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Literature summary for 1.8.1.15 extracted from

  • Hayward, D.; Wiid, I.; van Helden, P.
    Differential expression of mycothiol pathway genes: are they affected by antituberculosis drugs? (2004), IUBMB Life, 56, 131-138.
    View publication on PubMed
Search for more literature for 1.8.1.15

Application

Application Comment Organism
medicine the enzyme is sensitive to free radical generating antituberculosis drugs and may be useful target for new drug development Mycobacterium tuberculosis variant bovis

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
mycothione + NADPH Mycobacterium tuberculosis variant bovis the enzyme is involved in mycothiol metabolism. Mycothiol may play an important role in the survival and adaption of mycobacteria to oxidative stress caused by normal metabolism, ir induced by the action of anti-tubercular drugs mycothiol + NADP+
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 ?

Organism

Organism UniProt Comment Textmining
Mycobacterium tuberculosis variant bovis
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-
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Source Tissue

Source Tissue Comment Organism Textmining
cell culture gene is actively transcribed during logarithmic growth Mycobacterium tuberculosis variant bovis
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Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
mycothione + NADPH the enzyme is involved in mycothiol metabolism. Mycothiol may play an important role in the survival and adaption of mycobacteria to oxidative stress caused by normal metabolism, ir induced by the action of anti-tubercular drugs Mycobacterium tuberculosis variant bovis mycothiol + NADP+
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 ?

Synonyms

Synonyms Comment Organism
NADPH-dependent mycothiol reductase
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 Mycobacterium tuberculosis variant bovis

Cofactor

Cofactor Comment Organism Structure
NADPH
-
 Mycobacterium tuberculosis variant bovis