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Literature summary for 1.8.1.4 extracted from
- Chronic inhibition of mitochondrial dihydrolipoamide dehydrogenase (DLDH) as an approach to managing diabetic oxidative stress (2019), Antioxidants (Basel), 8, 32 .
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| 5-methoxyindole-2-carboxylic acid | - |
Homo sapiens |  |
Localization
| Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|
| mitochondrion | - |
Homo sapiens | 5739 | - |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Homo sapiens | P09622 | - |
- |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| dihydrolipoamide + NAD+ | - |
Homo sapiens | lipoamide + NADH + H+ | - |
? | |
Subunits
| Subunits | Comment | Organism |
|---|---|---|
| homodimer | - |
Homo sapiens |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| dihydrolipomide dehydrogenase | - |
Homo sapiens |
| DLDH | - |
Homo sapiens |
Cofactor
| Cofactor | Comment | Organism | Structure |
|---|---|---|---|
| FAD | contains FAD | Homo sapiens | |
| NAD+ | dependent on | Homo sapiens | |
General Information
| General Information | Comment | Organism |
|---|---|---|
| malfunction | chronic inhibition of the enzyme can attenuate oxidative stress in type 2 diabetes | Homo sapiens |
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