation
Rattus norvegicus
repeated freezing and thawing, inactivation
Sus scrofa
repeated freezing and thawing, inactivation
Saccharomyces cerevisiae
repeated freezing and thawing, inactivation
Bos taurus
repeated freezing and thawing, inactivation
Oryctolagus cuniculus
repeated freezing and thawing, inactivation
Penicillium chrysogenum
repeated freezing and thawing, inactivation
Spinacia oleracea
repeated freezing and thawing, inactivation
Meriones unguiculatus
repeated freezing and thawing, inactivation
Allochromatium vinosum
repeated freezing and thawing, inactivation
Scombridae
repeated freezing and thawing, inactivation
Plasmodium vinckei
Inhibitors
Inhibitors
Commentary
Organism
Structure
1,2-Cyclohexanedione
-
Homo sapiens
1,3-Bis-(2-chloroethyl)-1-nitrosourea
-
Homo sapiens
1,3-Bis-(2-chloroethyl)-1-nitrosourea
-
Rattus norvegicus
1,3-Bis-(2-chloroethyl)-1-nitrosourea
-
Saccharomyces cerevisiae
1-(2-Chloroethyl)-3-(2-hydroxyethyl)-1-nitrosourea
-
Homo sapiens
1-chloro-2,4-dinitrobenzene
reversible
Homo sapiens
1-Fluoro-2,4-dinitrobenzene
reversible
Saccharomyces cerevisiae
2,3-Butanedione
-
Homo sapiens
2,4,6-Trinitrobenzenesulfonate
reversible
Bos taurus
2-Chloroethylisocyanate
-
Saccharomyces cerevisiae
arsenite
-
Homo sapiens
arsenite
-
Litomosoides carinii
arsenite
-
Rattus norvegicus
arsenite
-
Saccharomyces cerevisiae
Benzylselenosulfate
-
Rattus norvegicus
Cd2+
-
Homo sapiens
Cd2+
-
Scombridae
chromate
-
Allochromatium vinosum
chromate
-
Bos taurus
chromate
-
Escherichia coli
chromate
-
Homo sapiens
chromate
-
Meriones unguiculatus
chromate
-
Mus musculus
chromate
-
Oryctolagus cuniculus
chromate
-
Penicillium chrysogenum
chromate
-
Plasmodium vinckei
chromate
probably irreversible
Rattus norvegicus
chromate
-
Saccharomyces cerevisiae
chromate
-
Scombridae
chromate
-
Spinacia oleracea
chromate
-
Sus scrofa
Cu2+
-
Saccharomyces cerevisiae
Cu2+
-
Allochromatium vinosum
Dinitrosated isomers of N,N'-bis[N(2-chloroethyl)-N-carbonyl]cysteamine
-
Rattus norvegicus
Haemin
mediates covalent cross-linking and degradation of the enzyme
Saccharomyces cerevisiae
Hg2+
-
Rattus norvegicus
Iodine
-
Saccharomyces cerevisiae
iodoacetamide
-
Homo sapiens
iodoacetamide
-
Saccharomyces cerevisiae
Melarsen oxide
-
Homo sapiens
Melarsen oxide
-
Litomosoides carinii
additional information
regulation by inactivation in vivo, e.g. by disulfide bridging
Homo sapiens
additional information
regulation by inactivation in vivo, e.g. by disulfide bridging
Mus musculus
additional information
regulation by inactivation in vivo, e.g. by disulfide bridging
Saccharomyces cerevisiae
N,N'-bis(trans-4-hydroxycyclohexyl)-N'-nitrosourea
-
Rattus norvegicus
N-Alkylmaleimide
-
Saccharomyces cerevisiae
nifurtimox
-
Homo sapiens
nifurtimox
-
Rattus norvegicus
Nitrofurantoin
-
Allochromatium vinosum
Nitrofurantoin
-
Bos taurus
Nitrofurantoin
-
Escherichia coli
Nitrofurantoin
-
Homo sapiens
Nitrofurantoin
-
Meriones unguiculatus
Nitrofurantoin
-
Mus musculus
Nitrofurantoin
-
Oryctolagus cuniculus
Nitrofurantoin
-
Penicillium chrysogenum
Nitrofurantoin
-
Plasmodium vinckei
Nitrofurantoin
-
Rattus norvegicus
Nitrofurantoin
-
Saccharomyces cerevisiae
Nitrofurantoin
-
Scombridae
Nitrofurantoin
-
Spinacia oleracea
Nitrofurantoin
-
Sus scrofa
Nitrogen mustard
-
Homo sapiens
p-hydroxymercuribenzoate
-
Escherichia coli
p-hydroxymercuribenzoate
-
Oryctolagus cuniculus
p-hydroxymercuribenzoate
-
Rattus norvegicus
p-hydroxymercuribenzoate
-
Meriones unguiculatus
p-hydroxymercuribenzoate
-
Allochromatium vinosum
Phenylarsonous acid
-
Saccharomyces cerevisiae
Phenylglyoxal
-
Homo sapiens
Phenylglyoxal
-
Saccharomyces cerevisiae
S-(2,4-dinitrophenyl)-glutathione
-
Homo sapiens
Zn2+
-
Homo sapiens
Zn2+
-
Rattus norvegicus
Zn2+
-
Spinacia oleracea
KM Value [mM]
KM Value [mM]
KM Value Maximum [mM]
Substrate
Commentary
Organism
Structure
0.008
-
NADPH
-
Homo sapiens
0.008
-
NADPH
-
Oryctolagus cuniculus
0.008
-
NADPH
-
Rattus norvegicus
0.065
-
GSSG
-
Homo sapiens
0.25
-
glutathione-S-sulfonate
-
Saccharomyces cerevisiae
1
-
mixed disulfide of coenzyme A and glutathione
-
Homo sapiens
7
-
GSSG
-
Allochromatium vinosum
11.6
-
bis-N,N'-(gamma-glutamylcystine)
-
Saccharomyces cerevisiae
Localization
Localization
Commentary
Organism
GeneOntology No.
Textmining
chloroplast
cytoplasm-like spaces of chloroplasts
Spinacia oleracea
9507
-
cytoplasm
-
Bos taurus
5737
-
cytoplasm
-
Rattus norvegicus
5737
-
mitochondrion
cytoplasm-like spaces of mitochondria
Rattus norvegicus
5739
-
Molecular Weight [Da]
Molecular Weight [Da]
Molecular Weight Maximum [Da]
Commentary
Organism
52500
-
2 * 52500
Homo sapiens
Natural Substrates/ Products (Substrates)
Natural Substrates
Organism
Commentary (Nat. Sub.)
Natural Products
Commentary (Nat. Pro.)
Organism (Nat. Pro.)
Reversibility
GSSG + NADPH
Rattus norvegicus
-
glutathione + NADP+
-
-
?
GSSG + NADPH
Mus musculus
maintenance of glutathione/GSSG ratio is a protective mechanism for intracellular thiols during growth in atmospheric oxygen
glutathione + NADP+
-
-
?
GSSG + NADPH
Escherichia coli
maintenance of glutathione/GSSG ratio is a protective mechanism for intracellular thiols during growth in atmospheric oxygen
glutathione + NADP+
-
-
?
GSSG + NADPH
Homo sapiens
maintenance of glutathione/GSSG ratio is a protective mechanism for intracellular thiols during growth in atmospheric oxygen
glutathione + NADP+
-
-
?
GSSG + NADPH
Sus scrofa
maintenance of glutathione/GSSG ratio is a protective mechanism for intracellular thiols during growth in atmospheric oxygen
glutathione + NADP+
-
-
?
GSSG + NADPH
Saccharomyces cerevisiae
maintenance of glutathione/GSSG ratio is a protective mechanism for intracellular thiols during growth in atmospheric oxygen
glutathione + NADP+
-
-
?
GSSG + NADPH
Bos taurus
maintenance of glutathione/GSSG ratio is a protective mechanism for intracellular thiols during growth in atmospheric oxygen
glutathione + NADP+
-
-
?
GSSG + NADPH
Oryctolagus cuniculus
maintenance of glutathione/GSSG ratio is a protective mechanism for intracellular thiols during growth in atmospheric oxygen
glutathione + NADP+
-
-
?
GSSG + NADPH
Penicillium chrysogenum
maintenance of glutathione/GSSG ratio is a protective mechanism for intracellular thiols during growth in atmospheric oxygen
glutathione + NADP+
-
-
?
GSSG + NADPH
Spinacia oleracea
maintenance of glutathione/GSSG ratio is a protective mechanism for intracellular thiols during growth in atmospheric oxygen
glutathione + NADP+
-
-
?
GSSG + NADPH
Meriones unguiculatus
maintenance of glutathione/GSSG ratio is a protective mechanism for intracellular thiols during growth in atmospheric oxygen
glutathione + NADP+
-
-
?
GSSG + NADPH
Allochromatium vinosum
maintenance of glutathione/GSSG ratio is a protective mechanism for intracellular thiols during growth in atmospheric oxygen
glutathione + NADP+
-
-
?
GSSG + NADPH
Scombridae
maintenance of glutathione/GSSG ratio is a protective mechanism for intracellular thiols during growth in atmospheric oxygen
glutathione + NADP+
-
-
?
GSSG + NADPH
Plasmodium vinckei
maintenance of glutathione/GSSG ratio is a protective mechanism for intracellular thiols during growth in atmospheric oxygen
glutathione + NADP+
-
-
?
GSSG + NADPH
Bufo bufo
high GSSG level in dormant stage
glutathione + NADP+
-
-
?
additional information
Homo sapiens
glutathione redox cycle
?
-
-
-
Organism
Organism
Primary Accession No. (UniProt)
Commentary
Textmining
Allochromatium vinosum
-
-
-
Bos taurus
-
-
-
Bufo bufo
-
toad
-
Escherichia coli
-
-
-
Homo sapiens
-
-
-
Litomosoides carinii
-
-
-
Meriones unguiculatus
-
-
-
Mus musculus
-
-
-
Oryctolagus cuniculus
-
-
-
Penicillium chrysogenum
-
-
-
Plasmodium vinckei
-
-
-
Rattus norvegicus
-
-
-
Saccharomyces cerevisiae
-
baker's yeast
-
Scombridae
-
-
-
Spinacia oleracea
-
spinach
-
Sus scrofa
-
-
-
Purification (Commentary)
Commentary
Organism
partially
Litomosoides carinii
Reaction
Reaction
Commentary
Organism
2 glutathione + NADP+ = glutathione disulfide + NADPH + H+
mechanism
Escherichia coli
2 glutathione + NADP+ = glutathione disulfide + NADPH + H+
GSSG-binding site; mechanism
Homo sapiens
2 glutathione + NADP+ = glutathione disulfide + NADPH + H+
mechanism
Penicillium chrysogenum
2 glutathione + NADP+ = glutathione disulfide + NADPH + H+
mechanism
Rattus norvegicus
2 glutathione + NADP+ = glutathione disulfide + NADPH + H+
mechanism
Saccharomyces cerevisiae
Source Tissue
Source Tissue
Commentary
Organism
Textmining
erythrocyte
-
Oryctolagus cuniculus
-
erythrocyte
-
Sus scrofa
-
erythrocyte
-
Homo sapiens
-
leaf
-
Spinacia oleracea
-
lens fiber
-
Homo sapiens
-
leukocyte
-
Homo sapiens
-
liver
-
Meriones unguiculatus
-
liver
-
Oryctolagus cuniculus
-
liver
-
Mus musculus
-
liver
-
Bos taurus
-
liver
-
Rattus norvegicus
-
muscle
-
Scombridae
-
platelet
-
Homo sapiens
-
Specific Activity [micromol/min/mg]
Specific Activity Minimum [mol/min/mg]
Specific Activity Maximum [mol/min/mg]
Commentary
Organism
additional information
-
-
Bos taurus
additional information
-
-
Escherichia coli
additional information
-
activity decreases with age of the organism
Homo sapiens
additional information
-
activity decreases with age of the organism
Mus musculus
additional information
-
activity decreases with age of the organism
Rattus norvegicus
240
-
-
Homo sapiens
Storage Stability
Storage Stability
Organism
4C, activation after storage over days, months or years
Mus musculus
4C, activation after storage over days, months or years
Escherichia coli
4C, activation after storage over days, months or years
Homo sapiens
4C, activation after storage over days, months or years
Rattus norvegicus
4C, activation after storage over days, months or years
Sus scrofa
4C, activation after storage over days, months or years
Saccharomyces cerevisiae
4C, activation after storage over days, months or years
Bos taurus
4C, activation after storage over days, months or years
Oryctolagus cuniculus
4C, activation after storage over days, months or years
Penicillium chrysogenum
4C, activation after storage over days, months or years
Spinacia oleracea
4C, activation after storage over days, months or years
Meriones unguiculatus
4C, activation after storage over days, months or years
Allochromatium vinosum
4C, activation after storage over days, months or years
Scombridae
4C, activation after storage over days, months or years
Plasmodium vinckei
concentrated solution, years
Mus musculus
concentrated solution, years
Escherichia coli
concentrated solution, years
Homo sapiens
concentrated solution, years
Rattus norvegicus
concentrated solution, years
Sus scrofa
concentrated solution, years
Saccharomyces cerevisiae
concentrated solution, years
Bos taurus
concentrated solution, years
Oryctolagus cuniculus
concentrated solution, years
Penicillium chrysogenum
concentrated solution, years
Spinacia oleracea
concentrated solution, years
Meriones unguiculatus
concentrated solution, years
Allochromatium vinosum
concentrated solution, years
Scombridae
concentrated solution, years
Plasmodium vinckei
Substrates and Products (Substrate)
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
GSSG + NADPH
-
394708
Mus musculus
glutathione + NADP+
-
394708
Mus musculus
r
GSSG + NADPH
-
394708
Rattus norvegicus
glutathione + NADP+
-
-
-
?
GSSG + NADPH
-
394708
Sus scrofa
glutathione + NADP+
-
394708
Sus scrofa
?
GSSG + NADPH
-
394708
Sus scrofa
glutathione + NADP+
-
394708
Sus scrofa
r
GSSG + NADPH
-
394708
Bos taurus
glutathione + NADP+
-
394708
Bos taurus
?
GSSG + NADPH
-
394708
Bos taurus
glutathione + NADP+
-
394708
Bos taurus
ir
GSSG + NADPH
-
394708
Bos taurus
glutathione + NADP+
-
394708
Bos taurus
r
GSSG + NADPH
-
394708
Oryctolagus cuniculus
glutathione + NADP+
-
394708
Oryctolagus cuniculus
?
GSSG + NADPH
-
394708
Oryctolagus cuniculus
glutathione + NADP+
-
394708
Oryctolagus cuniculus
r
GSSG + NADPH
-
394708
Spinacia oleracea
glutathione + NADP+
-
394708
Spinacia oleracea
?
GSSG + NADPH
-
394708
Spinacia oleracea
glutathione + NADP+
-
394708
Spinacia oleracea
r
GSSG + NADPH
-
394708
Meriones unguiculatus
glutathione + NADP+
-
394708
Meriones unguiculatus
r
GSSG + NADPH
-
394708
Allochromatium vinosum
glutathione + NADP+
-
394708
Allochromatium vinosum
r
GSSG + NADPH
-
394708
Scombridae
glutathione + NADP+
-
394708
Scombridae
r
GSSG + NADPH
-
394708
Plasmodium vinckei
glutathione + NADP+
-
394708
Plasmodium vinckei
r
GSSG + NADPH
-
394708
Litomosoides carinii
glutathione + NADP+
-
394708
Litomosoides carinii
?
GSSG + NADPH
-
394708
Litomosoides carinii
glutathione + NADP+
-
394708
Litomosoides carinii
r
GSSG + NADPH
-
394708
Bufo bufo
glutathione + NADP+
-
394708
Bufo bufo
r
GSSG + NADPH
glutathione or other disulfides, e.g.: bis-L-gamma-glutamyl-L-cystinyl-bis-beta-alanine
394708
Escherichia coli
glutathione + NADP+
-
394708
Escherichia coli
?
GSSG + NADPH
glutathione or other disulfides, e.g.: bis-L-gamma-glutamyl-L-cystinyl-bis-beta-alanine
394708
Escherichia coli
glutathione + NADP+
-
394708
Escherichia coli
ir
GSSG + NADPH
glutathione or other disulfides, e.g.: bis-L-gamma-glutamyl-L-cystinyl-bis-beta-alanine
394708
Escherichia coli
glutathione + NADP+
-
394708
Escherichia coli
r
GSSG + NADPH
glutathione or other disulfides, e.g.: bis-L-gamma-glutamyl-L-cystinyl-bis-beta-alanine
394708
Rattus norvegicus
glutathione + NADP+
-
394708
Rattus norvegicus
?
GSSG + NADPH
glutathione or other disulfides, e.g.: bis-L-gamma-glutamyl-L-cystinyl-bis-beta-alanine
394708
Rattus norvegicus
glutathione + NADP+
-
394708
Rattus norvegicus
ir
GSSG + NADPH
glutathione or other disulfides, e.g.: bis-L-gamma-glutamyl-L-cystinyl-bis-beta-alanine
394708
Rattus norvegicus
glutathione + NADP+
-
394708
Rattus norvegicus
r
GSSG + NADPH
glutathione or other disulfides, e.g.: bis-L-gamma-glutamyl-L-cystinyl-bis-beta-alanine
394708
Saccharomyces cerevisiae
glutathione + NADP+
-
394708
Saccharomyces cerevisiae
?
GSSG + NADPH
glutathione or other disulfides, e.g.: bis-L-gamma-glutamyl-L-cystinyl-bis-beta-alanine
394708
Saccharomyces cerevisiae
glutathione + NADP+
-
394708
Saccharomyces cerevisiae
r
GSSG + NADPH
glutathione or other disulfides, e.g.: bis-L-gamma-glutamyl-L-cystinyl-bis-beta-alanine
394708
Penicillium chrysogenum
glutathione + NADP+
-
394708
Penicillium chrysogenum
?
GSSG + NADPH
glutathione or other disulfides, e.g.: bis-L-gamma-glutamyl-L-cystinyl-bis-beta-alanine
394708
Penicillium chrysogenum
glutathione + NADP+
-
394708
Penicillium chrysogenum
r
GSSG + NADPH
slight activity with D,L-lipoate
394708
Homo sapiens
glutathione + NADP+
-
394708
Homo sapiens
?
GSSG + NADPH
slight activity with D,L-lipoate
394708
Homo sapiens
glutathione + NADP+
-
394708
Homo sapiens
ir
GSSG + NADPH
slight activity with D,L-lipoate
394708
Homo sapiens
glutathione + NADP+
-
394708
Homo sapiens
r
GSSG + NADPH
mixed disulfide between coenzyme A and glutathione
394708
Homo sapiens
glutathione + NADP+
-
394708
Homo sapiens
?
GSSG + NADPH
mixed disulfide between coenzyme A and glutathione
394708
Homo sapiens
glutathione + NADP+
-
394708
Homo sapiens
ir
GSSG + NADPH
mixed disulfide between coenzyme A and glutathione
394708
Homo sapiens
glutathione + NADP+
-
394708
Homo sapiens
r
GSSG + NADPH
mixed disulfide between coenzyme A and glutathione
394708
Rattus norvegicus
glutathione + NADP+
-
394708
Rattus norvegicus
?
GSSG + NADPH
mixed disulfide between coenzyme A and glutathione
394708
Rattus norvegicus
glutathione + NADP+
-
394708
Rattus norvegicus
ir
GSSG + NADPH
mixed disulfide between coenzyme A and glutathione
394708
Rattus norvegicus
glutathione + NADP+
-
394708
Rattus norvegicus
r
GSSG + NADPH
mixed disulfide between coenzyme A and glutathione
394708
Saccharomyces cerevisiae
glutathione + NADP+
-
394708
Saccharomyces cerevisiae
?
GSSG + NADPH
mixed disulfide between coenzyme A and glutathione
394708
Saccharomyces cerevisiae
glutathione + NADP+
-
394708
Saccharomyces cerevisiae
r
GSSG + NADPH
slight activity with bis-N,N'-(gamma-glutamylcystine)
394708
Saccharomyces cerevisiae
glutathione + NADP+
-
394708
Saccharomyces cerevisiae
?
GSSG + NADPH
slight activity with bis-N,N'-(gamma-glutamylcystine)
394708
Saccharomyces cerevisiae
glutathione + NADP+
-
394708
Saccharomyces cerevisiae
r
GSSG + NADPH
glutathione-S-sulfonate
394708
Saccharomyces cerevisiae
glutathione + NADP+
-
394708
Saccharomyces cerevisiae
?
GSSG + NADPH
glutathione-S-sulfonate
394708
Saccharomyces cerevisiae
glutathione + NADP+
-
394708
Saccharomyces cerevisiae
r
GSSG + NADPH
maintenance of glutathione/GSSG ratio is a protective mechanism for intracellular thiols during growth in atmospheric oxygen
394708
Mus musculus
glutathione + NADP+
-
-
-
?
GSSG + NADPH
maintenance of glutathione/GSSG ratio is a protective mechanism for intracellular thiols during growth in atmospheric oxygen
394708
Escherichia coli
glutathione + NADP+
-
-
-
?
GSSG + NADPH
maintenance of glutathione/GSSG ratio is a protective mechanism for intracellular thiols during growth in atmospheric oxygen
394708
Homo sapiens
glutathione + NADP+
-
-
-
?
GSSG + NADPH
maintenance of glutathione/GSSG ratio is a protective mechanism for intracellular thiols during growth in atmospheric oxygen
394708
Sus scrofa
glutathione + NADP+
-
-
-
?
GSSG + NADPH
maintenance of glutathione/GSSG ratio is a protective mechanism for intracellular thiols during growth in atmospheric oxygen
394708
Saccharomyces cerevisiae
glutathione + NADP+
-
-
-
?
GSSG + NADPH
maintenance of glutathione/GSSG ratio is a protective mechanism for intracellular thiols during growth in atmospheric oxygen
394708
Bos taurus
glutathione + NADP+
-
-
-
?
GSSG + NADPH
maintenance of glutathione/GSSG ratio is a protective mechanism for intracellular thiols during growth in atmospheric oxygen
394708
Oryctolagus cuniculus
glutathione + NADP+
-
-
-
?
GSSG + NADPH
maintenance of glutathione/GSSG ratio is a protective mechanism for intracellular thiols during growth in atmospheric oxygen
394708
Penicillium chrysogenum
glutathione + NADP+
-
-
-
?
GSSG + NADPH
maintenance of glutathione/GSSG ratio is a protective mechanism for intracellular thiols during growth in atmospheric oxygen
394708
Spinacia oleracea
glutathione + NADP+
-
-
-
?
GSSG + NADPH
maintenance of glutathione/GSSG ratio is a protective mechanism for intracellular thiols during growth in atmospheric oxygen
394708
Meriones unguiculatus
glutathione + NADP+
-
-
-
?
GSSG + NADPH
maintenance of glutathione/GSSG ratio is a protective mechanism for intracellular thiols during growth in atmospheric oxygen
394708
Allochromatium vinosum
glutathione + NADP+
-
-
-
?
GSSG + NADPH
maintenance of glutathione/GSSG ratio is a protective mechanism for intracellular thiols during growth in atmospheric oxygen
394708
Scombridae
glutathione + NADP+
-
-
-
?
GSSG + NADPH
maintenance of glutathione/GSSG ratio is a protective mechanism for intracellular thiols during growth in atmospheric oxygen
394708
Plasmodium vinckei
glutathione + NADP+
-
-
-
?
GSSG + NADPH
high GSSG level in dormant stage
394708
Bufo bufo
glutathione + NADP+
-
-
-
?
additional information
-
394708
Mus musculus
?
-
-
-
-
additional information
-
394708
Rattus norvegicus
?
-
-
-
-
additional information
-
394708
Sus scrofa
?
-
-
-
-
additional information
-
394708
Saccharomyces cerevisiae
?
-
-
-
-
additional information
-
394708
Spinacia oleracea
?
-
-
-
-
additional information
-
394708
Meriones unguiculatus
?
-
-
-
-
additional information
-
394708
Allochromatium vinosum
?
-
-
-
-
additional information
glutathione redox cycle
394708
Homo sapiens
?
-
-
-
-
Subunits
Subunits
Commentary
Organism
dimer
-
Meriones unguiculatus
dimer
-
Mus musculus
dimer
-
Oryctolagus cuniculus
dimer
-
Spinacia oleracea
dimer
-
Sus scrofa
dimer
-
Rattus norvegicus
dimer
2 * 52500
Homo sapiens
dimer
-
Escherichia coli
dimer
-
Bos taurus
Turnover Number [1/s]
Turnover Number Minimum [1/s]
Turnover Number Maximum [1/s]
Substrate
Commentary
Organism
Structure
210
-
GSSG
-
Homo sapiens
Cofactor
Cofactor
Commentary
Organism
Structure
FAD
FAD enzyme
Escherichia coli
FAD
FAD enzyme
Meriones unguiculatus
FAD
FAD enzyme
Mus musculus
FAD
FAD enzyme
Penicillium chrysogenum
FAD
FAD enzyme
Plasmodium vinckei
FAD
FAD enzyme
Rattus norvegicus
FAD
FAD enzyme
Scombridae
FAD
FAD enzyme
Sus scrofa
FAD
FAD enzyme
Oryctolagus cuniculus
FAD
FAD enzyme
Spinacia oleracea
FAD
FAD enzyme
Allochromatium vinosum
FAD
FAD enzyme
Bos taurus
FAD
FAD enzyme
Saccharomyces cerevisiae
FAD
FAD enzyme
Homo sapiens
flavin
flavoprotein
Allochromatium vinosum
flavin
flavoprotein
Homo sapiens
flavin
flavoprotein
Meriones unguiculatus
flavin
flavoprotein
Mus musculus
flavin
flavoprotein
Oryctolagus cuniculus
flavin
flavoprotein
Penicillium chrysogenum
flavin
flavoprotein
Plasmodium vinckei
flavin
flavoprotein
Saccharomyces cerevisiae
flavin
flavoprotein
Scombridae
flavin
flavoprotein
Spinacia oleracea
flavin
flavoprotein
Sus scrofa
flavin
flavoprotein
Bos taurus
flavin
flavoprotein
Rattus norvegicus
flavin
flavoprotein
Escherichia coli
NADH
-
Allochromatium vinosum
NADH
20times less activity than with NADPH
Homo sapiens
NADH
-
Rattus norvegicus
NADH
-
Spinacia oleracea
NADH
-
Sus scrofa
NADPH
can utilize both NADPH and NADH, more active with NADPH
Allochromatium vinosum
NADPH
-
Bufo bufo
NADPH
20times more activity than with NADH; can utilize both NADPH and NADH, more active with NADPH
Homo sapiens
NADPH
-
Litomosoides carinii
NADPH
-
Meriones unguiculatus
NADPH
-
Penicillium chrysogenum
NADPH
-
Plasmodium vinckei
NADPH
-
Scombridae
NADPH
-
Oryctolagus cuniculus
NADPH
-
Sus scrofa
NADPH
-
Escherichia coli
NADPH
-
Mus musculus
NADPH
-
Saccharomyces cerevisiae
NADPH
-
Spinacia oleracea
NADPH
-
Bos taurus
NADPH
-
Rattus norvegicus
Ki Value [mM]
Ki Value [mM]
Ki Value maximum [mM]
Inhibitor
Commentary
Organism
Structure
0.00033
-
Hg2+
-
Rattus norvegicus
0.0005
-
2,4,6-trinitrobenzene-sulfonate
below, at 50% inhibition value, leading to oxidase activity
Bos taurus
0.0008
-
Zn2+
at 50% inhibition value
Homo sapiens
0.001
-
Cd2+
at 50% inhibition value
Homo sapiens
0.001
-
Cu2+
at 50% inhibition value
Saccharomyces cerevisiae
0.001
-
Nitrofurantoin
at 50% inhibition value, enzyme partially purified from platelets
Homo sapiens
0.005
-
Zn2+
at 50% inhibition value
Homo sapiens
0.0065
-
Zn2+
at 50% inhibition value
Rattus norvegicus
0.0091
-
Melarsen oxide
at 50% inhibition value
Litomosoides carinii
0.01
-
p-hydroxymercuribenzoate
-
Escherichia coli
0.02
-
Nitrofurantoin
at 50% inhibition value
Rattus norvegicus
0.022
-
1-chloro-2,4-dinitrobenzene
at 50% inhibition value
Homo sapiens
0.025
-
Nitrofurantoin
at 50% inhibition value, enzyme from erythrocytes
Homo sapiens
0.03
-
nifurtimox
at 50% inhibition value
Rattus norvegicus
0.03
-
S-(2,4-dinitrophenyl)-glutathione
at 50% inhibition value
Homo sapiens
0.04
-
nifurtimox
at 50% inhibition value
Homo sapiens
0.25
-
Cd2+
-
Scombridae
0.25
-
Melarsen oxide
at 50% inhibition value
Homo sapiens
0.35
-
chromate
at 50% inhibition value
Homo sapiens
0.35
-
chromate
-
Rattus norvegicus
1.1
-
Nitrogen mustard
at 50% inhibition value
Homo sapiens
2.2
9
arsenite
at 50% inhibition value
Homo sapiens
3
-
arsenite
at 50% inhibition value
Litomosoides carinii
Cofactor (protein specific)
Cofactor
Commentary
Organism
Structure
FAD
FAD enzyme
Escherichia coli
FAD
FAD enzyme
Meriones unguiculatus
FAD
FAD enzyme
Mus musculus
FAD
FAD enzyme
Penicillium chrysogenum
FAD
FAD enzyme
Plasmodium vinckei
FAD
FAD enzyme
Rattus norvegicus
FAD
FAD enzyme
Scombridae
FAD
FAD enzyme
Sus scrofa
FAD
FAD enzyme
Oryctolagus cuniculus
FAD
FAD enzyme
Spinacia oleracea
FAD
FAD enzyme
Allochromatium vinosum
FAD
FAD enzyme
Bos taurus
FAD
FAD enzyme
Saccharomyces cerevisiae
FAD
FAD enzyme
Homo sapiens
flavin
flavoprotein
Allochromatium vinosum
flavin
flavoprotein
Homo sapiens
flavin
flavoprotein
Meriones unguiculatus
flavin
flavoprotein
Mus musculus
flavin
flavoprotein
Oryctolagus cuniculus
flavin
flavoprotein
Penicillium chrysogenum
flavin
flavoprotein
Plasmodium vinckei
flavin
flavoprotein
Saccharomyces cerevisiae
flavin
flavoprotein
Scombridae
flavin
flavoprotein
Spinacia oleracea
flavin
flavoprotein
Sus scrofa
flavin
flavoprotein
Bos taurus
flavin
flavoprotein
Rattus norvegicus
flavin
flavoprotein
Escherichia coli
NADH
-
Allochromatium vinosum
NADH
20times less activity than with NADPH
Homo sapiens
NADH
-
Rattus norvegicus
NADH
-
Spinacia oleracea
NADH
-
Sus scrofa
NADPH
can utilize both NADPH and NADH, more active with NADPH
Allochromatium vinosum
NADPH
-
Bufo bufo
NADPH
20times more activity than with NADH; can utilize both NADPH and NADH, more active with NADPH
Homo sapiens
NADPH
-
Litomosoides carinii
NADPH
-
Meriones unguiculatus
NADPH
-
Penicillium chrysogenum
NADPH
-
Plasmodium vinckei
NADPH
-
Scombridae
NADPH
-
Oryctolagus cuniculus
NADPH
-
Sus scrofa
NADPH
-
Escherichia coli
NADPH
-
Mus musculus
NADPH
-
Saccharomyces cerevisiae
NADPH
-
Spinacia oleracea
NADPH
-
Bos taurus
NADPH
-
Rattus norvegicus
Crystallization (Commentary) (protein specific)
Crystallization
Organism
molecular asymmetry of crystals from deionized water and from 2 M ammonium sulfate, exact 2fold molecular axis in the dimer, form A-D, three-dimensional structure
Homo sapiens
trigonal crystals, high internal symmetry
Escherichia coli
General Stability (protein specific)
General Stability
Organism
concentrated solution, stable for years
Mus musculus
concentrated solution, stable for years
Escherichia coli
concentrated solution, stable for years
Homo sapiens
concentrated solution, stable for years
Rattus norvegicus
concentrated solution, stable for years
Sus scrofa
concentrated solution, stable for years
Saccharomyces cerevisiae
concentrated solution, stable for years
Bos taurus
concentrated solution, stable for years
Oryctolagus cuniculus
concentrated solution, stable for years
Penicillium chrysogenum
concentrated solution, stable for years
Spinacia oleracea
concentrated solution, stable for years
Meriones unguiculatus
concentrated solution, stable for years
Allochromatium vinosum
concentrated solution, stable for years
Scombridae
concentrated solution, stable for years
Plasmodium vinckei
crystals and amorphous protein obtained by precipitation with ammonium sulfate are stable
Mus musculus
crystals and amorphous protein obtained by precipitation with ammonium sulfate are stable
Escherichia coli
crystals and amorphous protein obtained by precipitation with ammonium sulfate are stable
Homo sapiens
crystals and amorphous protein obtained by precipitation with ammonium sulfate are stable
Rattus norvegicus
crystals and amorphous protein obtained by precipitation with ammonium sulfate are stable
Sus scrofa
crystals and amorphous protein obtained by precipitation with ammonium sulfate are stable
Saccharomyces cerevisiae
crystals and amorphous protein obtained by precipitation with ammonium sulfate are stable
Bos taurus
crystals and amorphous protein obtained by precipitation with ammonium sulfate are stable
Oryctolagus cuniculus
crystals and amorphous protein obtained by precipitation with ammonium sulfate are stable
Penicillium chrysogenum
crystals and amorphous protein obtained by precipitation with ammonium sulfate are stable
Spinacia oleracea
crystals and amorphous protein obtained by precipitation with ammonium sulfate are stable
Meriones unguiculatus
crystals and amorphous protein obtained by precipitation with ammonium sulfate are stable
Allochromatium vinosum
crystals and amorphous protein obtained by precipitation with ammonium sulfate are stable
Scombridae
crystals and amorphous protein obtained by precipitation with ammonium sulfate are stable
Plasmodium vinckei
repeated freezing and thawing, inactivation
Mus musculus
repeated freezing and thawing, inactivation
Escherichia coli
repeated freezing and thawing, inactivation
Homo sapiens
repeated freezing and thawing, inactivation
Rattus norvegicus
repeated freezing and thawing, inactivation
Sus scrofa
repeated freezing and thawing, inactivation
Saccharomyces cerevisiae
repeated freezing and thawing, inactivation
Bos taurus
repeated freezing and thawing, inactivation
Oryctolagus cuniculus
repeated freezing and thawing, inactivation
Penicillium chrysogenum
repeated freezing and thawing, inactivation
Spinacia oleracea
repeated freezing and thawing, inactivation
Meriones unguiculatus
repeated freezing and thawing, inactivation
Allochromatium vinosum
repeated freezing and thawing, inactivation
Scombridae
repeated freezing and thawing, inactivation
Plasmodium vinckei
Inhibitors (protein specific)
Inhibitors
Commentary
Organism
Structure
1,2-Cyclohexanedione
-
Homo sapiens
1,3-Bis-(2-chloroethyl)-1-nitrosourea
-
Homo sapiens
1,3-Bis-(2-chloroethyl)-1-nitrosourea
-
Rattus norvegicus
1,3-Bis-(2-chloroethyl)-1-nitrosourea
-
Saccharomyces cerevisiae
1-(2-Chloroethyl)-3-(2-hydroxyethyl)-1-nitrosourea
-
Homo sapiens
1-chloro-2,4-dinitrobenzene
reversible
Homo sapiens
1-Fluoro-2,4-dinitrobenzene
reversible
Saccharomyces cerevisiae
2,3-Butanedione
-
Homo sapiens
2,4,6-Trinitrobenzenesulfonate
reversible
Bos taurus
2-Chloroethylisocyanate
-
Saccharomyces cerevisiae
arsenite
-
Homo sapiens
arsenite
-
Litomosoides carinii
arsenite
-
Rattus norvegicus
arsenite
-
Saccharomyces cerevisiae
Benzylselenosulfate
-
Rattus norvegicus
Cd2+
-
Homo sapiens
Cd2+
-
Scombridae
chromate
-
Allochromatium vinosum
chromate
-
Bos taurus
chromate
-
Escherichia coli
chromate
-
Homo sapiens
chromate
-
Meriones unguiculatus
chromate
-
Mus musculus
chromate
-
Oryctolagus cuniculus
chromate
-
Penicillium chrysogenum
chromate
-
Plasmodium vinckei
chromate
probably irreversible
Rattus norvegicus
chromate
-
Saccharomyces cerevisiae
chromate
-
Scombridae
chromate
-
Spinacia oleracea
chromate
-
Sus scrofa
Cu2+
-
Saccharomyces cerevisiae
Cu2+
-
Allochromatium vinosum
Dinitrosated isomers of N,N'-bis[N(2-chloroethyl)-N-carbonyl]cysteamine
-
Rattus norvegicus
Haemin
mediates covalent cross-linking and degradation of the enzyme
Saccharomyces cerevisiae
Hg2+
-
Rattus norvegicus
Iodine
-
Saccharomyces cerevisiae
iodoacetamide
-
Homo sapiens
iodoacetamide
-
Saccharomyces cerevisiae
Melarsen oxide
-
Homo sapiens
Melarsen oxide
-
Litomosoides carinii
additional information
regulation by inactivation in vivo, e.g. by disulfide bridging
Homo sapiens
additional information
regulation by inactivation in vivo, e.g. by disulfide bridging
Mus musculus
additional information
regulation by inactivation in vivo, e.g. by disulfide bridging
Saccharomyces cerevisiae
N,N'-bis(trans-4-hydroxycyclohexyl)-N'-nitrosourea
-
Rattus norvegicus
N-Alkylmaleimide
-
Saccharomyces cerevisiae
nifurtimox
-
Homo sapiens
nifurtimox
-
Rattus norvegicus
Nitrofurantoin
-
Allochromatium vinosum
Nitrofurantoin
-
Bos taurus
Nitrofurantoin
-
Escherichia coli
Nitrofurantoin
-
Homo sapiens
Nitrofurantoin
-
Meriones unguiculatus
Nitrofurantoin
-
Mus musculus
Nitrofurantoin
-
Oryctolagus cuniculus
Nitrofurantoin
-
Penicillium chrysogenum
Nitrofurantoin
-
Plasmodium vinckei
Nitrofurantoin
-
Rattus norvegicus
Nitrofurantoin
-
Saccharomyces cerevisiae
Nitrofurantoin
-
Scombridae
Nitrofurantoin
-
Spinacia oleracea
Nitrofurantoin
-
Sus scrofa
Nitrogen mustard
-
Homo sapiens
p-hydroxymercuribenzoate
-
Escherichia coli
p-hydroxymercuribenzoate
-
Oryctolagus cuniculus
p-hydroxymercuribenzoate
-
Rattus norvegicus
p-hydroxymercuribenzoate
-
Meriones unguiculatus
p-hydroxymercuribenzoate
-
Allochromatium vinosum
Phenylarsonous acid
-
Saccharomyces cerevisiae
Phenylglyoxal
-
Homo sapiens
Phenylglyoxal
-
Saccharomyces cerevisiae
S-(2,4-dinitrophenyl)-glutathione
-
Homo sapiens
Zn2+
-
Homo sapiens
Zn2+
-
Rattus norvegicus
Zn2+
-
Spinacia oleracea
Ki Value [mM] (protein specific)
Ki Value [mM]
Ki Value maximum [mM]
Inhibitor
Commentary
Organism
Structure
0.00033
-
Hg2+
-
Rattus norvegicus
0.0005
-
2,4,6-trinitrobenzene-sulfonate
below, at 50% inhibition value, leading to oxidase activity
Bos taurus
0.0008
-
Zn2+
at 50% inhibition value
Homo sapiens
0.001
-
Cd2+
at 50% inhibition value
Homo sapiens
0.001
-
Cu2+
at 50% inhibition value
Saccharomyces cerevisiae
0.001
-
Nitrofurantoin
at 50% inhibition value, enzyme partially purified from platelets
Homo sapiens
0.005
-
Zn2+
at 50% inhibition value
Homo sapiens
0.0065
-
Zn2+
at 50% inhibition value
Rattus norvegicus
0.0091
-
Melarsen oxide
at 50% inhibition value
Litomosoides carinii
0.01
-
p-hydroxymercuribenzoate
-
Escherichia coli
0.02
-
Nitrofurantoin
at 50% inhibition value
Rattus norvegicus
0.022
-
1-chloro-2,4-dinitrobenzene
at 50% inhibition value
Homo sapiens
0.025
-
Nitrofurantoin
at 50% inhibition value, enzyme from erythrocytes
Homo sapiens
0.03
-
nifurtimox
at 50% inhibition value
Rattus norvegicus
0.03
-
S-(2,4-dinitrophenyl)-glutathione
at 50% inhibition value
Homo sapiens
0.04
-
nifurtimox
at 50% inhibition value
Homo sapiens
0.25
-
Cd2+
-
Scombridae
0.25
-
Melarsen oxide
at 50% inhibition value
Homo sapiens
0.35
-
chromate
at 50% inhibition value
Homo sapiens
0.35
-
chromate
-
Rattus norvegicus
1.1
-
Nitrogen mustard
at 50% inhibition value
Homo sapiens
2.2
9
arsenite
at 50% inhibition value
Homo sapiens
3
-
arsenite
at 50% inhibition value
Litomosoides carinii
KM Value [mM] (protein specific)
KM Value [mM]
KM Value Maximum [mM]
Substrate
Commentary
Organism
Structure
0.008
-
NADPH
-
Homo sapiens
0.008
-
NADPH
-
Oryctolagus cuniculus
0.008
-
NADPH
-
Rattus norvegicus
0.065
-
GSSG
-
Homo sapiens
0.25
-
glutathione-S-sulfonate
-
Saccharomyces cerevisiae
1
-
mixed disulfide of coenzyme A and glutathione
-
Homo sapiens
7
-
GSSG
-
Allochromatium vinosum
11.6
-
bis-N,N'-(gamma-glutamylcystine)
-
Saccharomyces cerevisiae
Localization (protein specific)
Localization
Commentary
Organism
GeneOntology No.
Textmining
chloroplast
cytoplasm-like spaces of chloroplasts
Spinacia oleracea
9507
-
cytoplasm
-
Bos taurus
5737
-
cytoplasm
-
Rattus norvegicus
5737
-
mitochondrion
cytoplasm-like spaces of mitochondria
Rattus norvegicus
5739
-
Molecular Weight [Da] (protein specific)
Molecular Weight [Da]
Molecular Weight Maximum [Da]
Commentary
Organism
52500
-
2 * 52500
Homo sapiens
Natural Substrates/ Products (Substrates) (protein specific)
Natural Substrates
Organism
Commentary (Nat. Sub.)
Natural Products
Commentary (Nat. Pro.)
Organism (Nat. Pro.)
Reversibility
GSSG + NADPH
Rattus norvegicus
-
glutathione + NADP+
-
-
?
GSSG + NADPH
Mus musculus
maintenance of glutathione/GSSG ratio is a protective mechanism for intracellular thiols during growth in atmospheric oxygen
glutathione + NADP+
-
-
?
GSSG + NADPH
Escherichia coli
maintenance of glutathione/GSSG ratio is a protective mechanism for intracellular thiols during growth in atmospheric oxygen
glutathione + NADP+
-
-
?
GSSG + NADPH
Homo sapiens
maintenance of glutathione/GSSG ratio is a protective mechanism for intracellular thiols during growth in atmospheric oxygen
glutathione + NADP+
-
-
?
GSSG + NADPH
Sus scrofa
maintenance of glutathione/GSSG ratio is a protective mechanism for intracellular thiols during growth in atmospheric oxygen
glutathione + NADP+
-
-
?
GSSG + NADPH
Saccharomyces cerevisiae
maintenance of glutathione/GSSG ratio is a protective mechanism for intracellular thiols during growth in atmospheric oxygen
glutathione + NADP+
-
-
?
GSSG + NADPH
Bos taurus
maintenance of glutathione/GSSG ratio is a protective mechanism for intracellular thiols during growth in atmospheric oxygen
glutathione + NADP+
-
-
?
GSSG + NADPH
Oryctolagus cuniculus
maintenance of glutathione/GSSG ratio is a protective mechanism for intracellular thiols during growth in atmospheric oxygen
glutathione + NADP+
-
-
?
GSSG + NADPH
Penicillium chrysogenum
maintenance of glutathione/GSSG ratio is a protective mechanism for intracellular thiols during growth in atmospheric oxygen
glutathione + NADP+
-
-
?
GSSG + NADPH
Spinacia oleracea
maintenance of glutathione/GSSG ratio is a protective mechanism for intracellular thiols during growth in atmospheric oxygen
glutathione + NADP+
-
-
?
GSSG + NADPH
Meriones unguiculatus
maintenance of glutathione/GSSG ratio is a protective mechanism for intracellular thiols during growth in atmospheric oxygen
glutathione + NADP+
-
-
?
GSSG + NADPH
Allochromatium vinosum
maintenance of glutathione/GSSG ratio is a protective mechanism for intracellular thiols during growth in atmospheric oxygen
glutathione + NADP+
-
-
?
GSSG + NADPH
Scombridae
maintenance of glutathione/GSSG ratio is a protective mechanism for intracellular thiols during growth in atmospheric oxygen
glutathione + NADP+
-
-
?
GSSG + NADPH
Plasmodium vinckei
maintenance of glutathione/GSSG ratio is a protective mechanism for intracellular thiols during growth in atmospheric oxygen
glutathione + NADP+
-
-
?
GSSG + NADPH
Bufo bufo
high GSSG level in dormant stage
glutathione + NADP+
-
-
?
additional information
Homo sapiens
glutathione redox cycle
?
-
-
-
Purification (Commentary) (protein specific)
Commentary
Organism
partially
Litomosoides carinii
Source Tissue (protein specific)
Source Tissue
Commentary
Organism
Textmining
erythrocyte
-
Oryctolagus cuniculus
-
erythrocyte
-
Sus scrofa
-
erythrocyte
-
Homo sapiens
-
leaf
-
Spinacia oleracea
-
lens fiber
-
Homo sapiens
-
leukocyte
-
Homo sapiens
-
liver
-
Meriones unguiculatus
-
liver
-
Oryctolagus cuniculus
-
liver
-
Mus musculus
-
liver
-
Bos taurus
-
liver
-
Rattus norvegicus
-
muscle
-
Scombridae
-
platelet
-
Homo sapiens
-
Specific Activity [micromol/min/mg] (protein specific)
Specific Activity Minimum [mol/min/mg]
Specific Activity Maximum [mol/min/mg]
Commentary
Organism
additional information
-
-
Bos taurus
additional information
-
-
Escherichia coli
additional information
-
activity decreases with age of the organism
Homo sapiens
additional information
-
activity decreases with age of the organism
Mus musculus
additional information
-
activity decreases with age of the organism
Rattus norvegicus
240
-
-
Homo sapiens
Storage Stability (protein specific)
Storage Stability
Organism
4C, activation after storage over days, months or years
Mus musculus
4C, activation after storage over days, months or years
Escherichia coli
4C, activation after storage over days, months or years
Homo sapiens
4C, activation after storage over days, months or years
Rattus norvegicus
4C, activation after storage over days, months or years
Sus scrofa
4C, activation after storage over days, months or years
Saccharomyces cerevisiae
4C, activation after storage over days, months or years
Bos taurus
4C, activation after storage over days, months or years
Oryctolagus cuniculus
4C, activation after storage over days, months or years
Penicillium chrysogenum
4C, activation after storage over days, months or years
Spinacia oleracea
4C, activation after storage over days, months or years
Meriones unguiculatus
4C, activation after storage over days, months or years
Allochromatium vinosum
4C, activation after storage over days, months or years
Scombridae
4C, activation after storage over days, months or years
Plasmodium vinckei
concentrated solution, years
Mus musculus
concentrated solution, years
Escherichia coli
concentrated solution, years
Homo sapiens
concentrated solution, years
Rattus norvegicus
concentrated solution, years
Sus scrofa
concentrated solution, years
Saccharomyces cerevisiae
concentrated solution, years
Bos taurus
concentrated solution, years
Oryctolagus cuniculus
concentrated solution, years
Penicillium chrysogenum
concentrated solution, years
Spinacia oleracea
concentrated solution, years
Meriones unguiculatus
concentrated solution, years
Allochromatium vinosum
concentrated solution, years
Scombridae
concentrated solution, years
Plasmodium vinckei
Substrates and Products (Substrate) (protein specific)
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
GSSG + NADPH
-
394708
Mus musculus
glutathione + NADP+
-
394708
Mus musculus
r
GSSG + NADPH
-
394708
Rattus norvegicus
glutathione + NADP+
-
-
-
?
GSSG + NADPH
-
394708
Sus scrofa
glutathione + NADP+
-
394708
Sus scrofa
?
GSSG + NADPH
-
394708
Sus scrofa
glutathione + NADP+
-
394708
Sus scrofa
r
GSSG + NADPH
-
394708
Bos taurus
glutathione + NADP+
-
394708
Bos taurus
?
GSSG + NADPH
-
394708
Bos taurus
glutathione + NADP+
-
394708
Bos taurus
ir
GSSG + NADPH
-
394708
Bos taurus
glutathione + NADP+
-
394708
Bos taurus
r
GSSG + NADPH
-
394708
Oryctolagus cuniculus
glutathione + NADP+
-
394708
Oryctolagus cuniculus
?
GSSG + NADPH
-
394708
Oryctolagus cuniculus
glutathione + NADP+
-
394708
Oryctolagus cuniculus
r
GSSG + NADPH
-
394708
Spinacia oleracea
glutathione + NADP+
-
394708
Spinacia oleracea
?
GSSG + NADPH
-
394708
Spinacia oleracea
glutathione + NADP+
-
394708
Spinacia oleracea
r
GSSG + NADPH
-
394708
Meriones unguiculatus
glutathione + NADP+
-
394708
Meriones unguiculatus
r
GSSG + NADPH
-
394708
Allochromatium vinosum
glutathione + NADP+
-
394708
Allochromatium vinosum
r
GSSG + NADPH
-
394708
Scombridae
glutathione + NADP+
-
394708
Scombridae
r
GSSG + NADPH
-
394708
Plasmodium vinckei
glutathione + NADP+
-
394708
Plasmodium vinckei
r
GSSG + NADPH
-
394708
Litomosoides carinii
glutathione + NADP+
-
394708
Litomosoides carinii
?
GSSG + NADPH
-
394708
Litomosoides carinii
glutathione + NADP+
-
394708
Litomosoides carinii
r
GSSG + NADPH
-
394708
Bufo bufo
glutathione + NADP+
-
394708
Bufo bufo
r
GSSG + NADPH
glutathione or other disulfides, e.g.: bis-L-gamma-glutamyl-L-cystinyl-bis-beta-alanine
394708
Escherichia coli
glutathione + NADP+
-
394708
Escherichia coli
?
GSSG + NADPH
glutathione or other disulfides, e.g.: bis-L-gamma-glutamyl-L-cystinyl-bis-beta-alanine
394708
Escherichia coli
glutathione + NADP+
-
394708
Escherichia coli
ir
GSSG + NADPH
glutathione or other disulfides, e.g.: bis-L-gamma-glutamyl-L-cystinyl-bis-beta-alanine
394708
Escherichia coli
glutathione + NADP+
-
394708
Escherichia coli
r
GSSG + NADPH
glutathione or other disulfides, e.g.: bis-L-gamma-glutamyl-L-cystinyl-bis-beta-alanine
394708
Rattus norvegicus
glutathione + NADP+
-
394708
Rattus norvegicus
?
GSSG + NADPH
glutathione or other disulfides, e.g.: bis-L-gamma-glutamyl-L-cystinyl-bis-beta-alanine
394708
Rattus norvegicus
glutathione + NADP+
-
394708
Rattus norvegicus
ir
GSSG + NADPH
glutathione or other disulfides, e.g.: bis-L-gamma-glutamyl-L-cystinyl-bis-beta-alanine
394708
Rattus norvegicus
glutathione + NADP+
-
394708
Rattus norvegicus
r
GSSG + NADPH
glutathione or other disulfides, e.g.: bis-L-gamma-glutamyl-L-cystinyl-bis-beta-alanine
394708
Saccharomyces cerevisiae
glutathione + NADP+
-
394708
Saccharomyces cerevisiae
?
GSSG + NADPH
glutathione or other disulfides, e.g.: bis-L-gamma-glutamyl-L-cystinyl-bis-beta-alanine
394708
Saccharomyces cerevisiae
glutathione + NADP+
-
394708
Saccharomyces cerevisiae
r
GSSG + NADPH
glutathione or other disulfides, e.g.: bis-L-gamma-glutamyl-L-cystinyl-bis-beta-alanine
394708
Penicillium chrysogenum
glutathione + NADP+
-
394708
Penicillium chrysogenum
?
GSSG + NADPH
glutathione or other disulfides, e.g.: bis-L-gamma-glutamyl-L-cystinyl-bis-beta-alanine
394708
Penicillium chrysogenum
glutathione + NADP+
-
394708
Penicillium chrysogenum
r
GSSG + NADPH
slight activity with D,L-lipoate
394708
Homo sapiens
glutathione + NADP+
-
394708
Homo sapiens
?
GSSG + NADPH
slight activity with D,L-lipoate
394708
Homo sapiens
glutathione + NADP+
-
394708
Homo sapiens
ir
GSSG + NADPH
slight activity with D,L-lipoate
394708
Homo sapiens
glutathione + NADP+
-
394708
Homo sapiens
r
GSSG + NADPH
mixed disulfide between coenzyme A and glutathione
394708
Homo sapiens
glutathione + NADP+
-
394708
Homo sapiens
?
GSSG + NADPH
mixed disulfide between coenzyme A and glutathione
394708
Homo sapiens
glutathione + NADP+
-
394708
Homo sapiens
ir
GSSG + NADPH
mixed disulfide between coenzyme A and glutathione
394708
Homo sapiens
glutathione + NADP+
-
394708
Homo sapiens
r
GSSG + NADPH
mixed disulfide between coenzyme A and glutathione
394708
Rattus norvegicus
glutathione + NADP+
-
394708
Rattus norvegicus
?
GSSG + NADPH
mixed disulfide between coenzyme A and glutathione
394708
Rattus norvegicus
glutathione + NADP+
-
394708
Rattus norvegicus
ir
GSSG + NADPH
mixed disulfide between coenzyme A and glutathione
394708
Rattus norvegicus
glutathione + NADP+
-
394708
Rattus norvegicus
r
GSSG + NADPH
mixed disulfide between coenzyme A and glutathione
394708
Saccharomyces cerevisiae
glutathione + NADP+
-
394708
Saccharomyces cerevisiae
?
GSSG + NADPH
mixed disulfide between coenzyme A and glutathione
394708
Saccharomyces cerevisiae
glutathione + NADP+
-
394708
Saccharomyces cerevisiae
r
GSSG + NADPH
slight activity with bis-N,N'-(gamma-glutamylcystine)
394708
Saccharomyces cerevisiae
glutathione + NADP+
-
394708
Saccharomyces cerevisiae
?
GSSG + NADPH
slight activity with bis-N,N'-(gamma-glutamylcystine)
394708
Saccharomyces cerevisiae
glutathione + NADP+
-
394708
Saccharomyces cerevisiae
r
GSSG + NADPH
glutathione-S-sulfonate
394708
Saccharomyces cerevisiae
glutathione + NADP+
-
394708
Saccharomyces cerevisiae
?
GSSG + NADPH
glutathione-S-sulfonate
394708
Saccharomyces cerevisiae
glutathione + NADP+
-
394708
Saccharomyces cerevisiae
r
GSSG + NADPH
maintenance of glutathione/GSSG ratio is a protective mechanism for intracellular thiols during growth in atmospheric oxygen
394708
Mus musculus
glutathione + NADP+
-
-
-
?
GSSG + NADPH
maintenance of glutathione/GSSG ratio is a protective mechanism for intracellular thiols during growth in atmospheric oxygen
394708
Escherichia coli
glutathione + NADP+
-
-
-
?
GSSG + NADPH
maintenance of glutathione/GSSG ratio is a protective mechanism for intracellular thiols during growth in atmospheric oxygen
394708
Homo sapiens
glutathione + NADP+
-
-
-
?
GSSG + NADPH
maintenance of glutathione/GSSG ratio is a protective mechanism for intracellular thiols during growth in atmospheric oxygen
394708
Sus scrofa
glutathione + NADP+
-
-
-
?
GSSG + NADPH
maintenance of glutathione/GSSG ratio is a protective mechanism for intracellular thiols during growth in atmospheric oxygen
394708
Saccharomyces cerevisiae
glutathione + NADP+
-
-
-
?
GSSG + NADPH
maintenance of glutathione/GSSG ratio is a protective mechanism for intracellular thiols during growth in atmospheric oxygen
394708
Bos taurus
glutathione + NADP+
-
-
-
?
GSSG + NADPH
maintenance of glutathione/GSSG ratio is a protective mechanism for intracellular thiols during growth in atmospheric oxygen
394708
Oryctolagus cuniculus
glutathione + NADP+
-
-
-
?
GSSG + NADPH
maintenance of glutathione/GSSG ratio is a protective mechanism for intracellular thiols during growth in atmospheric oxygen
394708
Penicillium chrysogenum
glutathione + NADP+
-
-
-
?
GSSG + NADPH
maintenance of glutathione/GSSG ratio is a protective mechanism for intracellular thiols during growth in atmospheric oxygen
394708
Spinacia oleracea
glutathione + NADP+
-
-
-
?
GSSG + NADPH
maintenance of glutathione/GSSG ratio is a protective mechanism for intracellular thiols during growth in atmospheric oxygen
394708
Meriones unguiculatus
glutathione + NADP+
-
-
-
?
GSSG + NADPH
maintenance of glutathione/GSSG ratio is a protective mechanism for intracellular thiols during growth in atmospheric oxygen
394708
Allochromatium vinosum
glutathione + NADP+
-
-
-
?
GSSG + NADPH
maintenance of glutathione/GSSG ratio is a protective mechanism for intracellular thiols during growth in atmospheric oxygen
394708
Scombridae
glutathione + NADP+
-
-
-
?
GSSG + NADPH
maintenance of glutathione/GSSG ratio is a protective mechanism for intracellular thiols during growth in atmospheric oxygen
394708
Plasmodium vinckei
glutathione + NADP+
-
-
-
?
GSSG + NADPH
high GSSG level in dormant stage
394708
Bufo bufo
glutathione + NADP+
-
-
-
?
additional information
-
394708
Mus musculus
?
-
-
-
-
additional information
-
394708
Rattus norvegicus
?
-
-
-
-
additional information
-
394708
Sus scrofa
?
-
-
-
-
additional information
-
394708
Saccharomyces cerevisiae
?
-
-
-
-
additional information
-
394708
Spinacia oleracea
?
-
-
-
-
additional information
-
394708
Meriones unguiculatus
?
-
-
-
-
additional information
-
394708
Allochromatium vinosum
?
-
-
-
-
additional information
glutathione redox cycle
394708
Homo sapiens
?
-
-
-
-
Subunits (protein specific)
Subunits
Commentary
Organism
dimer
-
Meriones unguiculatus
dimer
-
Mus musculus
dimer
-
Oryctolagus cuniculus
dimer
-
Spinacia oleracea
dimer
-
Sus scrofa
dimer
-
Rattus norvegicus
dimer
2 * 52500
Homo sapiens
dimer
-
Escherichia coli
dimer
-
Bos taurus
Turnover Number [1/s] (protein specific)
Turnover Number Minimum [1/s]
Turnover Number Maximum [1/s]
Substrate
Commentary
Organism
Structure
210
-
GSSG
-
Homo sapiens
Other publictions for EC 1.8.1.7
No.
1st author
Pub Med
title
organims
journal
volume
pages
year
Activating Compound
Application
Cloned(Commentary)
Crystallization (Commentary)
Engineering
General Stability
Inhibitors
KM Value [mM]
Localization
Metals/Ions
Molecular Weight [Da]
Natural Substrates/ Products (Substrates)
Organic Solvent Stability
Organism
Oxidation Stability
Posttranslational Modification
Purification (Commentary)
Reaction
Renatured (Commentary)
Source Tissue
Specific Activity [micromol/min/mg]
Storage Stability
Substrates and Products (Substrate)
Subunits
Temperature Optimum [C]
Temperature Range [C]
Temperature Stability [C]
Turnover Number [1/s]
pH Optimum
pH Range
pH Stability
Cofactor
Ki Value [mM]
pI Value
IC50 Value
Activating Compound (protein specific)
Application (protein specific)
Cloned(Commentary) (protein specific)
Cofactor (protein specific)
Crystallization (Commentary) (protein specific)
Engineering (protein specific)
General Stability (protein specific)
IC50 Value (protein specific)
Inhibitors (protein specific)
Ki Value [mM] (protein specific)
KM Value [mM] (protein specific)
Localization (protein specific)
Metals/Ions (protein specific)
Molecular Weight [Da] (protein specific)
Natural Substrates/ Products (Substrates) (protein specific)
Organic Solvent Stability (protein specific)
Oxidation Stability (protein specific)
Posttranslational Modification (protein specific)
Purification (Commentary) (protein specific)
Renatured (Commentary) (protein specific)
Source Tissue (protein specific)
Specific Activity [micromol/min/mg] (protein specific)
Storage Stability (protein specific)
Substrates and Products (Substrate) (protein specific)
Subunits (protein specific)
Temperature Optimum [C] (protein specific)
Temperature Range [C] (protein specific)
Temperature Stability [C] (protein specific)
Turnover Number [1/s] (protein specific)
pH Optimum (protein specific)
pH Range (protein specific)
pH Stability (protein specific)
pI Value (protein specific)
Expression
General Information
General Information (protein specific)
Expression (protein specific)
KCat/KM [mM/s]
KCat/KM [mM/s] (protein specific)
741997
Ku
Candida albicans glutathione ...
Candida albicans
Biochim. Biophys. Acta
1861
772-788
2017
-
-
-
-
-
-
-
-
-
-
-
-
-
3
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
1
1
-
-
-
742462
Plancarte
A new thioredoxin reductase w ...
Haemonchus contortus
Exp. Parasitol.
177
82-92
2017
-
-
-
-
-
-
2
1
-
1
1
-
-
2
-
-
1
-
-
-
1
-
1
1
-
-
1
1
-
-
-
1
-
-
1
-
-
-
1
-
-
-
1
2
-
1
-
1
1
-
-
-
-
1
-
-
1
-
1
1
-
-
1
1
-
-
-
-
-
-
-
-
1
1
742991
Dawson
Passive regeneration of gluta ...
Rana sylvatica
J. Exp. Biol.
220
3162-3171
2017
-
-
-
-
-
-
3
5
-
-
-
-
-
3
-
1
1
-
-
1
1
-
1
1
-
-
2
-
-
-
-
1
-
-
2
-
-
-
1
-
-
-
2
3
-
5
-
-
-
-
-
-
1
1
-
1
1
-
1
1
-
-
2
-
-
-
-
-
-
1
1
-
-
-
743417
Rodionova
Evaluation of new Cu(II) comp ...
Spinacia oleracea
Photosyn. Res.
133
139-153
2017
-
-
-
-
-
-
3
-
2
-
-
-
-
6
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
3
-
-
-
-
-
-
-
3
3
-
-
2
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
741875
Garnik
Glutathione reductase gene ex ...
Arabidopsis thaliana, Arabidopsis thaliana Columbia
Biochemistry (Moscow)
81
364-372
2016
-
-
-
-
-
-
-
-
5
-
-
-
-
11
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
5
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
2
-
-
2
-
-
741986
Ding
Glutathione reductase 2 maint ...
Arabidopsis thaliana
Biochim. Biophys. Acta
1857
665-677
2016
-
-
-
-
-
-
-
-
2
-
-
-
-
4
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
2
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
1
2
-
-
-
742814
Adem
Purification and Characteriza ...
Rattus norvegicus
J. Biochem. Mol. Toxicol.
30
295-301
2016
-
-
-
-
-
-
3
2
-
-
1
-
-
2
-
-
1
-
-
2
1
-
1
1
1
-
-
-
1
-
1
1
-
-
3
-
-
-
1
-
-
-
3
3
-
2
-
-
1
-
-
-
-
1
-
2
1
-
1
1
1
-
-
-
1
-
1
-
-
-
-
-
-
-
741644
Zhang
Functional validation of Phra ...
Phragmites australis
Appl. Biochem. Biotechnol.
175
3418-3430
2015
-
-
-
-
-
-
-
-
-
-
-
-
-
3
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
1
-
-
742468
Ji
Characterization of recombina ...
Colwellia psychrerythraea
Extremophiles
19
863-874
2015
-
-
1
-
-
-
-
2
-
-
1
-
-
7
-
-
1
-
-
-
-
-
1
1
-
-
4
2
-
-
-
2
-
-
-
-
-
1
2
-
-
-
-
-
-
2
-
-
1
-
-
-
-
1
-
-
-
-
1
1
-
-
4
2
-
-
-
-
-
1
1
-
2
2
743274
Achary
Glutathione reductase a uniqu ...
Cenchrus americanus
Mol. Biol. Rep.
42
947-962
2015
-
-
1
1
-
-
-
2
-
-
-
-
-
4
-
-
-
-
-
-
-
-
1
1
1
1
-
-
1
1
-
1
-
-
-
-
-
1
1
1
-
-
-
-
-
2
-
-
-
-
-
-
-
-
-
-
-
-
1
1
1
1
-
-
1
1
-
-
2
-
-
2
-
-
743530
Deng
Molecular cloning, expression ...
Hevea brasiliensis
Plant Physiol. Biochem.
96
53-63
2015
-
-
1
-
-
-
-
-
1
-
-
-
-
5
-
-
-
-
-
1
-
-
-
1
-
-
-
-
-
-
-
-
-
1
-
-
-
1
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
1
-
-
-
1
-
-
-
-
-
-
-
1
2
1
1
2
-
-
725618
Kedrowski
Glutathione reductase activity ...
Saccharomyces cerevisiae
J. Enzyme Inhib. Med. Chem.
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2014
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742059
Murakami
Copper-dependent inhibition a ...
Saccharomyces cerevisiae
Biometals
27
551-558
2014
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742448
Parrilha
Metal complexes with 2-acetyl ...
Rattus norvegicus
Eur. J. Med. Chem.
84
537-544
2014
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725067
Yan
Glutathione reductase is essen ...
Mus musculus
Free Radic. Biol. Med.
61C
320-332
2013
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2
2
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725617
Ekinci
Assesment of metal inhibition ...
Oncorhynchus mykiss
J. Enzyme Inhib. Med. Chem.
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11-15
2013
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725772
Arora
Purification and characterizat ...
Setaria cervi
J. Parasit. Dis.
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94-104
2013
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5
8
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1
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4
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1
1
1
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1
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1
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726094
Yadav
Identification of GR and TrxR ...
Setaria cervi
Parasitol. Int.
62
193-198
2013
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4
2
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1
1
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2
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2
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1
1
1
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1
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726192
Wu
Identification and characteriz ...
Oryza sativa
Plant Mol. Biol.
83
379-390
2013
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1
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2
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1
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7
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1
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3
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1
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2
1
1
2
-
-
726208
Gill
Glutathione and glutathione re ...
Acorus calamus, Arachis hypogaea, Beta vulgaris, Cajanus cajan, Citrullus lanatus, Citrus trifoliata, Cucumis melo, Cucumis sativus, Glycine max, Nicotiana tabacum, no activity in Drosophila melanogaster, no activity in Trypanosoma sp., Oryza sativa, Pisum sativum, Spinacia oleracea, Triticum aestivum, Vigna radiata var. radiata, Zea mays
Plant Physiol. Biochem.
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204-212
2013
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48
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16
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20
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16
16
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32
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32
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48
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16
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16
16
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16
16
-
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743172
Couto
Partition and turnover of glu ...
Saccharomyces cerevisiae, Saccharomyces cerevisiae BY4742
J. Proteome Res.
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2885-2894
2013
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1
1
1
1
-
-
743445
Yu
Plastid-localized glutathione ...
Arabidopsis thaliana
Plant Cell
25
4451-4468
2013
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1
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1
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4
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1
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1
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1
1
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-
743630
Lueersen
The glutathione reductase GSR ...
Caenorhabditis elegans
PLoS ONE
8
e60731
2013
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2
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1
1
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725616
Karaman
In vitro effects of some drugs ...
Homo sapiens
J. Enzyme Inhib. Med. Chem.
27
18-23
2012
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4
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1
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1
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2
2
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1
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1
4
-
4
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1
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4
4
4
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1
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1
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2
2
-
1
-
-
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-
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725689
Kim
Glutathione reductase from Ory ...
Oryza sativa
J. Microbiol. Biotechnol.
22
1557-1567
2012
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1
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1
1
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4
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1
1
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2
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1
2
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1
1
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1
1
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1
1
-
-
-
723817
Tandogan
In vitro effects of compounds ...
Bos taurus
Acta Biochim. Pol.
58
471-475
2011
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-
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3
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1
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3
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1
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3
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1
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2
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3
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2
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3
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1
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1
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3
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1
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700654
Rousar
Glutathione reductase is inhib ...
Rattus norvegicus, Saccharomyces cerevisiae
Physiol. Res.
59
225-232
2010
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-
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2
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5
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1
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2
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4
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4
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1
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2
-
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-
-
701093
Tandogan
Purification and kinetics of b ...
Bos taurus
Protein Pept. Lett.
17
667-674
2010
-
-
-
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2
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2
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3
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1
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1
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1
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2
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3
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1
-
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-
-
-
-
-
-
-
-
-
-
-
701146
Arias
Purification and characterizat ...
Phaeodactylum tricornutum
Protist
161
91-101
2010
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-
-
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-
6
2
-
-
5
-
-
3
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-
1
-
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1
2
-
2
1
1
-
1
-
1
1
1
1
4
1
4
-
-
-
1
-
-
-
4
6
4
2
-
-
5
-
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-
1
-
1
2
-
2
1
1
-
1
-
1
1
1
1
-
1
1
-
-
-
711008
Grellier
Antiplasmodial activity of qui ...
Homo sapiens, Plasmodium falciparum, Plasmodium falciparum FcB1
Arch. Biochem. Biophys.
494
32-39
2010
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-
-
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40
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3
-
5
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1
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25
-
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12
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4
35
-
8
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4
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8
40
35
-
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3
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1
-
-
25
-
-
-
-
12
-
-
-
-
-
-
-
-
15
15
711362
Li
Inhibition of both thioredoxin ...
Mus musculus
Biol. Trace Elem. Res.
136
294-301
2010
-
-
-
-
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1
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1
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3
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1
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2
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1
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1
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1
-
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-
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712604
Tandogan
Inhibition of purified bovine ...
Bos taurus
J. Enzyme Inhib. Med. Chem.
25
68-73
2010
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4
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2
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2
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1
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2
6
-
3
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2
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3
4
6
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2
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1
-
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713468
Can
Purification and characterisat ...
Rattus norvegicus
Protein J.
29
250-256
2010
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2
1
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1
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2
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1
-
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2
2
-
2
-
1
-
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-
1
-
-
3
-
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-
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-
-
3
-
-
-
-
-
-
2
1
-
1
-
-
-
-
1
-
2
2
-
2
-
1
-
-
-
1
-
-
-
-
1
1
-
2
2
724919
Al-Senaidy
-
Purification and characterizat ...
Camelus dromedarius
Eur. J. Sci. Res.
48
142-154
2010
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2
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2
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1
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1
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1
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1
1
1
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-
1
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-
1
-
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1
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2
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2
1
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1
-
1
-
-
1
1
1
-
-
-
1
-
-
-
-
-
-
-
-
-
726215
Mhamdi
Arabidopsis GLUTATHIONE REDUCT ...
Arabidopsis thaliana
Plant Physiol.
153
1144-1160
2010
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-
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-
-
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1
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2
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1
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1
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1
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1
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1
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-
1
-
-
1
-
-
-
-
-
-
-
-
-
-
1
1
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-
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726354
Tandogan
Comparative in vitro effects o ...
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40
405-411
2010
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2
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1
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1
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3
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-
1
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3
3
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1
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2
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
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726543
Garcia-Leiro
A functional analysis of Kluyv ...
Kluyveromyces lactis, Kluyveromyces lactis NRRL-Y1140
Yeast
27
431-441
2010
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1
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2
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5
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2
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1
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1
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1
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2
-
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-
-
2
-
-
-
-
-
-
-
-
-
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2
2
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696056
Park
Redox regulation of transcript ...
Mus musculus
Biochem. Biophys. Res. Commun.
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241-246
2009
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1
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-
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1
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1
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1
2
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-
1
-
-
-
-
-
-
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1
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696681
Sentuerk
In vitro inhibition of human e ...
Homo sapiens
Bioorg. Med. Chem. Lett.
19
3661-3663
2009
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12
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2
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1
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2
12
-
12
-
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2
-
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12
12
12
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-
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2
-
-
1
-
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-
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698440
Chen
Cloning, expression, and purif ...
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J. Agric. Food Chem.
57
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1
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1
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1
1
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-
1
2
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1
1
2
-
-
-
-
-
1
2
-
-
1
-
3
-
2
-
-
2
-
-
-
-
1
-
1
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1
1
-
-
1
2
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1
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2
2
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Senturk
Effects of some analgesic anae ...
Homo sapiens
J. Enzyme Inhib. Med. Chem.
24
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2009
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1
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2
2
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1
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-
-
-
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2
7
-
7
-
-
-
2
-
-
-
7
7
7
-
-
-
-
-
-
-
-
1
-
2
2
-
1
-
-
-
-
-
-
-
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-
-
699614
Sharma
Comparative modeling of thiore ...
Schistosoma mansoni
J. Mol. Graph. Model.
27
665-675
2009
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1
1
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699619
Iribarne
Assaying phenothiazine derivat ...
Homo sapiens
J. Mol. Graph. Model.
28
371-381
2009
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5
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5
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3
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1
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699801
Hong
Na+ but not Cl- or osmotic str ...
Oryza sativa
J. Plant Physiol.
166
1598-1606
2009
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-
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2
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2
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3
-
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1
-
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-
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1
-
-
1
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-
700776
Ding
Enhanced sensitivity to oxidat ...
Nicotiana tabacum
Plant Mol. Biol.
69
577-592
2009
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1
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2
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3
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1
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1
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1
-
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1
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-
700795
Kertulis-Tartar
Characterization of glutathion ...
Pteris ensiformis, Pteris vittata
Plant Physiol. Biochem.
47
960-965
2009
2
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2
4
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9
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7
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7
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2
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701018
Marty
The NADPH-dependent thioredoxi ...
Arabidopsis thaliana
Proc. Natl. Acad. Sci. USA
106
9109-9114
2009
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1
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2
4
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4
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1
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1
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1
1
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1
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1
1
-
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711000
Zhao
Effects of glutathione reducta ...
Chlorocebus aethiops
Arch. Biochem. Biophys.
485
56-62
2009
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-
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1
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1
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-
1
-
-
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-
-
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-
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1
1
-
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712066
Zhao
Increase in thiol oxidative st ...
Homo sapiens
Free Radic. Biol. Med.
47
176-183
2009
-
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1
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2
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4
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4
-
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1
-
-
-
-
-
-
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-
1
1
-
-
-
712997
Liu
Profiling patterns of glutathi ...
Saccharomyces cerevisiae
Mol. Biosyst.
5
1013-1024
2009
-
-
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5
-
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1
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1
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2
1
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3
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2
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3
5
1
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-
1
-
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-
-
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-
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-
-
-
-
686233
Tekman
Purification and characterizat ...
Oncorhynchus mykiss
Comp. Biochem. Physiol. C
148
117-121
2008
-
-
-
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-
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8
2
-
1
2
-
-
2
-
-
1
-
-
2
1
-
1
1
1
-
-
-
1
-
1
1
3
-
6
-
-
-
1
-
-
-
6
8
3
2
-
1
2
-
-
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-
1
-
2
1
-
1
1
1
-
-
-
1
-
1
-
-
-
-
-
-
-
686838
Koosz
Effects of decreased specific ...
Schizosaccharomyces pombe
Folia Microbiol. (Praha)
53
308-314
2008
-
-
-
-
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2
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-
687309
Scott
Harnessing the mechanism of gl ...
Escherichia coli
J. Am. Chem. Soc.
130
865-874
2008
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2
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1
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2
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-
-
1
-
-
-
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-
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-
-
-
-
-
-
688050
Bulbul
Investigation of the effects o ...
Homo sapiens
J. Enzyme Inhib. Med. Chem.
23
418-423
2008
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2
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2
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2
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2
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2
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2
2
2
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2
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-
-
-
-
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-
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-
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-
-
-
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-
688172
Prasad
Erythrocyte glutathione peroxi ...
Homo sapiens
J. Infect.
56
469-473
2008
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-
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3
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1
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1
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-
-
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-
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-
-
-
-
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-
-
-
688270
Friebolin
Antimalarial dual drugs based ...
Plasmodium falciparum
J. Med. Chem.
51
1260-1277
2008
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1
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5
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1
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-
-
-
-
-
-
-
-
-
-
-
-
-
689306
Morin
The aza-analogues of 1,4-napht ...
Homo sapiens, Plasmodium falciparum
Org. Biomol. Chem.
6
2731-2742
2008
-
-
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-
16
14
-
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3
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-
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-
1
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-
18
-
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-
14
-
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2
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-
12
-
-
-
2
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-
-
12
16
-
14
-
-
-
-
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-
-
-
-
1
-
-
18
-
-
-
-
14
-
-
-
-
-
-
-
-
-
-
689958
Angelucci
Glutathione reductase and thio ...
Schistosoma mansoni
Proteins
72
936-945
2008
-
-
1
1
-
-
-
4
-
-
1
-
-
2
-
-
1
-
-
-
-
-
2
1
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-
3
-
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2
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1
2
1
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4
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1
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1
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-
-
-
2
1
-
-
-
3
-
-
-
-
-
-
-
-
-
-
690134
Gunaratnam
Cr(VI) inhibits DNA, RNA and p ...
Homo sapiens
Toxicol. In Vitro
22
879-886
2008
-
-
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2
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2
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2
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-
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-
-
-
-
-
-
-
-
-
-
-
-
-
690147
Arning
Structure-activity relationshi ...
Homo sapiens
Toxicology
246
203-212
2008
-
-
-
-
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2
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2
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3
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1
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1
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2
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1
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2
2
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3
-
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1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
690217
Erat
Effect of polyamines on glutat ...
Spinacia oleracea
Z. Naturforsch. C
63
260-266
2008
-
-
-
-
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-
3
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2
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1
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3
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1
-
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-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
694642
Burritt
The polycyclic aromatic hydroc ...
Riccia fluitans
Plant Cell Environ.
31
1416-1431
2008
1
-
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-
-
-
-
-
-
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-
1
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1
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1
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1
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1
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-
1
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1
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-
1
-
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-
-
1
-
-
-
1
-
-
-
-
-
-
-
-
-
696556
Sentuerk
Dantrolene inhibits human eryt ...
Homo sapiens
Biol. Pharm. Bull.
31
2036-2039
2008
-
-
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-
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1
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2
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1
-
-
2
2
-
1
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-
2
1
-
1
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-
2
-
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-
1
1
1
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-
-
-
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-
1
-
2
2
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
697449
Cardoso
Reductive inactivation of yeas ...
Saccharomyces cerevisiae
Comp. Biochem. Physiol. A
151
313-321
2008
-
-
-
-
-
-
2
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-
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2
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1
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2
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2
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2
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-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
698010
Tarrio
The role of glutathione reduct ...
Kluyveromyces lactis, Kluyveromyces lactis NRRL-Y1140
FEMS Yeast Res.
8
597-606
2008
-
-
-
-
-
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1
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-
5
-
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-
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2
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2
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1
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-
-
-
-
-
-
-
-
-
-
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-
-
1
-
-
1
-
-
699224
Senturk
Effects of some antibiotics on ...
Homo sapiens
J. Enzyme Inhib. Med. Chem.
23
144-148
2008
4
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9
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1
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2
2
-
1
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-
-
-
-
-
-
2
9
-
9
4
-
-
2
-
-
-
9
9
9
-
-
-
-
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1
-
2
2
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
699884
Abd Ellah
Total glutathione and glutathi ...
Bos taurus
J. Vet. Med. Sci.
70
861-864
2008
-
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2
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4
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1
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1
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-
1
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-
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4
-
-
1
-
-
-
-
-
-
-
-
-
1
-
-
1
-
-
699961
Franco
Biochemical alterations in juv ...
Cyprinus carpio
Mar. Environ. Res.
66
88-89
2008
-
-
-
-
-
-
1
-
-
-
-
-
-
4
-
-
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-
-
4
-
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1
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-
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-
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-
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-
1
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-
1
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-
1
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1
1
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-
-
-
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-
-
4
-
-
1
-
-
-
-
-
-
-
-
-
1
-
-
1
-
-
700696
Hnken
Epiphytic bacteria on the Anta ...
Amphiprora kufferathii, Colwellia sp., Colwellia sp. MH2, Pibocella sp., Pibocella sp. MH3, Sulfitobacter sp., Sulfitobacter sp. MH1
Plant Biol.
10
519-526
2008
-
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5
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13
-
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5
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-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
673460
Erat
Effects of nicotine and vitami ...
Rattus norvegicus
Eur. J. Pharmacol.
554
92-97
2007
1
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2
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2
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1
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8
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1
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2
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1
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8
-
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-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
675954
Willmore
Purification and properties of ...
Trachemys scripta
Mol. Cell. Biochem.
297
139-149
2007
-
-
-
-
-
-
7
2
-
1
1
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-
8
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-
1
-
-
2
4
1
1
-
-
-
-
-
1
1
-
1
-
2
5
-
-
-
1
-
-
-
5
7
-
2
-
1
1
-
-
-
-
1
-
2
4
1
1
-
-
-
-
-
1
1
-
2
-
-
-
-
-
-
676388
Yannarelli
Glutathione reductase activity ...
Triticum aestivum
Phytochemistry
68
505-512
2007
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2
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-
685442
Hu
Glutathione- and thioredoxin-r ...
Homo sapiens
Biol. Chem.
388
1069-1081
2007
-
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4
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2
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4
4
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1
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1
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-
686077
Nagy
Kinetics and mechanism of the ...
Saccharomyces cerevisiae
Chem. Res. Toxicol.
20
79-87
2007
-
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2
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-
686259
Yan
Revival of glutathione reducta ...
Homo sapiens
Curr. Eye Res.
32
455-463
2007
-
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-
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2
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2
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-
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-
686856
Bishop
Zinc stimulates the production ...
Rattus norvegicus, Rattus norvegicus Wistar
Free Radic. Biol. Med.
42
1222-1230
2007
-
-
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-
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2
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167
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1
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1
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2
-
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-
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-
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-
688032
Tandogan
The inhibition kinetics of yea ...
Saccharomyces cerevisiae
J. Enzyme Inhib. Med. Chem.
22
489-495
2007
-
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4
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1
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1
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4
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1
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1
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-
-
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-
-
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-
688951
Ulusu
Purification and kinetic prope ...
Bos taurus
Mol. Cell. Biochem.
303
45-51
2007
-
-
-
-
-
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2
2
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1
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2
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1
1
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2
1
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1
1
1
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1
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1
4
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1
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2
4
2
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1
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1
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2
1
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1
1
1
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-
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1
-
-
-
-
-
-
-
-
-
689560
Bashir
Expression and enzyme activity ...
Hordeum vulgare, Oryza sativa, Triticum aestivum, Zea mays
Plant Mol. Biol.
65
277-284
2007
-
-
1
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4
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9
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2
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8
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8
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689967
Yu
Crystal structure of glutathio ...
Saccharomyces cerevisiae
Proteins Struct. Funct. Bioinform.
68
972-979
2007
-
-
1
1
1
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4
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6
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1
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1
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2
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1
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1
1
1
1
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4
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1
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1
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-
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-
2
-
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-
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-
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-
690144
Lalaouni
The interaction of chromium (V ...
Homo sapiens
Toxicology
236
76-81
2007
-
-
-
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1
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1
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2
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1
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1
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1
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1
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1
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-
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-
-
-
-
-
-
-
-
-
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-
671339
Contour-Ansel
Glutathione reductase in leave ...
Vigna unguiculata
Ann. Bot.
98
1279-1287
2006
1
-
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1
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2
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1
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1
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1
-
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-
-
-
-
-
-
-
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-
673031
Pivetta
Acetaldehyde does not inhibit ...
Mus musculus
Chem. Biol. Interact.
159
196-204
2006
-
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1
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-
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3
-
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2
1
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1
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1
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2
1
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
673458
Erat
Effect of melatonin on enzyme ...
Homo sapiens, Rattus norvegicus
Eur. J. Pharmacol.
537
59-63
2006
2
-
-
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2
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4
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2
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4
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2
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2
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2
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4
-
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2
-
-
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-
-
-
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-
-
-
-
-
-
-
-
673795
Sahoo
Effect of nitrosative stress o ...
Schizosaccharomyces pombe
Free Radic. Biol. Med.
40
625-631
2006
-
-
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1
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2
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2
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1
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2
-
-
-
-
-
-
-
-
-
-
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-
-
-
-
674175
Bauer
A fluoro analogue of the menad ...
Homo sapiens, Plasmodium falciparum
J. Am. Chem. Soc.
128
10784-10794
2006
-
-
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2
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10
-
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4
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-
-
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2
2
-
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-
-
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2
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10
-
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2
2
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-
10
10
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-
-
-
-
-
2
2
-
-
-
-
-
-
-
-
-
-
-
-
-
-
676198
Romero-Puertas
Glutathione reductase from pea ...
Pisum sativum
New Phytol.
170
43-52
2006
-
-
-
-
-
-
-
-
5
1
1
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4
-
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1
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1
1
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1
1
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1
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1
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1
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-
-
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5
1
1
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1
-
1
1
-
1
1
-
-
-
-
-
-
-
1
-
-
-
-
-
-
677215
Yang
Glutathione peroxidase and glu ...
Homo sapiens, Rattus norvegicus
Toxicology
226
126-130
2006
-
-
-
-
-
-
-
-
-
-
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5
-
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2
2
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2
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-
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2
2
-
2
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
656625
Tsai
Expression of ascorbate peroxi ...
Oryza sativa
J. Plant Physiol.
162
291-299
2005
3
-
1
-
-
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-
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1
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2
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3
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1
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1
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3
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1
1
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1
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3
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
657570
Erat
Purification of glutathione re ...
Gallus gallus
Appl. Biochem. Biotechnol.
125
127-138
2005
-
-
-
-
-
1
-
1
-
-
2
1
-
2
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1
-
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2
1
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2
1
1
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1
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1
1
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1
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-
1
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1
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2
1
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1
-
2
1
-
2
1
1
-
-
-
1
-
1
-
-
-
-
-
-
-
659484
Su
Mammalian selenoprotein thiore ...
Mus musculus, Rattus norvegicus
J. Biol. Chem.
280
26491-26498
2005
-
-
1
-
-
-
-
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1
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4
-
3
-
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1
-
8
-
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6
2
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-
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2
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1
2
-
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1
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4
-
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8
-
-
6
2
-
-
-
-
-
-
-
-
-
-
-
-
-
-
659592
Erat
Effects of some antibiotics on ...
Homo sapiens, Rattus norvegicus
J. Enzyme Inhib. Med. Chem.
20
69-74
2005
6
-
-
-
-
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4
-
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2
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4
-
-
1
-
-
4
1
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2
-
1
-
-
-
1
-
-
2
2
-
-
6
-
-
2
-
-
-
-
4
2
-
-
-
-
2
-
-
-
1
-
4
1
-
2
-
1
-
-
-
1
-
-
-
-
-
-
-
-
-
671698
Loprasert
The unique glutathione reducta ...
Xanthomonas campestris
Biochem. Biophys. Res. Commun.
331
1324-1330
2005
-
-
1
-
-
-
-
2
-
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1
-
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6
-
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1
-
-
-
2
-
3
1
-
-
-
2
-
-
-
-
-
-
-
-
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1
-
-
-
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-
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2
-
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1
-
-
-
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1
-
-
2
-
3
1
-
-
-
2
-
-
-
-
-
-
-
-
-
-
671910
Rice
Differential inhibition of cel ...
Homo sapiens, Mus musculus
Biochem. Pharmacol.
69
1463-1472
2005
-
-
-
-
-
-
4
-
-
-
-
-
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6
-
-
-
-
-
3
-
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2
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
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4
-
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-
-
-
-
-
-
3
-
-
2
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
673194
Rachdan
Glutathione reductase from hum ...
Homo sapiens
Curr. Eye Res.
30
919-925
2005
5
-
-
-
-
-
1
-
-
-
-
-
-
2
-
-
-
-
-
2
-
-
1
-
-
-
-
-
-
-
-
-
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5
-
-
-
-
-
-
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1
-
-
-
-
-
-
-
-
-
-
-
2
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
673790
Witte
Inhibition of thioredoxin redu ...
Saccharomyces cerevisiae
Free Radic. Biol. Med.
39
696-703
2005
-
-
-
-
-
-
4
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
4
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
674440
Deponte
Mechanistic studies on a novel ...
Homo sapiens
J. Biol. Chem.
280
20628-20637
2005
-
-
-
-
-
-
1
-
-
-
-
-
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2
-
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-
-
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1
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-
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-
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-
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-
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-
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1
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-
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-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
657763
Landino
Modulation of the redox state ...
Saccharomyces cerevisiae
Biochem. Biophys. Res. Commun.
314
555-560
2004
-
-
-
-
-
-
-
-
-
-
-
2
-
4
-
-
-
-
-
-
-
-
2
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
1
-
-
-
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-
-
-
-
-
-
2
-
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-
-
-
-
-
2
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
658250
Williams
Functional significance of the ...
Homo sapiens
Biol. Reprod.
71
1309-1316
2004
1
-
-
-
-
-
1
-
-
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1
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2
-
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-
-
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3
-
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2
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-
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1
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1
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1
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-
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1
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1
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-
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3
-
-
2
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
658730
Knapp
Cell-free production of active ...
Escherichia coli
FEBS Lett.
559
66-70
2004
-
-
1
-
1
-
-
-
-
-
-
1
-
2
-
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1
-
-
-
2
-
2
1
1
1
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-
1
-
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2
-
-
-
-
-
1
2
-
1
-
-
-
-
-
-
-
-
1
-
-
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1
-
-
2
-
2
1
1
1
-
-
1
-
-
-
-
-
-
-
-
-
659902
Rendon
Purification, characterization ...
Taenia crassiceps
Mol. Biochem. Parasitol.
133
61-69
2004
-
-
-
-
-
-
1
3
1
-
2
1
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3
-
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1
1
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2
1
-
1
1
1
-
-
-
1
-
-
2
-
1
-
-
-
-
2
-
-
-
-
1
-
3
1
-
2
1
-
-
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1
-
2
1
-
1
1
1
-
-
-
1
-
-
1
-
-
-
-
-
-
660485
Nagaoka
Glutathione reductase is expre ...
Rattus norvegicus
Redox Rep.
9
321-324
2004
-
-
-
-
-
-
1
-
-
-
-
1
-
1
-
-
-
-
-
3
-
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2
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659860
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Glutathione reductase from bov ...
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Optimized heterologous express ...
Anabaena sp.
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Probing the kinetic mechanism ...
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Evidence for the co-existence ...
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Modification of an essential a ...
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Glutathione reductase turned i ...
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Peroxynitrite modification of ...
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The purification and propertie ...
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Sugio
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Purification and some properti ...
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Occurrence of two isoforms of ...
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Purification and characterizat ...
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Effects of polyphenols, includ ...
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-
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1
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1
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15
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1
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1
-
-
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-
394738
Ermler
The three-dimensional structur ...
Escherichia coli
Proteins Struct. Funct. Genet.
9
174-179
1991
-
-
-
1
-
-
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1
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3
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1
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1
1
1
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1
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1
1
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1
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1
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1
1
1
-
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-
-
-
-
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-
-
-
663260
Henderson
Engineering the substrate spec ...
Escherichia coli, Homo sapiens
Proc. Natl. Acad. Sci. USA
88
8769-8773
1991
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-
-
-
5
-
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10
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5
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4
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6
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5
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10
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-
4
-
-
-
-
6
-
-
-
-
-
-
-
-
-
-
394716
Kidambi
Purification and thermal depen ...
Medicago sativa, Onobrychis viciifolia
Plant Physiol.
92
363-367
1990
-
-
-
-
-
-
-
2
-
-
6
-
-
4
-
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2
-
-
2
2
-
2
2
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2
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-
2
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2
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6
-
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2
-
2
2
-
2
2
-
-
-
-
-
-
-
-
-
-
-
-
-
-
394708
Schirmer
-
Glutathione reductase ...
Allochromatium vinosum, Bos taurus, Bufo bufo, Escherichia coli, Homo sapiens, Litomosoides carinii, Meriones unguiculatus, Mus musculus, Oryctolagus cuniculus, Penicillium chrysogenum, Plasmodium vinckei, Rattus norvegicus, Saccharomyces cerevisiae, Scombridae, Spinacia oleracea, Sus scrofa
Coenzymes and cofactors, Glutathione, Chem. Biochem. Med. Aspects Pt. A (Dolphin D, Poulson R, Avromonic O, eds. ) John Wiley & Sons, New York
3
553-596
1989
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-
-
2
-
42
75
8
4
-
1
16
-
16
-
-
1
5
-
13
6
28
65
9
-
-
-
1
-
-
-
49
23
-
-
-
-
-
49
2
-
42
-
75
23
8
4
-
1
16
-
-
-
1
-
13
6
28
65
9
-
-
-
1
-
-
-
-
-
-
-
-
-
-
394717
Acan
Sheep brain glutathione reduct ...
Ovis aries
FEBS Lett.
250
72-74
1989
-
-
-
-
-
-
-
-
-
-
2
-
-
2
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1
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2
1
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1
1
1
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2
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-
2
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2
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1
-
2
1
-
1
1
1
-
-
-
-
-
-
-
-
-
-
-
-
-
394775
Krauth-Siegel
NADPH-dependent disulphide red ...
Homo sapiens
Biochem. Soc. Trans.
17
315-317
1989
1
1
-
1
-
-
2
-
-
-
1
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1
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3
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1
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1
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1
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1
-
-
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-
-
-
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-
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394718
Wong
Glutathione reductase: solvent ...
Homo sapiens, Saccharomyces cerevisiae, Spinacia oleracea
Biochemistry
27
7091-7096
1988
-
-
-
-
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2
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6
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3
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3
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3
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3
3
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3
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3
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2
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3
-
3
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3
3
-
-
-
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-
-
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394719
Montero
-
Purification and characterizat ...
Phycomyces blakesleeanus
Biochim. Biophys. Acta
952
56-66
1988
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-
-
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-
1
2
2
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2
1
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1
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1
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1
1
1
2
1
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3
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2
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2
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2
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1
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2
-
2
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2
1
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1
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1
1
1
2
1
-
-
3
-
2
-
-
-
-
-
-
-
-
-
394715
Scrutton
Purification and characterizat ...
Escherichia coli
Biochem. J.
245
875-880
1987
-
-
1
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2
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2
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2
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1
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1
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1
1
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1
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1
1
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2
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2
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1
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1
-
1
1
-
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-
-
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394720
Shigeoka
Characterization and physiolog ...
Euglena gracilis, Euglena gracilis Z
Biochem. J.
242
511-515
1987
-
-
-
-
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11
1
1
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2
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24
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1
-
1
4
1
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-
2
-
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1
2
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2
-
-
-
-
11
-
1
1
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2
2
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-
1
-
1
4
1
-
-
2
-
-
-
1
-
-
-
-
-
-
-
394731
Connell
Pea chloroplast glutathione re ...
Pisum sativum
Plant Physiol.
82
351-356
1986
-
-
-
-
-
-
1
3
2
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2
1
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3
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1
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2
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3
1
1
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-
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1
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1
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1
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3
2
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2
1
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1
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2
-
3
1
1
-
-
-
-
-
-
-
-
-
-
-
-
-
394732
Bielawski
-
Properties of glutathione redu ...
Pisum sativum
Phytochemistry
25
2261-2265
1986
-
-
-
-
-
-
5
7
1
-
1
-
-
1
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1
-
-
2
1
-
1
1
-
-
3
-
2
2
-
2
-
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-
-
-
2
-
-
-
-
5
-
7
1
-
1
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1
-
2
1
-
1
1
-
-
3
-
2
2
-
-
-
-
-
-
-
-
394733
Rendon
Purification, properties, and ...
Arthrospira maxima
Arch. Biochem. Biophys.
248
215-223
1986
-
-
-
-
-
2
1
2
-
-
3
-
-
3
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1
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-
1
1
1
2
1
-
1
-
1
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-
3
-
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-
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-
3
-
-
2
-
1
-
2
-
-
3
-
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1
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-
1
1
1
2
1
-
1
-
1
-
-
-
-
-
-
-
-
-
394735
Zanetti
Properties of rabbit liver glu ...
Oryctolagus cuniculus
Arch. Biochem. Biophys.
244
831-837
1986
1
-
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3
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1
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2
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1
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2
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1
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2
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2
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
394711
Carlberg
Glutathione reductase ...
Bos taurus, Rattus norvegicus
Methods Enzymol.
113
484-490
1985
-
-
-
-
-
2
-
4
2
-
1
2
-
2
-
-
2
-
-
2
5
-
4
2
-
-
-
-
2
-
-
6
-
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-
-
-
6
-
-
2
-
-
-
4
2
-
1
2
-
-
-
2
-
2
5
-
4
2
-
-
-
-
2
-
-
-
-
-
-
-
-
-
394730
Krauth-Siegel
FAD analogues as prosthetic gr ...
Homo sapiens
Eur. J. Biochem.
148
335-344
1985
1
-
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1
-
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-
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-
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2
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1
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1
-
2
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2
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1
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2
1
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1
-
2
-
-
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-
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-
-
-
-
-
-
-
-
394736
Malaisse
The coupling of metabolic to s ...
Rattus norvegicus
Biochim. Biophys. Acta
844
256-264
1985
-
-
-
-
-
-
2
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1
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2
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2
1
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2
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1
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1
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2
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1
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2
1
-
2
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
438075
Carlberg
The effect of 2,4,6-trinitrobe ...
Homo sapiens
FEBS Lett.
180
102-106
1985
2
-
-
-
-
-
1
-
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1
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-
1
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1
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2
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1
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1
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
394737
Mata
Purification by affinity chrom ...
Escherichia coli, Escherichia coli S33
Z. Naturforsch. C
39
908-915
1984
-
-
-
-
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5
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4
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2
2
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3
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1
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-
1
1
6
1
1
-
1
-
2
1
2
2
-
-
-
-
-
-
2
-
-
5
-
-
-
4
-
-
2
2
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-
1
-
-
1
1
6
1
1
-
1
-
2
1
2
-
-
-
-
-
-
-
394741
Serrano
Purification and properties of ...
Anabaena sp., Anabaena sp. 7119
J. Bacteriol.
158
317-324
1984
-
-
-
-
-
-
3
2
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2
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10
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1
-
-
-
1
1
4
1
-
-
-
-
1
-
-
2
-
-
-
-
-
-
2
-
-
-
-
3
-
2
-
-
2
-
-
-
-
1
-
-
1
1
4
1
-
-
-
-
1
-
-
-
-
-
-
-
-
-
394740
Le Trang
Purification of glutathione re ...
Meriones unguiculatus
Anal. Biochem.
133
94-99
1983
-
-
-
-
-
-
1
-
-
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2
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1
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1
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-
1
-
-
2
1
1
-
-
-
-
1
-
2
-
-
-
-
-
-
2
-
-
-
-
1
-
-
-
-
2
-
-
-
-
1
-
1
-
-
2
1
1
-
-
-
-
1
-
-
-
-
-
-
-
-
394729
Untucht-Grau
Glutathione reductase from hum ...
Homo sapiens
Eur. J. Biochem.
120
407-419
1981
-
-
-
-
-
-
-
-
-
-
1
-
-
3
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1
1
-
2
-
-
1
1
-
-
-
-
-
-
-
2
-
-
-
-
-
-
2
-
-
-
-
-
-
-
-
-
1
-
-
-
-
1
-
2
-
-
1
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
394739
Carlberg
Purification and immunological ...
Rattus norvegicus
Biochim. Biophys. Acta
677
146-152
1981
-
-
-
-
-
-
-
-
1
-
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9
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1
-
-
2
1
-
1
-
1
-
-
-
-
-
-
1
-
-
-
-
-
-
1
-
-
-
-
-
-
-
1
-
-
-
-
-
-
1
-
2
1
-
1
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
394742
Carlberg
Purification and characterizat ...
Bos taurus
Anal. Biochem.
116
531-536
1981
-
-
-
-
-
-
-
2
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1
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1
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1
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-
1
1
1
1
1
-
-
-
-
1
-
-
2
-
-
-
-
-
-
2
-
-
-
-
-
-
2
-
-
1
-
-
-
-
1
-
1
1
1
1
1
-
-
-
-
1
-
-
-
-
-
-
-
-
-
394721
Boggaram
Purification of glutathione re ...
Sus scrofa
Anal. Biochem.
98
335-340
1979
-
-
-
1
-
-
-
2
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2
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2
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1
-
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2
1
-
1
1
-
-
-
-
2
-
-
3
-
-
-
-
-
-
3
1
-
-
-
-
-
2
-
-
2
-
-
-
-
1
-
2
1
-
1
1
-
-
-
-
2
-
-
-
-
-
-
-
-
-
394734
Zanetti
Rabbit liver glutathione reduc ...
Oryctolagus cuniculus
Arch. Biochem. Biophys.
198
241-246
1979
-
-
-
-
-
2
1
2
-
-
2
-
-
2
-
-
1
-
-
2
1
1
1
2
-
-
1
-
1
1
-
2
-
-
-
-
-
-
2
-
-
2
-
1
-
2
-
-
2
-
-
-
-
1
-
2
1
1
1
2
-
-
1
-
1
1
-
-
-
-
-
-
-
-
394743
Lopez-Barea
Mouse-liver glutathione reduct ...
Mus musculus
Eur. J. Biochem.
98
487-499
1979
-
-
-
-
-
7
4
2
-
-
2
-
-
6
-
-
1
-
-
2
1
1
2
1
-
-
3
-
-
-
-
1
-
-
-
-
-
-
1
-
-
7
-
4
-
2
-
-
2
-
-
-
-
1
-
2
1
1
2
1
-
-
3
-
-
-
-
-
-
-
-
-
-
-
394712
Moroff
Characterization of human plat ...
Homo sapiens
Biochim. Biophys. Acta
527
327-336
1978
5
-
-
-
-
-
6
1
1
5
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2
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1
-
-
2
-
-
1
-
1
-
-
-
1
-
-
3
6
-
-
5
-
-
3
-
-
-
-
6
6
1
1
5
-
-
-
-
-
1
-
2
-
-
1
-
1
-
-
-
1
-
-
-
-
-
-
-
-
-
394714
Schulz
-
The three-diemensional structu ...
Homo sapiens
Flavins and Flavoproteins (Proc. Int. Symp. , 6th, Meeting, Yagi, K. , Yamano, T. , eds. )
557-567
1978
-
-
-
1
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-
-
-
-
-
-
2
-
1
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-
1
-
1
-
-
3
1
-
-
-
-
-
-
-
2
-
-
-
-
-
-
2
1
-
-
-
-
-
-
-
-
-
2
-
-
-
-
-
1
-
-
3
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
394722
Boggaram
Characterization of glutathion ...
Sus scrofa
Biochim. Biophys. Acta
527
337-347
1978
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-
-
-
-
-
-
1
-
-
2
-
-
3
-
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1
-
-
2
-
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2
1
1
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-
-
2
-
-
3
-
-
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-
-
-
3
-
-
-
-
-
-
1
-
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2
-
-
-
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1
-
2
-
-
2
1
1
-
-
-
2
-
-
-
-
-
-
-
-
-
394744
Wirth
-
Partial purification and prope ...
Spinacia oleracea
Z. Pflanzenphysiol.
89
69-75
1978
-
-
-
-
-
1
-
1
-
-
1
-
-
1
-
-
1
-
-
1
1
-
2
-
-
-
-
-
1
1
-
3
-
-
-
-
-
-
3
-
-
1
-
-
-
1
-
-
1
-
-
-
-
1
-
1
1
-
2
-
-
-
-
-
1
1
-
-
-
-
-
-
-
-
394745
Halliwell
Properties and physiological f ...
Spinacia oleracea
Planta
139
9-17
1978
-
-
-
-
-
2
5
2
1
-
2
-
-
3
-
-
1
-
-
1
1
1
1
1
-
-
1
-
1
1
1
2
-
-
-
-
-
-
2
-
-
2
-
5
-
2
1
-
2
-
-
-
-
1
-
1
1
1
1
1
-
-
1
-
1
1
1
-
-
-
-
-
-
-
394746
Carlberg
Purification by affinity chrom ...
Saccharomyces cerevisiae
Biochim. Biophys. Acta
484
268-274
1977
-
-
-
-
-
-
-
-
-
-
-
-
-
2
-
-
1
-
-
-
1
-
1
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
1
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
394747
Pigiet
Purification of thioredoxin, t ...
Escherichia coli 11, Escherichia coli
J. Biol. Chem.
252
6367-6372
1977
-
-
-
-
-
-
-
-
-
-
2
-
-
3
-
-
1
-
-
-
1
-
2
1
-
-
-
-
-
-
-
2
-
-
-
-
-
-
2
-
-
-
-
-
-
-
-
-
2
-
-
-
-
1
-
-
1
-
2
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
393993
Williams
-
Flavin-containing dehydrogenas ...
Escherichia coli, Hemicentrotus pulcherrimus, Homo sapiens, Penicillium chrysogenum, Rattus norvegicus, Saccharomyces cerevisiae
The Enzymes, 3rd Ed. (Boyer, P. D. , ed. )
13
89-173
1976
-
-
-
-
-
-
10
6
1
-
-
10
-
6
-
-
-
-
-
-
-
-
27
-
4
-
-
1
4
-
-
12
-
-
-
-
-
-
12
-
-
-
-
10
-
6
1
-
-
10
-
-
-
-
-
-
-
-
27
-
4
-
-
1
4
-
-
-
-
-
-
-
-
-
394725
Worthington
Glutathione reductase from hum ...
Homo sapiens
Eur. J. Biochem.
67
231-238
1976
2
-
-
-
-
-
4
2
-
-
1
-
-
2
1
-
-
-
-
2
1
-
1
2
-
-
-
1
2
-
-
2
1
-
-
2
-
-
2
-
-
-
-
4
1
2
-
-
1
-
-
1
-
-
-
2
1
-
1
2
-
-
-
1
2
-
-
-
-
-
-
-
-
-
394727
Nakashima
Human erythrocyte glutathione ...
Homo sapiens
Biochim. Biophys. Acta
445
309-323
1976
-
-
-
1
-
-
4
3
-
-
-
-
-
2
-
-
1
-
-
2
2
-
2
-
-
-
-
-
2
-
-
3
5
-
-
-
-
-
3
1
-
-
-
4
5
3
-
-
-
-
-
-
-
1
-
2
2
-
2
-
-
-
-
-
2
-
-
-
-
-
-
-
-
-
394748
Tano
-
A NADPH:glutathione oxidoreduc ...
Acidithiobacillus thiooxidans
Agric. Biol. Chem.
40
1879-1880
1976
-
-
-
-
-
-
4
-
1
-
-
-
-
1
-
-
1
-
-
-
1
-
1
-
-
-
2
-
1
-
1
2
-
-
-
-
-
-
2
-
-
-
-
4
-
-
1
-
-
-
-
-
-
1
-
-
1
-
1
-
-
-
2
-
1
-
1
-
-
-
-
-
-
-
394749
Mannervik
Purification of glutathione re ...
Sus scrofa
FEBS Lett.
66
221-224
1976
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
1
-
-
1
1
-
1
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
1
-
-
-
-
-
-
-
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-
-
-
-
-
-
1
-
1
1
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
394726
Worthington
Glutathione reductase from hum ...
Homo sapiens
Eur. J. Biochem.
60
459-466
1975
-
-
-
-
-
-
-
-
-
-
3
-
-
2
-
-
-
-
-
2
-
-
1
2
-
-
-
-
-
-
-
2
-
-
-
-
-
-
2
-
-
-
-
-
-
-
-
-
3
-
-
-
-
-
-
2
-
-
1
2
-
-
-
-
-
-
-
-
-
-
-
-
-
-
394750
Carlberg
Purification and characterizat ...
Rattus norvegicus
J. Biol. Chem.
250
5475-5480
1975
-
-
-
-
-
-
1
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-
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2
-
-
3
-
-
1
-
-
2
1
-
2
1
-
-
-
-
2
-
-
3
-
-
-
-
-
-
3
-
-
-
-
1
-
-
-
-
2
-
-
-
-
1
-
2
1
-
2
1
-
-
-
-
2
-
-
-
-
-
-
-
-
-
394751
Chung
Purification and properties of ...
Allochromatium vinosum
J. Bacteriol.
123
203-211
1975
-
-
-
-
-
1
15
3
-
5
-
-
-
2
-
-
1
-
-
-
1
1
3
-
-
-
2
-
1
-
-
3
-
-
-
-
-
-
3
-
-
1
-
15
-
3
-
5
-
-
-
-
-
1
-
-
1
1
3
-
-
-
2
-
1
-
-
-
-
-
-
-
-
-
394724
Worthington
Human glutathione reductase: p ...
Homo sapiens
Eur. J. Biochem.
48
167-177
1974
-
-
-
1
-
-
-
-
-
-
-
-
-
2
-
-
1
-
-
2
1
1
1
1
-
-
-
-
-
-
-
2
-
-
-
-
-
-
2
1
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
2
1
1
1
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
394752
Ii
Glutathione reductase in the s ...
Hemicentrotus pulcherrimus
Biochim. Biophys. Acta
350
141-150
1974
-
-
-
-
-
-
1
3
-
1
2
-
-
1
-
-
1
1
-
1
1
1
1
1
1
-
-
-
1
-
-
4
-
-
-
-
-
-
4
-
-
-
-
1
-
3
-
1
2
-
-
-
-
1
-
1
1
1
1
1
1
-
-
-
1
-
-
-
-
-
-
-
-
-
394723
Harding
Affinity chromatography in the ...
Homo sapiens, Ovis aries, Saccharomyces cerevisiae, Triticum aestivum
J. Chromatogr.
77
191-199
1973
-
-
-
-
-
-
-
-
-
-
-
4
-
4
-
-
4
-
-
4
1
-
5
-
4
-
-
-
-
-
-
4
-
-
-
-
-
-
4
-
-
-
-
-
-
-
-
-
-
4
-
-
-
4
-
4
1
-
5
-
4
-
-
-
-
-
-
-
-
-
-
-
-
-
394709
Colman
-
Glutathione reductase (yeast) ...
Saccharomyces cerevisiae
Methods Enzymol.
17
500-503
1971
-
-
-
-
-
-
2
2
-
-
1
-
-
1
-
-
1
-
1
-
1
1
1
-
1
-
-
-
1
-
1
2
-
-
-
-
-
-
2
-
-
-
-
2
-
2
-
-
1
-
-
-
-
1
1
-
1
1
1
-
1
-
-
-
1
-
1
-
-
-
-
-
-
-
394710
Williams
-
Glutathione reductase (Escheri ...
Escherichia coli
Methods Enzymol.
17
503-509
1971
-
-
-
-
-
-
-
-
-
-
1
-
-
1
-
-
1
-
-
-
2
-
1
-
1
-
-
-
-
-
-
1
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
1
-
-
-
-
1
-
-
2
-
1
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
394728
Krohne-Ehrich
Glutathione reductase from hum ...
Homo sapiens
Eur. J. Biochem.
80
65-71
1971
-
-
-
1
-
-
-
-
-
-
-
1
-
2
-
-
1
-
-
2
1
-
2
-
-
-
-
-
-
-
-
2
-
-
-
-
-
-
2
1
-
-
-
-
-
-
-
-
-
1
-
-
-
1
-
2
1
-
2
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
394753
Ida
-
Studies on respiratory enzymes ...
Oryza sativa
Agric. Biol. Chem.
35
1542-1549
1971
-
-
-
-
-
-
-
-
-
-
1
-
-
1
-
-
1
-
-
1
1
-
1
-
-
-
-
-
-
-
-
3
-
-
-
-
-
-
3
-
-
-
-
-
-
-
-
-
1
-
-
-
-
1
-
1
1
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
394754
Ida
-
Studies on respiratory enzymes ...
Oryza sativa
Agric. Biol. Chem.
35
1550-1557
1971
-
-
-
-
-
-
-
2
-
-
2
-
-
1
-
-
-
-
-
1
-
-
1
1
-
-
-
-
1
1
-
2
-
-
-
-
-
-
2
-
-
-
-
-
-
2
-
-
2
-
-
-
-
-
-
1
-
-
1
1
-
-
-
-
1
1
-
-
-
-
-
-
-
-
394755
Boll
Glutathione reductase from Rho ...
Rhodospirillum rubrum
Arch. Mikrobiol.
66
374-388
1969
-
-
-
-
-
-
8
2
-
-
1
-
-
2
-
-
1
-
-
-
1
1
2
-
-
-
4
-
1
-
-
3
-
-
-
-
-
-
3
-
-
-
-
8
-
2
-
-
1
-
-
-
-
1
-
-
1
1
2
-
-
-
4
-
1
-
-
-
-
-
-
-
-
-
394713
Ruiz-Herrera
Purification and properties of ...
Achromobacter starkeyi
J. Biol. Chem.
243
4083-4088
1968
-
-
-
-
-
-
8
-
-
-
-
1
-
1
-
-
1
-
-
-
1
1
2
-
1
1
-
-
1
-
-
2
-
-
-
-
-
-
2
-
-
-
-
8
-
-
-
-
-
1
-
-
-
1
-
-
1
1
2
-
1
1
-
-
1
-
-
-
-
-
-
-
-
-