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Literature summary for 1.8.1.4 extracted from
- Dihydrolipoamide dehydrogenase moonlighting activity as a DNA chelating agent (2020), Proteins, 89, 21-28 .
Application
| Application | Comment | Organism |
|---|---|---|
| medicine | the enzyme is a DNA chelating agent. Enzyme binding to DNA presents a moonlight activity which may be used for DNA alkylating in cancer treatment | Homo sapiens |
Localization
| Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|
| mitochondrion | - |
Homo sapiens | 5739 | - |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Homo sapiens | P09622 | - |
- |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| dihydrolipoamide + NAD+ | - |
Homo sapiens | lipoamide + NADH + H+ | - |
? |  |
| dihydrolipoic acid + NAD+ | - |
Homo sapiens | lipoic acid + NADH + H+ | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| dihydrolipoamide dehydrogenase E3 | - |
Homo sapiens |
| DLDH | - |
Homo sapiens |
Cofactor
| Cofactor | Comment | Organism | Structure |
|---|---|---|---|
| FAD | - |
Homo sapiens | |
| NAD+ | - |
Homo sapiens | |
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Release 2023.1 (January 2023)
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